Chronic renal failure in Iranian children

Madani, Kamyar; Otoukesh, Hassan; Rastegar, Asghar; Why, Scott Van

doi:10.1007/s004670000522

Cited by 61 publications

(44 citation statements)

References 13 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no evidence to suggest that the incidence of cystinosis is decreasing, indeed, as it is a common disease in communities with a high rate of consanguinity, one might expect it to be increasing [5]. Thus the fall in the numbers of ERF patients with cystinosis between cohorts is likely to be representative of improved diagnosis and treatment for the condition.…”

Section: Causes Of Erfmentioning

confidence: 91%

UK Renal Registry 11th Annual Report (December 2008): Chapter 13 Demography of the UK paediatric Renal Replacement Therapy population

et al. 2009

View full text Add to dashboard Cite

Aims: To describe the demographics of the paediatric RRT population in the UK and analyse changes in demographics with time. Methods: Extraction and analysis of data from the UK paediatric Renal Registry. Results: The UK paediatric established renal failure (ERF) population in April 2008 was 875 patients. The prevalence under the age of 16 years was 55 per million age related population (pmp) and the incidence 7.92 pmp. The incidence and prevalence for South Asian and Other ethnic groups were 3 times that of the White and Black populations. Renal dysplasia was the most common cause of ERF accounting for 33% of prevalent cases. Diseases with autosomal recessive inheritance were more common in patients from ethnic minority groups. The spectrum of diseases seen has changed over a generation. Overall 5 year survival for children with ERF was 91.8%. Five year survival of infants starting dialysis was just 62%. Transplanted patients accounted for 74% of the current population. The proportion with grafts from living donors has steadily risen to 34%. Children from ethnic minority groups were less likely to have an allograft and living donation was less frequent in this population. For those on dialysis, 57% were receiving peritoneal dialysis. This was the main treatment modality for patients under 4 years of age. Conclusions: The paediatric ERF population continued to expand slowly. Incidence and prevalence rates were stable and similar to other developed nations. The high incidence in patients from ethnic minority groups will lead to a greater proportion of the population being from these groups in time. To maintain the high proportion of engrafted patients it will be necessary to encourage living donation in the ethnic minority population. The spectrum of diseases seen has already changed over a generation with the treatment of young children with diseases such as congenital nephrosis. The incidence of cystinosis causing ERF was reduced, probably reflecting better early treatment.

show abstract

Section: Causes Of Erfmentioning

confidence: 91%

UK Renal Registry 11th Annual Report (December 2008): Chapter 13 Demography of the UK paediatric Renal Replacement Therapy population

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Although several studies of post-KTx UTI in adults have been published, results from adult studies cannot be easily extrapolated to children because, unlike adults, obstructive and reflux nephropathies are common causes of end stage kidney disease (ESKD) in children, and these conditions significantly increase the risk of UTI. In addition, the relative contribution of urological tract malformations to ESKD in children varies from centre to centre, as also does the rate of post-KTx UTI [1,3,7]. Consequently, the aim of our study was to determine the frequency of risk factors for UTI following KTx as well as its impact on graft function.…”

Section: Introductionmentioning

confidence: 99%

Urinary tract infection following kidney transplantation: frequency, risk factors and graft function

2011

View full text Add to dashboard Cite

The aim of this study was to determine the proportion of children who develop urinary tract infection (UTI) after kidney transplantation (KTx) and to identify the factors associated with UTI and its impact on graft function. To this end, we undertook a chart review of children who underwent KTx at Red Cross Children's Hospital between January 2003 and December 2009 and were followed-up for at least 6 months after transplantation. Sixty-two children (53.2% males) were followed-up for a mean (standard deviation) period of 36.9 (19.7) months. Mean age at transplantation was 10.0 (4.6) years. Twenty-five (40.3%) children had 89 UTI episodes during the study period, equivalent to 0.94 UTI episodes per one patient-year of follow-up. Acute pyelonephritis occurred in 17 (27.4%) children; another 17 (27.4%) had multiple post-KTx UTI. Klebsiella (40.0%) and Escherichia (28.0%) were the commonest organisms. Those with post-KTx UTI were, at transplantation, younger (8.3 vs. 11.2 years; p = 0.017), had lower urinary tract abnormality (LUTA) (13 vs. 1; p = 0.000) and had pre-KTx UTI (13 vs. 5; p = 0.001). Multivariate analysis revealed that only age <5 years at transplantation and LUTA remained significant and that UTI KTx was not associated with worsening graft function. UTI is common after post-KTx. Among our patient cohort, younger age and LUTA were risk factors, but UTI did not affect graft function.

show abstract

“…primary immunodeficiencies resulting in increased susceptibility to infectious disease(s) [51,52] , or chronic childhood kidney disorders [53,54] . However, in terms of absolute numbers, recessive disorders that are common and not restricted to any single community, such as non-syndromic hearing impairment [55,56] and intellectual and developmental disabilities [57,58] , should show the most obvious future decline in prevalence.…”

Section: Consanguinity Postnatal Mortality and The Prevalence Of Genmentioning

confidence: 99%

Consanguineous Marriage, Reproductive Behaviour and Postnatal Mortality in Contemporary Iran

Hosseini-Chavoshi

Abbasi-Shavazi²,

Bittles³

2014

Hum Hered

View full text Add to dashboard Cite

Objectives: The aims of the study were to determine the prevalence, types and socio-economic correlates of consanguineous marriages in Iran, and to gauge the extent to which consanguinity influenced fertility, pregnancy outcomes and the expression of genetic disorders in the present-day population. Methods: Data on the prevalence of consanguinity and birth outcomes in the first marriages of 5,515 women were abstracted from the 2005 Iran Low Fertility Study [Hosseini-Chavoshi et al: Fertility and Contraceptive Use Dynamics in Iran: Special Focus on Low Fertility Regions. Canberra, Australian National University, 2007]. The results of associated socio-economic variables were collated and assessed by Pearson's χ² analysis and logistic regression. Results: Overall, 37.4% of the marriages were consanguineous (α = 0.0149), but with major differences between 4 representative populations. Consanguinity was higher among rural couples, older marriage cohorts, women marrying at a younger age, and women with lower levels of formal education. In general, consanguineous couples had higher mean numbers of pregnancies, live births and surviving children. Conclusions: Given declining family sizes, a rapid urbanization and increased educational and employment opportunities, it seems inevitable that consanguineous marriages will decline in prevalence in Iran, albeit more slowly in more traditional rural communities. Predictably, there will be a concomitant reduction in the incidence of recessive genetic disorders, but this is against a background transition from communicable to non-communicable diseases.

show abstract

Chronic renal failure in Iranian children

Cited by 61 publications

References 13 publications

UK Renal Registry 11th Annual Report (December 2008): Chapter 13 Demography of the UK paediatric Renal Replacement Therapy population

UK Renal Registry 11th Annual Report (December 2008): Chapter 13 Demography of the UK paediatric Renal Replacement Therapy population

Urinary tract infection following kidney transplantation: frequency, risk factors and graft function

Consanguineous Marriage, Reproductive Behaviour and Postnatal Mortality in Contemporary Iran

Contact Info

Product

Resources

About