Chronic Renal Failure-Causes, Clinical Findings, Treatments and Prognosis

Olsen, E. G. J.; Galen, Gaby Van

doi:10.1016/j.cveq.2021.11.003

Cited by 25 publications

(20 citation statements)

References 84 publications

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“…e majority of individuals with stages I-III are asymptomatic or present moderate symptoms such as fatigue, anorexia, and mild anemia. Disease progression is associated with more severe symptoms such as heart failure, hyperkalemia, gastrointestinal bleeding, and neurological disorders, posing a great threat to the health of patients [4]. Evidence has con rmed the association of the occurrence of chronic renal failure with primary glomerular disease, diabetic nephropathy, immune disease kidney damage, and drug-related kidney damage; besides, the disease progression is accelerated in the presence of infection, insu cient blood circulation, and the use of nephrotoxic drugs [5].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Comprehensive Nursing in Hemodialysis of Patients with Chronic Renal Failure and the Impact on Their Quality of Life

Wen

Yao

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To assess the effectiveness of comprehensive nursing in patients with chronic renal failure undergoing hemodialysis and the impact on their quality of life. Methods. The present study included 86 patients undergoing hemodialysis for chronic renal failure from January 2020 to October 2021 and randomly assigned them to receive either normal nursing or comprehensive nursing, with 43 cases in each group. Outcome measures included psychological status, treatment compliance, quality of life, and complications of the eligible patients. Results. After the intervention, comprehensive nursing resulted in lower Self-Rating Anxiety Scale (SAS) scores and Self-Rating Depression Scale (SDS) scores and higher quality of life scores for patients versus routine nursing ( P < 0.05 ). Comprehensive nursing was associated with a significantly higher overall patient compliance rate versus routine nursing ( P < 0.05 ). Patients receiving comprehensive nursing had a lower risk of developing complications versus those given routine nursing ( P < 0.05 ). Conclusion. Comprehensive care increases treatment compliance and self-care capacity of patients undergoing hemodialysis for chronic renal failure, improves their quality of life, and lowers the risk of complications, indicating a high potential for clinical advancement.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of Comprehensive Nursing in Hemodialysis of Patients with Chronic Renal Failure and the Impact on Their Quality of Life

Wen

Yao

2022

Evidence-Based Complementary and Alternative Medicine

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“…Edema is known to be caused primarily due to cardiovascular (especially lymphatic) [ 20 ] and/or renal dysfunction. [ 21 ] Because VEGFR inhibition is known to influence vasculature, we visualized blood vessels using NBT/BCIP staining and lymphatic vessels using prox1 [ 22 ] antibody staining in cabozantinib‐exposed larvae. We found defects in blood and lymphatic vasculature, and a reduction in the expression of the lymphatic vessel marker genes prox1a and sox18 [ 23 ] due to cabozantinib.…”

Section: Discussionmentioning

confidence: 99%

Cabozantinib‐induced edema in zebrafish represents an adverse effect characterized by defects in lymphatic vasculature and renal function

Medishetti

Chatti

2023

J Biochem & Molecular Tox

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Tyrosine kinase inhibitors (TKIs) are a major class of targeted cancer therapy drugs. Overcoming the limitations of approved TKIs and the development of new TKIs continues to be an important need. The adoption of higher throughput and accessible animal models to evaluate TKI adverse effects will help in this regard. We exposed zebrafish larvae to a set of 22 Food and Drug Administration‐approved TKIs and assessed mortality, early developmental abnormalities, and gross morphological abnormalities posthatching. We found edema posthatching as a consistent and prominent consequence of VEGFR inhibitors, and of cabozantinib in particular. The edema occurred at concentrations that did not cause lethality or any other abnormality, and was independent of the developmental stage. Further experiments identified loss of blood and lymphatic vasculature, and suppression of renal function in larvae exposed to 10 µM cabozantinib. Molecular analysis showed downregulation of the vasculature marker genes vegfr, prox1a, sox18, and the renal function markers nephrin and podocin as the potential molecular basis for the above defects, implicating them in the mechanism of cabozantinib‐induced edema. Our findings reveal edema as a previously unreported phenotypic effect of cabozantinib and identify the likely mechanistic basis. These findings also highlight the need for studies investigating edema due to vascular and renal dysfunction as a potential clinical adverse effect of cabozantinib, and possibly other VEGFR inhibitors.

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“…The sample size calculation adopted a simple random sampling formula taking α = 0.05 and Z α /2 = 1.96. According to the study of the international incidence of CKD [9], it was estimated that the incidence of CKD was 12%, the error was taken by 5% and the required sample size was calculated to be 203 patients. Additionally, considering that there might be an invalid questionnaire, the required sample size was increased by 15%; thus, a total of 233 patients were selected.…”

Section: Methodsmentioning

confidence: 99%

Analysis of the association between glomerular filtration rate, proteinuria and metabolic syndrome in chronic kidney patients based on longitudinal data

Guo

Gong

et al. 2023

IET Nanobiotechnology

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Chronic kidney disease (CKD) is a group of chronic diseases caused by kidney damage from multiple causes. Metabolic syndrome (MS) manifests as dysfunction of endothelial cells and chronic functional inflammatory states, and may be involved in pathological changes related to renal impairment. Based on longitudinal data analysis of the association between estimated glomerular filtration rate (eGFR), proteinuria and MS in patients with CKD, this study aims to provide new ideas for the pathophysiological mechanism of CKD and a theoretical basis for the early prevention and effective intervention of MS‐related kidney damage. A total of 126 patients with CKD were divided into non‐MS group and MS group. According to the eGFR level, 126 patients with CKD were divided into G1 group, G2 group, G3a group, G3b group, G4 group and G5 group. Serum markers such as eGFR, urine protein, and triglycerides (TG) were collected. The correlation between eGFR, urine protein and MS‐related indexes was analysed, and the risk factors affecting CKD complicated by MS were analysed. In patients with CKD, the levels of urine protein, abdominal circumference, TG, systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FPG) were increased with the course of the disease, but the levels of eGFR and high density lipoprotein (HDL‐C) were decreased (p < 0.05). Abdominal circumference, TG, SBP, DBP, FP were significantly negatively correlated with eGFR, but HDL‐C was positively correlated with eGFR (p < 0.05). Diabetes, hyperlipidemia, UA, and SBP were independent risk factors affecting CKD complicated MS, and eGFR were independent protective factors (p < 0.05). The combination of diabetes, hyperlipidemia, UA, SBP, and eGFR exhibited higher prediction value for the CKD patients complicated by MS. There was a certain correlation between between MS components with eGFR and urinary protein in patients with CKD. The early intervention treatment of MS was helpful in delaying the development of CKD and reducing proteinuria.

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Chronic Renal Failure-Causes, Clinical Findings, Treatments and Prognosis

Cited by 25 publications

References 84 publications

Effectiveness of Comprehensive Nursing in Hemodialysis of Patients with Chronic Renal Failure and the Impact on Their Quality of Life

Effectiveness of Comprehensive Nursing in Hemodialysis of Patients with Chronic Renal Failure and the Impact on Their Quality of Life

Cabozantinib‐induced edema in zebrafish represents an adverse effect characterized by defects in lymphatic vasculature and renal function

Analysis of the association between glomerular filtration rate, proteinuria and metabolic syndrome in chronic kidney patients based on longitudinal data

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