Chronic renal dysfunction late after liver transplantation

De Novo Sirolimus and Reduced-Dose Tacrolimus Versus Standard-Dose Tacrolimus After Liver Transplantation: The 2000–2003 Phase II Prospective Randomized Trial

“…An important contributing factor to these improved clinical outcomes is the enhanced experience with calcineurin inhibitor (CNI)-based immunosuppressive therapy. However, CNIbased immunosuppression is associated with increased morbidity and important adverse effects including renal insufficiency, hypertension, diabetes, neurotoxicity and electrolyte abnormalities (2)(3)(4)(5). In this context, several hypotheses have been proposed to reduce CNI-related morbidity while avoiding higher risks of acute rejection, graft failure or patient death.…”

Treatment of renal dysfunction after orthotopic liver transplantation: Options and outcomes

“…A more recent publication found an incidence of CKD of 10% at 10 years. 3 In that series, 48% of patients were treated with cyclosporine, and 52%, with tacrolimus. There was no difference in degree of nephrotoxicity between the agents.…”

Renal Dysfunction and Liver Transplantation

“…In fact, liver transplant recipients have the highest five-yr incidence of CRF of any non-renal solid organ transplant recipient; additionally, the risk of death is at least fourfold higher in patients who develop CRF (Ojo et al, 2003). Numerous studies have been performed in the last decade in order to clarify the epidemiology and clinical significance of chronic kidney dysfunction among liver recipients (Fisher et al, 1998, Brown et al, 2001, Cohen et al, 2002& Herlenius et al, 2008.…”