Chronic renal dysfunction after liver transplantation in adult patients: prevalence, risk factors, and impact on mortality

Preserving renal function in liver transplant recipients with rabbit anti-thymocyte globulin and delayed initiation of calcineurin inhibitors

“…[2][3][4][5][7][8][9] Delaying the initiation of CNI with anti-thymocyte globulin in patients at high risk of acute renal failure was associated with a recovery in renal function in the early posttransplant period. Patients on this regimen also experienced a continual improvement in renal function, with a greater independence from dialysis, higher estimated GFR, and lower serum creatinine levels than control patients at 12 months posttransplant.…”

“…[1][2][3] Early renal dysfunction is a risk factor for chronic renal failure and is associated with significant morbidity and mortality in liver transplant recipients. 2,[4][5][6][7] Many risk factors such as preexisting renal impairment, hepatorenal syndrome, diabetes mellitus, liver allograft dysfunction, significant intraoperative blood loss, infection, and exposure to nephrotoxic calcineurin inhibitors (CNIs) have been reported to be associated with early renal dysfunction and acute renal failure after liver transplantation. 1,2,[8][9][10][11] Various strategies have been investigated to minimize the risk of acute renal failure after orthotopic liver transplantation, such as optimization of hemodynamic conditions in the operative and perioperative periods, but these strategies have not been successful.…”

Renal Dysfunction and Liver Transplantation

“…Even relatively mild elevations in pre-transplant creatinine >1.5 mg/dL may portend poor long term renal function. This was confirmed by many investigators (Moreno et al, 2003, Kim et al, 2004and Burra et al, 2009. A multivariate Cox regression analysis performed by Lee et al revealed that the overall risk of CKD development was associated with low pre transplant eGFR in addition to post-transplant acute renal failure (Lee et al, 2010).…”

Enfermedad renal crónica en pacientes trasplantados de hígado en el Hospital Pablo Tobón Uribe 2005-2013

“…La ERC es una complicación cada vez más frecuente en los pacientes que reciben un trasplante de hígado debido a la mayor expectativa de vida de estos pacientes (2). Aproximadamente 10% a 20% de los pacientes trasplantados de hígado presentan insuficiencia renal en los primeros cinco años luego del trasplante (3,4), pero puede ser hasta del 45% en el seguimiento a más largo plazo (5)(6)(7)(8)(9)(10)(11). Este amplio rango está dado por las diferentes definiciones que se le han dado en los estudios a la ERC así como a los méto-dos de medición de la creatinina, la técnica para calcular la depuración y condiciones particulares de los pacientes como la masa muscular.…”