Chronic Relapsing Pericarditis and Dilated Cardiomyopathy: Serological Evidence of Persistent Enterovirus Infection

Muir, Peter; Tilzey, AntheaJ.; English, T. A. H.; Nicholson, Felicity; Signy, Mark; Banatvala, J. E.

doi:10.1016/s0140-6736(89)92270-8

Cited by 114 publications

(40 citation statements)

References 14 publications

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“…Apart from iron loading itself, infectious myocarditis seems to play an important role in the pathogenesis of heart failure, possibly acting in a way similar to that observed in idiopathic dilated cardiomyopathy. Myocarditis may initiate an autoimmune reaction 31,32 in which HLA molecules seem to play a central role, through multiple pathogenetic mechanisms. Increased HLA antigen expression has been found in cardiac myocytes of patients with idiopathic dilated cardiomyopathy.…”

Section: Heart Failure In ␤-Thalassemia Majormentioning

confidence: 99%

Association of Heart Failure in Homozygous β-Thalassemia With the Major Histocompatibility Complex

et al. 1999

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Background —In β-thalassemia major, heart failure primarily affecting left ventricular systolic function is the most common complication and cause of death. Apart from iron deposition, it has been recently reported that myocarditis might be another contributing factor in the pathogenesis of acute or chronic heart failure, acting possibly through an autoimmune mechanism. In an attempt to assess the role of immunogenetic factors in the development of heart failure associated with β-thalassemia major, we studied the frequency of major histocompatibility antigens/alleles A, B, DR, and DQ in homozygous β-thalassemic patients with and without heart failure primarily affecting the left ventricle. Methods and Results —Forty-five consecutive unrelated Greek patients with homozygous β-thalassemia and left-sided chronic heart failure were studied. Fifty-eight unrelated Greek patients with homozygous β-thalassemia without heart failure and 130 unrelated Greek healthy controls were also studied. In all subjects, class I HLA-A and -B typing was performed by the complement-mediated lymphocytotoxicity assay, whereas class II HLA-DR and -DQ typing was performed by polymerase chain reaction. HLA-DRB1*1401 allele frequency was significantly increased in patients with β-thalassemia major without left-sided heart failure compared with those with heart failure (corrected P [ P c ]=0.02, odds ratio 0.1) and healthy controls ( P c =0.001). HLA-DQA1*0501 allele frequency was increased in patients with heart failure compared with patients without heart failure ( P c =0.04, odds ratio 14) and healthy controls ( P c =0.004). Conclusions —Differences exist in the immunogenetic profile between homozygous β-thalassemic patients with and without left-sided heart failure, raising the possibility that genetically defined immune mechanisms may play an important role in the pathogenesis of heart failure in β-thalassemia.

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Section: Heart Failure In ␤-Thalassemia Majormentioning

confidence: 99%

Association of Heart Failure in Homozygous β-Thalassemia With the Major Histocompatibility Complex

et al. 1999

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“…VI). With regard to therapeutics, non-steroidal anti-inflammatory drugs (NSAID) were prescribed to 5 …”

Section: Resultsmentioning

confidence: 99%

“…Acute idiopathic pericarditis, in general, is a self-limiting disease lasting 1 to 3 weeks with the potential for complications like myocarditis, cardiac tamponade, and late constrictive pericarditis 5 .…”

mentioning

confidence: 99%

Pericardite: série de 84 casos consecutivos

Zanettini¹,

Zanettini²,

Zanettini³

2004

Arq. Bras. Cardiol.

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“…Although this immunoglobulin is found more frequently in the DCM group than in nonselected controls 10 , no difference is seen when serologic data are compared with that obtained from relatives sharing the same domicile 12 . Sequential evaluation of serum specimens revealed antibodies persisting in some cases, as well as late seroconversion after reactions become negative in other cases 11,12 .…”

Section: Role Of Viral Infectionmentioning

confidence: 97%

“…The fact that most of the population has had contact with the virus, and the possibility of antibody levels remaining high after the acute phase of infection jeopardizes the evaluation of these results. Coxsackie B-specific immunoglobulin M is identified in patients with recent diagnosis and end-stage forms 10,11 . Although this immunoglobulin is found more frequently in the DCM group than in nonselected controls 10 , no difference is seen when serologic data are compared with that obtained from relatives sharing the same domicile 12 .…”

Section: Role Of Viral Infectionmentioning

confidence: 99%

Cellular and biomolecular mechanisms in dilated cardiomyopathy

Mattos¹

1999

Arq. Bras. Cardiol.

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Chronic Relapsing Pericarditis and Dilated Cardiomyopathy: Serological Evidence of Persistent Enterovirus Infection

Cited by 114 publications

References 14 publications

Association of Heart Failure in Homozygous β-Thalassemia With the Major Histocompatibility Complex

Association of Heart Failure in Homozygous β-Thalassemia With the Major Histocompatibility Complex

Pericardite: série de 84 casos consecutivos

Cellular and biomolecular mechanisms in dilated cardiomyopathy

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