Chronic Relapsing Experimental Allergic Encephalomyelitis

Grundke‐Iqbal, Inge; Lassmann, Hans; Wı́sniewski, Henryk M.

doi:10.1001/archneur.1980.00500590075013

Cited by 43 publications

(4 citation statements)

References 27 publications

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“…Demyelination may be induced either directly by complement-mediated cytolysis involving IgG2, by antibody-dependent cell-mediated cytolysis or by a process of opsonisation followed by phagocytosis. These latter possibilities are consistent with patho logical findings in CR-EAE [2,26] and with ultrastructural studies of macrophages within spinal cord lesions [27].…”

Section: Discussionsupporting

confidence: 88%

IgG Subclass Responses and Immediate Skin Sensitivity in Guinea-Pigs with Chronic Relapsing Experimental Allergic Encephalomyelitis

Walls¹,

Suckling²,

Rumsby³

1987

Int Arch Allergy Immunol

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In strain-13 guinea-pigs inoculated for chronic relapsing experimental allergic encephalomyelitis (CR-EAE), IgG1 and IgG2 subclass antibody responses were investigated using single radial immunodiffusion and enzyme-linked immunosorbent assays (ELISA) for IgG1 and IgG2 specific for whole cord, myelin, myelin basic protein and Mycobacterium tuberculosis. The early acute stage revealed no increase in IgG1 but was associated with increased levels of IgG2 specific for neural and adjuvant components. Throughout the chronic phase of the disease, there were increased levels of IgG of both subclasses specific for the antigens tested but a preferential synthesis of IgG1. Levels of both IgG1 and IgG2 specific for neuroantigens were lowest in those guinea-pigs which did not develop signs of chronic disease. Immediate skin sensitivity against a wide range of neural antigens was not demonstrated though positive results may have been masked by the ability of myelin basic protein to induce non-specific mast cell degranulation and by altered histamine responsiveness in disease. Guinea-pigs with chronic paralysis had a lower skin sensitivity to histamine, compound 48/80 and M. tuberculosis than those in remission.

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Section: Discussionsupporting

confidence: 88%

IgG Subclass Responses and Immediate Skin Sensitivity in Guinea-Pigs with Chronic Relapsing Experimental Allergic Encephalomyelitis

Walls¹,

Suckling²,

Rumsby³

1987

Int Arch Allergy Immunol

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“…Myelin breakdown is restricted to perivenular areas where cellular infiltration and increased vascular permeability are found (10,11). This is in accordance with the observation that during the first attack of chronic EAE, IgG can be eluted from the CNS, except in areas with cellular infiltrates (23). Oldstone & Dixon (1968) found precipitation of IgG in myelinated tracts in acute EAE (17).…”

Section: Discussionsupporting

confidence: 85%

The distribution of immunoglobulins and albumin in the central nervous system in acute experimental allergic encephalomyelitis

Juhler

Laursen

Barry

2009

Acta Neurologica Scandinavica

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Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Immunohistochemical visualisation of albumin and IgG in the nervous tissue was performed at intervals after induction. The results were correlated to the histological appearance of the tissue.Albumin appeared in the tissue about day 10, 1-2 days before IgG. Within one day both proteins spread from sharply defined perivascular subpial locations to diffuse distribution throughout the tissue. Cellular inflammation was not seen until 3-4 days after extravasation of proteins. The cells also spread from perivascular locations to a diffuse infiltration of the tissue.

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“…In experimental animals, complement deposition has been detected in the CP in mesangiocapillary glomerulonephritis in lambs ( 37 ), spontaneous immune complex disease in rats ( 38 ), experimental autoimmune encephalomyelitis (EAE) in guinea pigs ( 39 , 40 ), serum sickness in mice and rats ( 41 , 42 ), and experimental trypanosomiasis in mice ( 43 ).…”

Section: Introductionmentioning

confidence: 99%

“…In experimental animals, CP immunoglobulin has been demonstrated in normal hamsters ( 55 ), spontaneous lupus-like syndrome in nude mice ( 56 ), mesangiocapillary glomerulonephritis in lambs ( 37 ), spontaneous immune complex disease ( 38 ), subcutaneous inoculation of an antigen (horseradish peroxidase) ( 57 , 58 ), systemic injection of antibodies to proteins ( 58 , 59 ), acute and chronic serum sickness ( 42 , 60 , 61 ), EAE ( 39 , 40 ), experimental malaria ( 62 ), and experimental trypanosomiasis ( 43 ).…”

Section: Introductionmentioning

confidence: 99%

Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium

Moore¹,

Laule²,

Leung³

et al. 2016

J Neuropathol Exp Neurol

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The choroid plexus (CP) provides a barrier to entry of toxic molecules from the blood into the brain and transports vital molecules into the cerebrospinal fluid. While a great deal is known about CP physiology, relatively little is known about its immunology. Here, we show immunohistochemical data that help define the role of the CP in innate and adaptive humoral immunity. The results show that complement, in the form of C1q, C3d, C9, or C9neo, is preferentially deposited in stromal concretions. In contrast, immunoglobulin (Ig) G (IgG) and IgA are more often found in CP epithelial cells, and IgM is found in either locale. C4d, IgD, and IgE are rarely, if ever, seen in the CP. In multiple sclerosis CP, basement membrane C9 or stromal IgA patterns were common but were not specific for the disease. These findings indicate that the CP may orchestrate the clearance of complement, particularly by deposition in its concretions, IgA and IgG preferentially via its epithelium, and IgM by either mechanism.

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Chronic Relapsing Experimental Allergic Encephalomyelitis

Cited by 43 publications

References 27 publications

IgG Subclass Responses and Immediate Skin Sensitivity in Guinea-Pigs with Chronic Relapsing Experimental Allergic Encephalomyelitis

IgG Subclass Responses and Immediate Skin Sensitivity in Guinea-Pigs with Chronic Relapsing Experimental Allergic Encephalomyelitis

The distribution of immunoglobulins and albumin in the central nervous system in acute experimental allergic encephalomyelitis

Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium

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