Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice

Uchida, Shinichi; Umeeda, Hisahiro; Kitamoto, Aya; Masushige, Shoichi; Kida, Satoshi

doi:10.1016/j.brainres.2007.02.049

Cited by 26 publications

(12 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In experimental animals, reduction of serotonin neurotransmission by tryptophan depletion 13,14 or 5-HT 1A R agonist treatment 15 impair memory function. Stimulation of the 5-HT 1B R, a terminal autoreceptor, decreasing 5-HT release, causes memory deficits in rats and mice.…”

Section: Introductionmentioning

confidence: 99%

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11

et al. 2012

View full text Add to dashboard Cite

Cognitive impairments are common in depression and involve dysfunctional serotonin neurotransmission. The 5-HT1B receptor (5-HT1BR) regulates serotonin transmission, via presynaptic receptors, but can also affect transmitter release at heterosynaptic sites. This study aimed at investigating the roles of the 5-HT1BR, and its adapter protein p11, in emotional memory and object recognition memory processes by the use of p11 knockout (p11KO) mice, a genetic model for aspects of depression-related states. 5-HT1BR agonist treatment induced an impairing effect on emotional memory in wild type (WT) mice. In comparison, p11KO mice displayed reduced long-term emotional memory performance. Unexpectedly, 5-HT1BR agonist stimulation enhanced memory in p11KO mice, and this atypical switch was reversed after hippocampal adeno-associated virus mediated gene transfer of p11. Notably, 5-HT1BR stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice, as measured by both pre- and postsynaptic criteria. Magnetic resonance spectroscopy demonstrated global hippocampal reductions of inhibitory GABA, which may contribute to the memory enhancement and potentiation of pre- and post-synaptic measures of glutamate transmission by a 5-HT1BR agonist in p11KO mice. It is concluded that the level of hippocampal p11 determines the directionality of 5-HT1BR action on emotional memory processing and modulates hippocampal functionality. These results emphasize the importance of using relevant disease models when evaluating the role of serotonin neurotransmission in cognitive deficits related to psychiatric disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In our previous study, Pou3f2 Δ/Δ mice showed decreased brain levels of tryptophan hydroxylase and tyrosine hydroxylase (Nasu et al 2014). Accumulating evidence shows that serotonin and dopamine are closely related to mammalian cognitive function (Jay et al 2004;Jenkins et al 2010;Khaliq et al 2006;Levkovitz et al 2003;Porter et al 2003;Schmitt et al 2006;Tritsch & Sabatini 2012;Uchida et al 2007). Almost all serotonin and dopamine receptor subtypes are expressed in the hippocampus (Berumen et al 2012;Jay 2003;Khan et al 1998).…”

Section: Discussionmentioning

confidence: 93%

“…; Tritsch & Sabatini ; Uchida et al . ). Almost all serotonin and dopamine receptor subtypes are expressed in the hippocampus (Berumen et al .…”

Section: Discussionmentioning

confidence: 97%

POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian‐characteristic amino acid repeats

Hashizume

Yamanaka

Ueda

2017

Genes Brain and Behavior

View full text Add to dashboard Cite

POU3F2/BRN-2 is a transcription factor that is mainly expressed in the central nervous system and plays an important role in brain development. The transactivation domain of POU3F2 includes multiple mammalian-characteristic tandem amino acid repeats (homopolymeric amino acid repeats). We previously generated knock-in mice (Pou3f2 mice) in which all three homopolymeric amino acid repeats were deleted from the Pou3f2 transactivation domain and identified phenotypic impairments in maternal behavior and pup recognition. Yet, the exact biological implications of homopolymeric repeats are not completely understood. In this study, we investigated cognitive function and hippocampal neurogenesis in Pou3f2 mice. Pou3f2 mice exhibited cognitive impairment in object recognition and object location tests. Immunohistochemistry for doublecortin, a marker of immature neurons, showed a lower number of newborn neurons in the dentate gyrus of adult Pou3f2 mice compared with wild-type mice. Consistent with this observation, adult Pou3f2 mice had lower numbers of 5-bromo-2'-deoxyuridine (BrdU) and NeuN double-positive cells at 4 weeks after BrdU injection compared with control mice, indicating the decreased generation of mature granule cells in Pou3f2 mice. Taken together, these results suggest that POU3F2 is involved in cognitive function as well as adult hippocampal neurogenesis, and that homopolymeric amino acid repeats in this gene play a functional role.

show abstract

“…Thus, the same cortico‐limbic network may contribute to higher impulsivity after the ATD challenge and after aversive child hood experiences in MAOA ‐L carriers. Mouse models [see Uchida et al, ] may help to disentangle short‐ and long‐term effects of altered 5‐HT levels within specific neural circuits.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, the gene–environment interaction usually refers to an adverse environmental condition during development, and the current study employs the ATD challenge as an acute model. In a mouse model, chronic tryptophan depletion (1 month) induced lower anxiety and higher social dominance behavior [Uchida et al, ]. In a similar vein, increased impulsivity in humans may arise from reduced anxiety, and an increased stress response after reduced central 5‐HT during development.…”

Section: Limitationsmentioning

confidence: 99%

Cortico‐limbic connectivity in MAOA‐L carriers is vulnerable to acute tryptophan depletion

Eisner

Klasen

Wolf

et al. 2016

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice

Cited by 26 publications

References 72 publications

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11

POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian‐characteristic amino acid repeats

Cortico‐limbic connectivity in MAOA‐L carriers is vulnerable to acute tryptophan depletion

Contact Info

Product

Resources

About