Chronic Recurrent Multifocal Osteomyelitis:<i>A New Clinical-Radiological Syndrome</i>

Solheim, Ludvig Fjeld; Paus, Bernhard; Liverud, K; Stoen, E

doi:10.3109/17453678008990766

Cited by 59 publications

(12 citation statements)

References 7 publications

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“…Since its original description, there have been multiple case reports and studies of this disorder under a number of different names. These include subacute and chronic symmetric osteomyelitis, subacute symmetric osteomyelitis, chronic multifocal symmetric osteomyelitis, chronic multifocal cleidometaphyseal osteomyelitis of childhood, and chronic recurrent multifocal osteomyelitis (1,(3)(4)(5)(6). The term CRMO was first used by Probst and colleagues (3,5) and encompasses the typical clinical features of this entity: chronicity with a protracted course, involvement of more than one site, multiple exacerbations and relapses at old and new sites, and disease at sites that are typical of osteomyelitis in children.…”

Section: Introductionmentioning

confidence: 99%

Imaging of Chronic Recurrent Multifocal Osteomyelitis

Khanna¹,

Sato²,

Ferguson³

2009

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Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder of children and young adults that is characterized by nonbacterial osteomyelitis. Patients typically present with multifocal bone pain secondary to sterile osseous inflammation, and the disease has a relapsing and remitting course. The cause of CRMO remains unclear, although the results of several studies have suggested a genetic component. The typical imaging findings of CRMO include lytic and sclerotic lesions in the metaphyses of long bones and the medial clavicles. Other common sites of disease are the vertebral bodies, pelvis, ribs, and mandible. CRMO is often bilateral and multifocal at presentation. Owing to the lack of a diagnostic test, CRMO remains a diagnosis of exclusion. Although generally a self-limiting disease, CRMO can have a prolonged course and result in significant morbidity. Radiologists can be the first to suggest this diagnosis given its characteristic radiographic appearance and distribution of disease. Radiologists should be familiar with the typical imaging findings of CRMO to prevent unnecessary multiple biopsies and long-term antibiotic treatment in children with CRMO.

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Section: Introductionmentioning

confidence: 99%

Imaging of Chronic Recurrent Multifocal Osteomyelitis

Khanna¹,

Sato²,

Ferguson³

2009

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285

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“…Of further note, Giedion et al cite two other papers which detailed patients that probably had CMO and which preceded their article [7,8]. By the early 1980s, the entity of CMO was clearly gaining recognition [9][10][11]. Table 1 details many of the terminologies which were probably described as synonyms of CMO [4,6,12,13].…”

Section: Historical Aspectsmentioning

confidence: 93%

Chronic multifocal osteomyelitis: Is infectious causation a moot point?

Cimolai

2011

Journal of Infection and Public Health

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Chronic multifocal osteomyelitis (CMO) is an uncommon disease entity with descriptions possibly emanating from the medical literature over one century ago, and there are numerous disease entities which have been historically detailed and which are probably synonymous. The illness is one of chronicity with exacerbating and remitting focal bony lesions. The differential diagnosis for a bony lesion which ultimately proves to be CMO is initially quite broad. There is no absolute pathognomonic clinical finding, and the diagnosis is highly dependent on clinical course, histopathology, and an absence of microbial infection. Recent studies have focused on immune dysfunction or dysregulation, and there are now many other diseases which are inflammatory in nature and which have been diagnosed among patients with CMO. Despite the aforementioned, the potential for direct infectious causation or indirect causation by infectious stimulation of immunity cannot be entirely excluded. Infection as a mechanism for pathogenesis must continue to be entertained. Multi-centre studies are key to future research.

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“…Chronic recurrent multifocal osteomyelitis (CRMO) usually occurs in childhood and adolescence (Giedion et al 1972, Bjorksten et al 1978, Solheim et al 1980). It is considered to be an aseptic condition since cultures are nearly always negative.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions are often found in the metaphyses close to the epiphyseal cartilage, the clavicle being a favourite site for this disease. In a series of 101 lesions, 15 were located in the clavicle (Solheim et al 1980). …”

Section: Discussionmentioning

confidence: 99%