Chronic Recurrent Multifocal Osteomyelitis and Its Management

Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory disorder of bones first reported by Giedion et al. in 1972. It is a disease of childhood, comparable to SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) in adults. CRMO presents with pain and swelling overlying the involved bones. Inflammatory markers are usually raised and X-rays usually show sclerotic lesions. MRI demonstrates the extent of the lesions accurately and associated soft tissue changes. Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are the mainstays of the management. We report three patients who presented with bone pains. Extensive workup and radiological modalities along with clinical findings supported the diagnosis of CRMO. This article highlights important clinical presentations, radiological findings, and various management options.

A Successful Bisphosphonates Monotherapy in Spinal Form of Paediatric Chronic Recurrent Multifocal Osteomyelitis (CRMO)—Case Report

“…The frequency of bisphosphonate infusions was in accordance with previously described therapeutic attempts, though the quantity of cycles exceeded the previously reported mean [ 32 , 35 , 36 ]. Nevertheless other studies presented cases in which pamidronate was inefficient in controlling CRMO [ 17 , 37 , 38 ]. The aetiology of differences in response to bisphosphonates treatment is not yet clear.…”