Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder

Aygün, Deniz; Barut, Kenan; Camcioğlu, Yıldız; Kasapçopur, Özgür

doi:10.1136/bcr-2015-210061

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Microorganisms including atypical mycobacteria, anaerobic streptococci, coagulase-negative staphylococci, Propionibacterium acnes have been suggested as the cause, but the etiology of CRMO is yet unknown [10].…”

Section: Discussionmentioning

confidence: 99%

“…Instability between proinflammatory and anti-inflammatory cytokines [19], and also increased IL-1 β secretion by peripheral mononuclear cells of patients with CRMO during active disease [20], is known as an immune-pathogenic process. IL-1 blocking agents and TNF- α inhibitors can be used in treatment because IL-1 and TNF- α are essential in the pathogenesis of the disease [10].…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship?

Salehzadeh

Anari

Sarkhanloo

2019

Case Reports in Rheumatology

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Background and Objective. CRMO is an inflammatory disease of bone that occurs more often in children. The clinical manifestations are intermittent fever, pain, and bone lesions, especially in long bones. Although there is an idiopathic type of disease, it is usually associated with some autoimmune disorders. This study evaluates MEFV gene mutations as background pathology of idiopathic CRMO. Methods. Blood samples of patients, who diagnosed as childhood idiopathic CRMO by imaging and pathologic study from June 2011 until September 2018, have been screened for the 12 common pathogenic variants of MEFV gene mutations. Result. Nine patients enrolled in this study, and eight of them were male. The most common involvement locations were tibia and femur, and the least ones were zygoma, calcaneus, and radius. The mean duration of the involvement was 1.3 years. Six patients had only 1 involved location, 2 patients showed two sites of involvement, and one patient had three affected areas. There were two positive MEFV gene mutations (22%), as E148Q/wt and K695R/wt both in the heterozygote form. There was no meaningful relationship between MEFV gene mutations and the age of onset, gender, and location of involvement. Patients with positive mutation had more involved sites and long duration of involvement significantly. Conclusion. There is no significant immunopathogenic relationship between the common MEFV gene variant alleles and CRMO disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship?

Salehzadeh

Anari

Sarkhanloo

2019

Case Reports in Rheumatology

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“…Furthermore no pathogen was found. A clear notification for this phenomenon is [9]. Bone pains are usually the man symptoms; however this was difficult to report in our case of the premature neonate [10].…”

Section: Clinical Signs and Pathogenesismentioning

confidence: 71%

“…Increase of inflammatory markers can be seen in 66% of the case [11]. Though this phenomena is rare and mainly effects children in the age of 4-14 years [9].…”

Section: Clinical Signs and Pathogenesismentioning

confidence: 96%

Multifocal Osteomyelitis in a Neonate, an Overview of Diagnosis and Treatment

Mp¹,

Twente²

2015

ORP

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Osteomyelitis with arthritis in the neonatal period is a rare but severe condition. The incidence is approximately 0.5% of all neonatal admissions. Misdiagnosis is commonly due to unclear signs and symptoms. Delayed treatment can worsen outcome leading to permanent sequellae [1]. We present a unique case of multi-focal Septic Arthritis (SA) and acute Osteomyelitis (OM) due to a Staphylococcus aureus infection of unknown origin.

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“…En el periodo temprano de cicatrización se observa esclerosis en el mismo sitio o una mezcla de lesiones osteolíticas y escleróticas, pero, generalmente, en el transcurso de dos años, el hueso recupera su apariencia radiológica normal. Las radiografías también pueden ser normales en estadios tempranos de la enfermedad, por lo que se debe mantener un alto índice de sospecha [1][2][3][4][5]7,10,[29][30][31][32][33] .…”

Section: Estudios Con Imágenesunclassified

Osteomielitis crónica multifocal recurrente: estado del arte

Eusse

Velásquez-Franco

Navas

2016

MedUPB

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RESUMENLa osteomielitis crónica multifocal recurrente es una enfermedad autoinflamatoria que se caracteriza por focos estériles de inflamación ósea que producen dolor recurrente. Es una entidad poco frecuente que tiene como manifestaciones cardinales la presencia de lesiones óseas inflamatorias en las regiones metaepifisiarias de los huesos largos que predomina en miembros inferiores. Esta enfermedad, con frecuencia asociada con sínto-mas sistémicos y lesiones en piel, hace parte del grupo de enfermedades que conforma el síndrome: artritis-dermatitis. Los hallazgos radiológicos más comunes son las áreas de osteolisis rodeadas de un halo esclerótico delgado, sin reacción perióstica asociada o la formación de secuestros óseos. La resonancia nuclear magnética permite hacer una detección precoz de la entidad y facilita su diagnóstico diferencial, principalmente, con infecciones y tumores óseos. El tratamiento está basado en la información obtenida mediante reportes de caso y series de pacientes y consiste en el uso de antiinflamatorios no esteroideos y en casos refractarios, bisfosfonatos y antagonistas del factor de necrosis tumoral alfa. El pronóstico de esta enfermedad, en general, es bueno, con un curso clínico benigno y autolimitado, en la mayoría de los casos. Palabras clave: osteomielitis; inflamación; hiperostosis. ABSTRACTChronic recurrent multifocal osteomyelitis is a sterile autoinflammatory disease characterized by foci of sterile inflammation in the bone that generate recurrent pain. It is a rare entity in which the cardinal clinical manifestation is the presence of inflammatory bone lesions in metaepiphyseal regions of long bones, predominating in lower limbs. The disease is often associated with systemic symptoms and skin involvement making it part of the arthritis-dermatitis syndrome. The most common radiographic finding is osteolysis surrounded by a thin sclerotic halo, without periosteal reaction associated with bone formation or bone sequestrum. Magnetic resonance imaging allows early detection and facilitates the differential diagnosis between osteomyelitis and infections or bone tumors. Treatment is supported mainly by case reports and series of patients and consists of the use of nonsteroidal anti-inflammatory drugs and the use of bisphosphonates or tumor necrosis factor alpha antagonists in refractory cases. The prognosis of this disease is generally good, with a benign and self-limited clinical course in most cases.

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Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder

Cited by 8 publications

References 9 publications

Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship?

Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship?

Multifocal Osteomyelitis in a Neonate, an Overview of Diagnosis and Treatment

Osteomielitis crónica multifocal recurrente: estado del arte

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