Chronic recording of hand prosthesis control signals via a regenerative peripheral nerve interface in a rhesus macaque

Irwin, Zachary T.; Schroeder, Karen E.; Vu, Philip; Tat, D M; Bullard, Autumn J; Woo, Shoshana L.; Sando, Ian C.; Urbanchek, Melanie G.; Cederna, Paul S.; Chestek, Cynthia A.

doi:10.1088/1741-2560/13/4/046007

Cited by 56 publications

(58 citation statements)

References 34 publications

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“…Vibration-induced illusory kinesthesia (12) has been explored as a means of providing joint state information through activation of cutaneous stretch receptors; unfortunately, translation of this approach has been a major hurdle. Regenerative peripheral nerve interfaces have emerged as a means of stifling neuroma formation, preventing phantom pain, increasing the number of independent neural control targets, and conveying cutaneous sensory information (26,27). Targeted muscle reinnervation has a strong track record of improving controllability of myoelectric prostheses but is not designed to close the control loop with proprioceptive sensation (28,29).…”

Section: Introductionmentioning

confidence: 99%

Proprioception from a neurally controlled lower-extremity prosthesis

et al. 2018

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Humans can precisely sense the position, speed, and torque of their body parts. This sense is known as proprioception and is essential to human motor control. Although there have been many attempts to create humanmechatronic interactions, there is still no robust, repeatable methodology to reflect proprioceptive information from a synthetic device onto the nervous system. To address this shortcoming, we present an agonist-antagonist myoneural interface (AMI). The AMI is composed of (i) a surgical construct made up of two muscle-tendons-an agonist and an antagonist-surgically connected in series so that contraction of one muscle stretches the other and (ii) a bidirectional efferent-afferent neural control architecture. The AMI preserves the dynamic muscle relationships that exist within native anatomy, thereby allowing proprioceptive signals from mechanoreceptors within both muscles to be communicated to the central nervous system. We surgically constructed two AMIs within the residual limb of a subject with a transtibial amputation. Each AMI sends control signals to one joint of a two-degreeof-freedom ankle-foot prosthesis and provides proprioceptive information pertaining to the movement of that joint. The AMI subject displayed improved control over the prosthesis compared to a group of four subjects having traditional amputation. We also show natural reflexive behaviors during stair ambulation in the AMI subject that do not appear in the cohort of subjects with traditional amputation. In addition, we demonstrate a system for closed-loop joint torque control in AMI subjects. These results provide a framework for integrating bionic systems with human physiology.

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Section: Introductionmentioning

confidence: 99%

Proprioception from a neurally controlled lower-extremity prosthesis

et al. 2018

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“…The free muscle graft undergoes regeneration, revascularization, and reinnervation by the implanted peripheral nerve . An RPNI becomes a stable, peripheral nerve bioamplifier that is capable of producing high‐amplitude EMG signals . Previous work has shown that RPNIs can be successfully reinnervated and maintain a healthy electrical response for up to 7 months postimplantation in rats and 20+ months in nonhuman primates .…”

Section: Surgical Methods To Improve Peripheral Interfacesmentioning

confidence: 99%

“…An RPNI becomes a stable, peripheral nerve bioamplifier that is capable of producing high‐amplitude EMG signals . Previous work has shown that RPNIs can be successfully reinnervated and maintain a healthy electrical response for up to 7 months postimplantation in rats and 20+ months in nonhuman primates . In addition, RPNIs exhibited electrical properties equivalent to intact muscle, which can be utilized to control a prosthetic device …”

Section: Surgical Methods To Improve Peripheral Interfacesmentioning

confidence: 99%

The future of upper extremity rehabilitation robotics: research and practice

Chestek

Nason

et al. 2020

Muscle and Nerve

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The loss of upper limb motor function can have a devastating effect on people's lives.To restore upper limb control and functionality, researchers and clinicians have developed interfaces to interact directly with the human body's motor system. In this invited review, we aim to provide details on the peripheral nerve interfaces and brain-machine interfaces that have been developed in the past 30 years for upper extremity control, and we highlight the challenges that still remain to transition the technology into the clinical market. The findings show that peripheral nerve interfaces and brain-machine interfaces have many similar characteristics that enable them to be concurrently developed. Decoding neural information from both interfaces may lead to novel physiological models that may one day fully restore upper limb motor function for a growing patient population. K E Y W O R D S brain-machine interfaces, electrophysiology, neural decoding, neuroprosthetics, peripheral nerve interfaces, rehabilitation robotics

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“…Urbanchek et al [64] Regenerative Peripheral Nerve Interface (with cultured myoblasts) Irwin et al [66] Regenerative Peripheral Nerve Interfaces (with muscle tissue)…”

Section: Host Cell Electrodesmentioning

confidence: 99%

When Bio Meets Technology: Biohybrid Neural Interfaces

et al. 2019

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The development of electronics capable of interfacing with the nervous system is a rapidly advancing field with applications in basic science and clinical translation. Devices containing arrays of electrodes can be used in the study of cells grown in culture or can be implanted into damaged or dysfunctional tissue to restore normal function. While devices are typically designed and used exclusively for one of these two purposes, there have been increasing efforts in developing implantable electrode arrays capable of housing cultured cells, referred to as biohybrid implants. Once implanted, the cells within these implants integrate into the tissue, serving as a mediator of the electrode–tissue interface. This biological component offers unique advantages to these implant designs, providing better tissue integration and potentially long‐term stability. Herein, an overview of current research into biohybrid devices, as well as the historical background that led to their development are provided, based on the host anatomical location for which they are designed (CNS, PNS, or special senses). Finally, a summary of the key challenges of this technology and potential future research directions are presented.

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Chronic recording of hand prosthesis control signals via a regenerative peripheral nerve interface in a rhesus macaque

Abstract: The RPNI signal strength, stability, and longevity demonstrated here represents a promising method for controlling advanced prosthetic limbs and fully restoring natural movement.

Cited by 56 publications

References 34 publications

Proprioception from a neurally controlled lower-extremity prosthesis

Proprioception from a neurally controlled lower-extremity prosthesis

The future of upper extremity rehabilitation robotics: research and practice

When Bio Meets Technology: Biohybrid Neural Interfaces

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