Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex

Rousche, P.J.; Normann, Richard A.

doi:10.1016/s0165-0270(98)00031-4

Cited by 556 publications

(461 citation statements)

References 26 publications

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“…Progress is currently reaching a bottleneck, however, because traditional electronic materials, mostly metals and inorganic semiconductors, cannot satisfy the requirements of matching mechanical strength with biological systems 3,4 , high biocompatibility 5,6 , and stable electrical transduction [7][8][9][10][11] that are necessary for interfacial communication between materials and neural cells. Therefore, the focus has shifted recently towards the application of electrically conducting polymers (ECPs), which are conductors (or semiconductors) like metals, but with the ability to readily tailor their structures through covalent modification of their organic frameworks.…”

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confidence: 99%

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

et al. 2014

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Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it.

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confidence: 99%

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

et al. 2014

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“…Proof of concept for obtaining high-quality unit recordings for more than several months has been established through independent studies from several labs that collectively cover diverse types of microelectrode arrays implanted in rat, cat, and nonhuman primate (Rousche and Normann, 1998;Liu et al, 1999;Kipke et al, 2003;Nicolelis et al, 2003;McCreery et al, 2004;Suner et al, 2005;. However, there is a large degree of variability and unpredictability in chronic performance that results from an incomplete understanding of the failure (and success) modes of implantable microscale devices.…”

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confidence: 99%

Advanced Neurotechnologies for Chronic Neural Interfaces: New Horizons and Clinical Opportunities

Kipke¹,

Shain²,

Buzsáki³

et al. 2008

J. Neurosci.

258

176

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IntroductionTechnological advances in neural interfaces are providing increasingly more powerful "toolkits" of designs, materials, components, and integrated devices for establishing high-fidelity chronic neural interfaces. For a broad class of neuroscience studies, the primary requirements of these interfaces include recording and/or stimulating from a number of discretely sampled volumes at requisite spatial resolutions for specific periods of time. Translational and clinical applications present additional requirements for safety, usability, reliability, patient acceptance, and cost effectiveness. Innovative solutions result from the constructive tension between ever-increasing application requirements and incorporation of technological advances into usable devices. The purpose of this minireview is to present snapshots of the current state-of-the-art in chronic, microscale neural interfaces by highlighting several leading neuroscience applications and discussing their implications for next-generation interface devices.

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“…3). Of note, investigators at the University of Utah have developed two types of multi-array electrodes: the Utah electrode array (UEA) and the Utah slanted electrode array (USEA) [25,123]. Both are designed with the capacity to contain up to 100 microneedles which are implanted into neural tissue.…”

Section: Penetrating Multi-channel Arraysmentioning

confidence: 99%

Interfacing with the nervous system: a review of current bioelectric technologies

et al. 2017

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The aim of this study is to discuss the state of the art with regard to established or promising bioelectric therapies meant to alter or control neurologic function. We present recent reports on bioelectric technologies that interface with the nervous system at three potential sites-(1) the end organ, (2) the peripheral nervous system, and (3) the central nervous system-while exploring practical and clinical considerations.

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Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex

Cited by 556 publications

References 26 publications

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

Advanced Neurotechnologies for Chronic Neural Interfaces: New Horizons and Clinical Opportunities

Interfacing with the nervous system: a review of current bioelectric technologies

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