Chronic Pruritus: Clinics and Treatment

Grundmann, Sonja; Ständer, Sonja

doi:10.5021/ad.2011.23.1.1

Cited by 82 publications

(91 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The identification of pruritus-specific C-fibers (pruriceptors) has confirmed the existence of a specific pathway for CP [5]. Polymodal Cfibers are the most commonly involved fibers in CP, but are insensitive to histamine.…”

Section: Introductionmentioning

confidence: 74%

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

Wang

Liu²,

Yin³

et al. 2013

Pharmacology

View full text Add to dashboard Cite

Objectives: To assess whether olopatadine hydrochloride (OH) was noninferior to cetirizine in the treatment of cutaneous pruritus (CP). Patients and Methods: Patients with CP presenting at seven centers in China were randomly allocated to double-blind treatment with 5 mg of OH orally twice a day or cetirizine 10 mg orally once a day for 2 weeks. Patients were followed up on days 7 and 14. Noninferiority was predefined as a 20% maximum difference in the reduction of symptom score reducing indices (SSRI). Both intention-to-treat (ITT) and per-protocol populations were analyzed. Results: 174 patients (86 receiving OH and 88 cetirizine) were included in the ITT population. In the ITT population, the mean reduction in SSRI was 0.640 ± 0.274 in the OH group and 0.603 ± 0.289 in the cetirizine group. The one-sided 97.5% CI (–0.047) met the criteria for noninferiority. Noninferiority was also demonstrated for SSRI in the per-protocol population, with reductions of 0.640 ± 0.271 with OH and 0.596 ± 0.287 with cetirizine (97.5% CI –0.043).The total effectiveness rate (TER) was similar in the OH (90.0%) and cetirizine (80.0%) groups. The corresponding one-sided 97.5% CI (–1.0%) also demonstrated noninferiority. The incidence of adverse events was 47.1% in the OH group and 41.4% in the cetirizine group (p = 0.453). Conclusion: The efficacy of OH was noninferior to that of cetirizine in controlling itching indicating that it can be considered as a clinically relevant alternative therapy to cetirizine for the management of CP in adult Chinese patients.

show abstract

Section: Introductionmentioning

confidence: 74%

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

Wang

Liu²,

Yin³

et al. 2013

Pharmacology

View full text Add to dashboard Cite

show abstract

“…Considering chronicity, duration of pruritus is a criterion for its classification. In this manner a 6 week duration is the boundary between an acute and a chronic itch (6).…”

Section: Introductionmentioning

confidence: 99%

Role of Pregabalin in Management of Pruritus: A Literature Review

Foroutan

Nikvarz

2016

J Pharm Pharm Sci

View full text Add to dashboard Cite

-Purpose. Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Itch sensation is transferred to the central nervous system via unmyelinated C-type nerve fibers, and many mediators and receptors engage in the its induction and transmission. Also it has been demonstrated that there are similarities and interactions between neurotransmitters and pathways of pain and itch sensation. Hence, effective drugs in reducing the neuropathic pain such as pregabalin have been studied and used in the management of different itchy conditions. In this narrative review we considered the available published papers dealing with the antipruritic effects of pregabalin. Results of studies conducted in uremic patients show that pregabalin is an effective option in reducing uremic pruritus especially in those who have not responded to antihistamines and topical moisturizers. Data about the effects of pregabalin on other itchy conditions are very limited; however results of the available studies show beneficial effects of this drug in burn patients with more than 5% involvement of the total body surface area, in prurigo nodularis, and in chronic and idiopathic itch. One considerable issue is that the therapeutic effects of pregabalin on uremic pruritus and post burn itch may appear more rapidly than its effects in the other conditions (1-2 weeks vs > 4 weeks). The most reported adverse effects of pregabalin are sedation, dizziness and drowsiness. Whether pregablin can be unequivocally considered as an effective and reasonable choice in the management of pruritus with different causes is a question that should be answered through large scale randomized controlled studies.

show abstract

“…5 Histamine released from mast cells has been thought to be the predominant mediator of pruritus. 6,7 However, many patients with pruritus do not respond to anti-histamines. Various other disease-specific neuromediators (like neuropeptides, proteases, opioids, kinins and cytokines) that act peripherally and centrally have been identified.…”

Section: Pathophysiology Of Pruritusmentioning

confidence: 99%

“…7,12 Certain systemic treatments may be more effective than others depending on the cause of the pruritus. The systemic treatments (besides anti-histamines) used to treat pruritus are summarized in Table 10.…”

Section: Systemic Treatmentsmentioning

confidence: 99%

Pruritus in older people

2013

Rev. Clin. Gerontol.

View full text Add to dashboard Cite

Pruritus in older people is caused by a wide range of dermatological, systemic, neurological and psychogenic diseases. It can also be attributed to various cutaneous drug reactions. The dermatological, neurological and immunological changes associated with ageing predispose older people to pruritus of a wide range of aetiologies. The most common cause of pruritus in older people is xerosis, or dry skin. Regular use of emollients is the mainstay of treatment for pruritus of any cause, with general measures aiming to ensure optimal skin hydration and to prevent the itch-scratch cycle. Topical treatments are generally better tolerated for localized pruritus. Anti-histamines are the predominant agents to treat pruritus, but can be inadequate in many cases. Numerous other systemic agents have been demonstrated to alleviate pruritus depending on the cause, but may be limited by their adverse effects. This article reviews the current published literature on pruritus in older people, with a practical approach to its evaluation and management in non-specialist settings.

show abstract

Chronic Pruritus: Clinics and Treatment

Cited by 82 publications

References 52 publications

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

Role of Pregabalin in Management of Pruritus: A Literature Review

Pruritus in older people

Contact Info

Product

Resources

About

Chronic Pruritus: Clinics and Treatment

Cited by 82 publications

References 52 publications

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

Role of Pregabalin in Management of Pruritus: A Literature Review

Pruritus in older people

Contact Info

Product

Resources

About

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus

A Multicenter, Double-Blind, Randomized, Noninferiority Comparison of 14 Days Treatment with Oral Olopatadine 10 mg or Cetirizine 10 mg in Chinese Adults with Cutaneous Pruritus