1970
DOI: 10.1016/0022-510x(70)90001-8
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Chronic proximal spinal muscular atrophy

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Cited by 69 publications
(20 citation statements)
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“…It is inherited as an autosomal recessive disorder although sporadic cases do occur [7]. Despite continued interest in the developed countries, there is little information on SMA in the Arabian peninsula and developing communities [8][9][10][11][12][13][14][15][16]. This communication reports the results of a clinical study of SMA type I conducted in a teaching hospital in the Eastern Province of Saudi Arabia.…”
mentioning
confidence: 99%
“…It is inherited as an autosomal recessive disorder although sporadic cases do occur [7]. Despite continued interest in the developed countries, there is little information on SMA in the Arabian peninsula and developing communities [8][9][10][11][12][13][14][15][16]. This communication reports the results of a clinical study of SMA type I conducted in a teaching hospital in the Eastern Province of Saudi Arabia.…”
mentioning
confidence: 99%
“…We suggested that a similar inhibitory effect in vivo on the binding of specific antibodies to AcChoR at the neuromuscular junction may occur during pregnancy in patients with myasthenia gravis. Because myasthenia gravis is an autoimmune disease caused by the immunopathologic effect of specific autoantibodies directed against AcChoR at the neuromuscular junction (3), such inhibitory effects may help to explain two phenomena observed in myasthenia gravis during pregnancy and after delivery: The occurrence of partial or complete remissions during the second and (especially) the third trimester, as well as exacerbations during the early postpartum period (4)(5)(6)(7)(8); and the appearance of transitory neonatal myasthenia gravis (NMG) in the newborn babies, due to placental transfer of maternal antibodies (9)(10)(11), only after birth and only in a minority of the cases (12,13). This paper presents experimental data showing that the immunosuppressant a-fetoprotein, but not other components derived from both human amniotic fluid and human umbilical cord, is the factor inhibiting the binding of antibodies to AcChoR antigen present in these fluids.…”
mentioning
confidence: 99%
“…The disease was more severe in female sibs than in male sibs, in contrast to the usual pattern (Namba, Aberfeld, and Grob, 1970).…”
Section: Discussionmentioning
confidence: 60%