Chronic prostatitis: A thorough search for etiologically involved microorganisms in 1,461 patients

Weidner, W.; Schiefer, Hans-Gerd; Krauss, H; Jantos, Christian A.; Friedrich, H.; Altmannsberger, M.

doi:10.1007/bf01643680

Cited by 224 publications

(109 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GPs are thought to over-prescribe antibiotics for the treatment of prostatitis, as an infectious agent can only be detected in up to 10% of patients [5]. In over half of the present cases, the ®rst diagnosis of prostatitis had been made by a GP.…”

Section: Discussionmentioning

confidence: 86%

Epidemiology of prostatitis in Finnish men: a population‐based cross‐sectional study

et al. 2000

View full text Add to dashboard Cite

Objective To study the lifetime occurrence of prostatitis in Finnish men and their exposure to the disease. Subjects and methods A population-based cross-sectional survey was conducted in the two most northerly provinces of Finland (Oulu and Lapland). Altogether, 2500 male residents aged 20±59 years were chosen at random to complete a questionnaire on prostatitis. The data were collected between June 1996 and October 1997. Replies were received from 1832 men, giving a response rate of 75%. Results The overall lifetime prevalence of prostatitis was 14.2%. The risk of having or having had prostatitis increased with age, being 1.7 times greater in men aged 40±49 years than in those aged 20±39 years, and 3.1 times greater in those aged 50±59 years. The overall incidence was 37.8/10 000 person years. More than a quarter of the 261 men who had or had had prostatitis symptoms (27%) suffered from them at least once a year, while 16% suffered from persistent symptoms; 63% of the men with prostatitis had their worst symptoms during the winter (November-March). Neither education nor profession had much in¯uence on the occurrence of prostatitis, but divorced and single men had a lower risk than married men. Most patients felt they had not received enough information about the disease at their ®rst visit to a general practitioner. Conclusions The results of this survey showed that the occurrence of prostatitis symptoms in men living in northern Finland is higher than that reported in other parts of the world. This could be partly caused by the cold climate.

show abstract

Section: Discussionmentioning

confidence: 86%

Epidemiology of prostatitis in Finnish men: a population‐based cross‐sectional study

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Ps. aeruginosa is an infrequent cause of bacterial prostatitis (ranges from 0.3 to 3 % of cases) (Skerk et al, 2004;Weidner et al, 1991). Nevertheless, the virulence of Ps.…”

Section: Introductionmentioning

confidence: 99%

Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model

et al. 2009

View full text Add to dashboard Cite

Pseudomonas aeruginosa frequently acts as an opportunistic pathogen of mucosal surfaces; yet, despite causing aggressive prostatitis in some men, its role as a pathogen in the prostate has not been investigated. Consequently, we developed a Ps. aeruginosa infection model in the rat prostate by instilling wild-type (WT) Ps. aeruginosa strain PAO1 into the rat prostate. It was found that Ps. aeruginosa produced acute and chronic infections in this mucosal tissue as determined by bacterial colonization, gross morphology, tissue damage and inflammatory markers. WT strain PAO1 and its isogenic mutant PAO-JP2, in which both the lasI and rhlI quorum-sensing signal systems have been silenced, were compared during both acute and chronic prostate infections. In acute infections, bacterial numbers and inflammatory markers were comparable between WT PA01 and PAO-JP2; however, considerably less tissue damage occurred in infections with PAO-JP2. Chronic infections with PAO-JP2 resulted in reduced bacterial colonization, tissue damage and inflammation as compared to WT PAO1 infections. Therefore, the quorum-sensing lasI and rhlI genes in Ps. aeruginosa affect acute prostate infections, but play a considerably more important role in maintaining chronic infections. We have thus developed a highly reproducible model for the study of Ps. aeruginosa virulence in the prostate.

show abstract

“…However, with time, urologists and their patients became frustrated, not only with the classi®cation system but also with the diagnostic algorithm used to reach such a diagnosis [1]. Particularly frustrating was the concept of prostatodynia; several researchers believed that in many patients the symptoms were not related to the prostate at all [14]. The new classi®cation system [3,4] was similar to the traditional classi®cation system [13] in some aspects, e.g.…”

Section: Discussionmentioning

confidence: 99%

The value of endotoxin concentrations in expressed prostatic secretions for the diagnosis and classification of chronic prostatitis

Shen

et al. 2001

BJU International

View full text Add to dashboard Cite

Objective To clarify the value of endotoxin concentrations in expressed prostatic secretions (EPS) in the diagnosis and classi®cation of chronic prostatitis. Patients, subjects and methods The study included 88 consecutive patients with chronic prostatitis and 15 controls with no urological disease. The diagnosis and classi®cation were based on a history, symptoms, a digital rectal examination of the prostate, and a white blood cell count in the EPS. Endotoxin concentrations in the EPS or urine were measured using a colorimetric assay and standard microbiological methods used to identify bacterial growth. Results In men with chronic prostatitis caused by Gramnegative or combined Gram-negative and -positive bacteria, the endotoxin levels in urine collected immediately after prostatic massage were signi®cantly greater (P<0.01) than in a midstream urine sample, and the concentration in the EPS was signi®cantly higher (P<0.05) than that in the control group. The same was true of patients with chronic prostatitis and Gram-positive bacteria isolated from the EPS or urine after massage. In patients with chronic pelvic pain syndrome (grade IIIA) the endotoxin level in the urine after massage was also signi®cantly higher (P<0.05) than that of the midstream sample, but there was no signi®cant difference between the concentration in these samples in patients with grade IIIB, and no signi®cant difference between the endotoxin concentration of the EPS in patients with grade IIIB and that in controls. Conclusion Endotoxin concentrations are increased in the EPS or urine (after prostatic massage) of men with bacterial chronic prostatitis or chronic pelvic pain syndrome grade IIIA. The current routine examinations (including bacterial culture and routine examination of EPS or urine) before diagnosis and classi®cation of chronic prostatitis are insuf®cient to describe the cause and pathogenesis of this condition. The endotoxin concentration of the EPS or urine after massage may provide a supplementary tool to identify the cause of chronic prostatitis.

show abstract

Chronic prostatitis: A thorough search for etiologically involved microorganisms in 1,461 patients

Cited by 224 publications

References 27 publications

Epidemiology of prostatitis in Finnish men: a population‐based cross‐sectional study

Epidemiology of prostatitis in Finnish men: a population‐based cross‐sectional study

Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model

The value of endotoxin concentrations in expressed prostatic secretions for the diagnosis and classification of chronic prostatitis

Contact Info

Product

Resources

About