“…Activation of the canonical NF-kB pathway, which is induced by various stimuli, including TNF-a, is attenuated in HOIL-1L-knockout (KO) and cpdm (chronic proliferative dermatitis in mice) mice (Tokunaga et al, 2009(Tokunaga et al, , 2011Gerlach et al, 2011;Ikeda et al, 2011). The latter are spontaneous mutant mice that lack SHARPIN (Gallardo Torres et al, 1995). Moreover, cpdm mice show pleomorphic phenotypes, including chronic dermatitis and immune disorders (Gallardo Torres et al, 1995;HogenEsch et al, 1999;Seymour et al, 2006Seymour et al, , 2007, indicating a crucial role for LUBAC in canonical NF-kB activation (Tokunaga et al, 2009(Tokunaga et al, , 2011Gerlach et al, 2011;Ikeda et al, 2011).…”