Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells

Osame, Mitsuhiro; Matsumoto, Makoto; Usuku, Koichiro; Izumo, Shuji; Ijichi, Nobuhiro; Amitani, Hiroyoko; Tara, Mitsutoshi; Igata, Akihiro

doi:10.1002/ana.410210203

Cited by 598 publications

(219 citation statements)

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“…The mechanism by which myelopathy develops in HTLV-I infection has been studied intensively and several lines of evidence suggest that some immune-mediated mechanism damages the central nervous system (8,9). The characteristics of immunological findings in HAMpatients mimic those observed in autoimmunediseases.…”

Section: Discussionmentioning

confidence: 99%

“…TSHbinding inhibiting immunoglobulins (TBII) were measured by their ability to inhibit 125I-TSH binding to solubilized porcine TSH receptors (TRAb Kit, RSR Limited, Cardiff, UK) (normal range: <10%). Both the thyroid stimulating antibody (TSAb) and TSH stimulation-blocking antibody (TSBAb) were measured using cultured porcine thyroid cells (24 serum was examined for the first time and found to be positive, i.e., 8,192 xby the passive agglutination method and 1,280 xby the immunofluorescence method. HTLV-Iantibody was also positive in the cerebrospinal fluid ( l ,280x) by passive agglutination.…”

Section: Methodsmentioning

confidence: 99%

“…The geographic distribution ofHTLV-I infection is worldwide and the prevalence is strikingly high in southwest Japan, the Caribbean, Central Africa, and Melanesia. The mechanism by which spinal cord degeneration is caused by HTLV-I infection is considered to be immunologic (8,9). The association of Graves' disease with HAM is not incidental, because the incidence of manyother autoimmunediseases or immune-mediated diseases are high in HAM patients or HTLV-I carriers (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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Development of Graves' Ophthalmopathy and Uveitis after Radioiodine Therapy for Graves' Disease in a Patient with HTLV-I Associated Myelopathy (HAM).

et al. 1994

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HTLV-I carriers or patients with HTLV-I associated myelopathy (HAM)are prone to immune-mediated inflammatory disorders. Wepresent a 44-year-old female with HAMwho developed Graves' disease. She developed severe Graves' ophthalmopathy shortly after 131I therapy, concurrently with a remarkable increase in TSH-receptor antibody titer. Ophthalmopathy was aggravated in spite of prednisolone therapy and euthyroidism being maintained by thyroxine replacement. Uveitis also developed after 131I therapy and iridocyclitis finally required trabeculotomy. This case suggests that HAM patients may have a higher risk of immune-mediated Graves' ophthalmopathy after 131I therapy. (Internal Medicine 33: 564-568, 1994)

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Graves' Ophthalmopathy and Uveitis after Radioiodine Therapy for Graves' Disease in a Patient with HTLV-I Associated Myelopathy (HAM).

et al. 1994

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“…Patients with ATL have increased abnormal lymphocyte numbers and suffer from opportunistic infections as a result of compromised immune function. HAM/TSP is characterized by a slowly progressive paraparesis that is associated with spasticity (27)(28)(29).…”

Section: Human T Cell Lymphotropic Virus Type I Tax Activates Il-15r␣mentioning

confidence: 99%

Human T Cell Lymphotropic Virus Type I Tax Activates IL-15Rα Gene Expression Through an NF-κB Site

Mariner

Lantz

Waldmann

et al. 2001

The Journal of Immunology

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IL-15 mRNA levels are increased in diseases caused by human T cell lymphotropic virus type I (HTLV-I). In this study, we demonstrated that IL-15Rα, the IL-15-specific binding receptor, mRNA and protein levels were also elevated in HTLV-I-infected cells. We showed that transient HTLV-I Tax expression lead to increased IL-15Rα mRNA levels. In addition, by using a reporter construct that bears the human IL-15Rα promoter, we demonstrated that Tax expression increased promoter activity by at least 4-fold. Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-κB-binding motif in the human IL-15Rα promoter, suggesting that Tax activation of IL-15Rα is due, in part, to the induction of NF-κB. These data indicate that IL-15Rα is transcriptionally regulated by the HTLV-I Tax protein through the action of NF-κB. These findings suggest a role for IL-15Rα in aberrant T cell proliferation observed in HTLV-I-associated diseases.

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“…Los criterios para hacer el diagnóstico de paraparesia espástica tropical/mielopatía asociada al HTLV-I fueron aquellos descritos por Osame et al (1987) (3). Los individuos con leucemia de células T del adulto fueron referenciados de la historia clínica de remisión como caso de leucemia con diagnóstico serológico positivo para anticuerpos HTLV-I.…”

Section: Sujetos Y Muestrasunclassified

Síndrome autoinmune en la paraparesia tropical espástica/ mielopatía asociada a la infección por el virus linfotrópico humano tipo I de la costa pacífica colombiana

Domínguez¹,

Torres²,

Tamayo³

et al. 2008

biomedica

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Introducción. Trabajos previos han aportado evidencias de que en la paraparesia espástica tropical/mielopatía asociada con el virus linfotrópico humano tipo I, existe un componente autoinmune asociado a su patogénesis. Objetivo. Evaluar el estado autoinmune y la existencia de mimetismo molecular en pacientes con paraparesia espástica tropical del pacífico colombiano. Materiales y métodos. A partir de muestras de plasma de 37 pacientes con paraparesia espástica tropical/mielopatía asociada al HTLV-I, 10 con leucemia de células T del adulto, 22 individuos portadores asintomáticos y 20 seronegativos para el HTLV-I, se determinaron niveles plasmáticos de anticuerpos antinucleares y anticardiolipina-2 y de interferón-γ e interleucina-4. Se evaluó, por Western blot, la reactividad cruzada de plasmas contra proteínas obtenidas de varias fuentes celulares normales del sistema nervioso. Además, se estudió la reactividad cruzada de plasmas de seropositivos y del anticuerpo monoclonal LT4 anti-taxp40 en secciones de médula espinal de ratas Wistar no infectadas. Resultados. El 70,2% y el 83,8% de los pacientes con paraparesia espástica tropical fueron reactivos para anticuerpos ANA y ACL-2, respectivamente, en contraste con los de leucemia de células T del adulto y los seropositivos asintomáticos (P<0,001). Además, el 70,3% y el 43,2% de los pacientes con paraparesia espástica tropical tuvieron niveles detectables de IFN-γ e IL-4, respectivamente. El anticuerpo LT4 anti tax-p40 y los plasmas de paraparesia espástica tropical/mielopatía asociada al HTLV-I mostraron una reacción cruzada con una proteína de PM r 33-35 kDa, obtenida del núcleo de neuronas de la médula espinal de ratas Wistar no infectadas. Conclusión. Se obtuvieron evidencias que apoyan la existencia de un síndrome autoinmune mediado por mimetismo molecular como parte de la etiopatogénesis de la degeneración axonal observada en la paraparesia espástica tropical en pacientes colombianos de la costa pacífica.Palabras clave: paraparesia espástica, virus linfotrópico de células T humanas tipo 1, virus 1 T-linfotrópico de los primates, médula espinal, autoanticuerpos, autoinmunidad, imitación molecular.

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Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells

Cited by 598 publications

References 11 publications

Development of Graves' Ophthalmopathy and Uveitis after Radioiodine Therapy for Graves' Disease in a Patient with HTLV-I Associated Myelopathy (HAM).

Development of Graves' Ophthalmopathy and Uveitis after Radioiodine Therapy for Graves' Disease in a Patient with HTLV-I Associated Myelopathy (HAM).

Human T Cell Lymphotropic Virus Type I Tax Activates IL-15Rα Gene Expression Through an NF-κB Site

Síndrome autoinmune en la paraparesia tropical espástica/ mielopatía asociada a la infección por el virus linfotrópico humano tipo I de la costa pacífica colombiana

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