Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats

Soellner, Deborah; Grandys, Theresa; Nuñez, Joseph L.

doi:10.1016/j.bbr.2009.08.012

Cited by 55 publications

(37 citation statements)

References 49 publications

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“…No significant difference was observed in the body mass of the pups in the birthday. The consumption of caffeine by mothers during gestation has been associated with a low body mass of the pups at birth, or caused no alteration in the body mass of pups 15 . In addition, present results reinforce the hypothesis that caffeine has anorectic effects by promoting satiety and reducing body mass gain in the offspring 16 , since the caffeine-treated group presented a reduction in the food consumption and the body mass gain.…”

Section: Discussionmentioning

confidence: 99%

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

et al. 2014

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PURPOSE:To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring. METHODS:Twenty pregnant mice were divided into control group (c) and caffeine group (cf). dams received daily saline or 20 mg/kg of caffeine subcutaneously. Male offspring were monitored daily until 13 th week. The testis were used to evaluate both the proliferation (pcna) and apoptosis (bax); leptin receptor (ob-r); aromatase; follicle stimulating hormone (fshr), luteinizing hormone (lhr) and androgen receptors (ar); steroidogenic acute regulatory protein (star); vascular endothelial growth factor (vegf) and estrogen receptors (erα and erβ) by western blotting. Serum concentrations of testosterone, estradiol and leptin were measured. RESULTS:There was a significant reduction in food intake and the body mass gain (p<0.05) in the cf ; pcna (p=0.01), fshr (p=0.02), star (p=0.0007), vegf (p=0.009), ar (p=0.03) in the cf. while an increase were note in bax (p=0.01), ob-r (p=0.02), lhr (p=0.04) and in the aromatase (p=0.03) in the cf. only erα and erβ were not changed by maternal caffeine. The serum testosterone levels in the cf offspring were 90% lower than in the c offspring (p=0.04). CONCLUSION:Maternal caffeine consumption has a role and alters the testis of the offspring in adulthood.

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Section: Discussionmentioning

confidence: 99%

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

et al. 2014

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“…Gestational caffeine also downregulates central adenosine receptors (Leon et al, 2005;Lorenzo et al, 2010), reduces NMDA antagonist-induced locomotor activity (da Silva et al, 2005), and affects respiratory control (Bodineau et al, 2003;Saadani-Makki et al, 2004). Cognitive and motor deficits have also been reported in adult rodents exposed in caffeine during gestation and/or early postnatal life (Bjorklund et al, 2008;Soellner et al, 2009), although some impairments may be paradigm specific (Soellner et al, 2009).…”

Section: Caffeinementioning

confidence: 99%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

330

241

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Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, often differ from their effects on mature systems. In this review, we describe current knowledge on how alcohol, nicotine, cocaine, amphetamine, Ecstasy, and opiates (among other drugs) produce alterations in neurodevelopmental trajectory. We focus both on animal models and available clinical and imaging data from cross-sectional and longitudinal human studies. Early studies of fetal exposures focused on classic teratological methods that are insufficient for revealing more subtle effects that are nevertheless very behaviorally relevant. Modern mechanistic approaches have informed us greatly as to how to potentially ameliorate the induced deficits in brain formation and function, but conclude that better delineation of sensitive periods, dose-response relationships, and long-term longitudinal studies assessing future risk of offspring to exhibit learning disabilities, mental health disorders, and limited neural adaptations are crucial to limit the societal impact of these exposures.

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“…Since then, a number of studies have confirmed the negative effect of high doses of caffeine ingested during pregnancy both for the mother and the developing foetus [2,3,7,15,16,18,22,25,27,30,31].…”

Section: Introductionmentioning

confidence: 99%

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

et al. 2014

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Background: Caffeine is one of the most frequently ingested (at various tempe- Materials and methods: The research was conducted on rats. The fertilised females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30 mg/day) in 10 (E1), 25 (E2) and 45°C (E3). The females in the control group were given water at the same temperature (C 1 , C 2 and C 3 ). On the 21 st day of pregnancy, the pregnant females were killed by decapitation using a specially prepared laboratory guillotine and were assessed morphometric parameters of foetuses.Results and Conclusions: Based on this work showed that: the embryotoxic effect of caffeine was only confined to a reduction in the number of offspring; the greatest changes in the morphometric parameters occurred in foetuses whose mothers received caffeine at 10°C; in the control groups, the greatest changes were observed in foetuses whose mothers were given water at 10°C during pregnancy. (Folia Morphol 2014; 72, 3: 347-352)

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Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats

Cited by 55 publications

References 49 publications

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

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