Chronic plasma cell osteomyelitis of the humerus associated with Shigella and Flavobacterium

Kang, Lana; Millett, Peter J.; Mezera, Kimberly; Weiland, Andrew J.

doi:10.1067/mse.2001.113084

Cited by 7 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laboratory examination showed no abnormalities in many of the reported cases. [1][2][3][4] likewise in our case also immunologic studies revealed no abnormalities; this point is clinically different from solitary plasmacytoma. 1 In solitary myeloma there are a normal cell pattern of the sternal marrow, normal electrophoretic pattern of the plasma proteins and absence of Bence Jones protein in the urine.…”

Section: Discussionsupporting

confidence: 52%

“…While the cause in many cases remains unclear, the leading theory seems to suggest an occult infection, however, on review of literature, cultures have been positive in only 8% of cases in lesions involving bones other than the mandible. 4 Sampling errors or the indolence of the process may contribute to the low incidence of culture positivity. 4 In the examination of the causative organism of plasma cell osteomyelitis, Staphylococcus aureus had been proved in many cases as was with our case.…”

Section: Discussionmentioning

confidence: 99%

“…4 Sampling errors or the indolence of the process may contribute to the low incidence of culture positivity. 4 In the examination of the causative organism of plasma cell osteomyelitis, Staphylococcus aureus had been proved in many cases as was with our case. 1 This case of plasma cell osteomyelitis was atypical for reasons like involvement of the diaphysis, presence of sequestrum and culture positivity for Staphylococcus aureus.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the cases described in literature were managed with curettage of the lesion followed by a complete course of culture specific antibiotics. [1][2][3][4] We also advocated curettage of the lesion at the time of biopsy, followed by a course of culture-specific antibiotics (ofloxacin) for 4 weeks. Few cases described in literature were mistaken for a malignant bone tumour and were treated with wide resection and bone grafting.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A rare case of plasma cell osteomyelitis with atypical presentation

Meghalamane¹,

Kumar²,

Avinash³

et al. 2019

Int J Res Orthop

View full text Add to dashboard Cite

<p class="abstract">Plasma cell osteomyelitis is an uncommon type of localized chronic osteomyelitis which is characterized by the absence of typical clinical features of infection. It usually affects the metaphysis of long bones and presents as dense thickening of bone without sequestrum formation. We present an atypical case of plasma cell osteomyelitis with a lesion in the diaphysis of long bone and sequestrum formation<em>.</em> A 23 year old male patient came to our OPD with complaint of pain in mid-thigh radiating to the left knee since 2 months. X-ray showed radiolucencies in the medulla of middle third of shaft of femur along with a linear sequestrum suggestive of chronic osteomyelitis. An open biopsy was performed and surgical curettage was done. Histopathological examination was consistent with plasma cell osteomyelitis. Chronic plasma cell osteomyelitis is a rare condition with nonspecific findings and an unclear cause. Histopathology is the definitive tool for obtaining a diagnosis. Knowledge of this condition and proper management can give a better outcome, at the same time avoiding unnecessary investigations and procedures.</p>

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A rare case of plasma cell osteomyelitis with atypical presentation

Meghalamane¹,

Kumar²,

Avinash³

et al. 2019

Int J Res Orthop

View full text Add to dashboard Cite

show abstract

“…Moreover, Shigella can cause invasive infections such as meningitis and osteomyelitis. 16 , 17 In young children, intussusception or necrotizing enterocolitis is a common infection. 18 Currently, the most reliable treatment for these bacteria is antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Au Nanoclusters Ameliorate Shigella Infectious Colitis by Inducing Oxidative Stress

Wu¹,

Chen²,

Zhang³

et al. 2021

IJN

View full text Add to dashboard Cite

Background: Shigella infection has always been a global burden, and it particularly threatens children between the ages of 1 and 5 years. Economically underdeveloped countries are dominated by Shigella flexneri infection. The most effective method to treat Shigella is antibiotics, but with the abuse of antibiotics and the prevalence of multidrug resistance, we urgently need a relatively safe non-antibiotic treatment to replace it. Ultrasmall Au nanoclusters (NCs) have special physical and chemical properties and can better interact with and be internalized by bacteria to disrupt the metabolic balance. The purpose of this study was to explore whether Au NCs may be a substitute for antibiotics to treat Shigella infections. Methods: Au NCs and Shigella Sf301, R2448, and RII-1 were cocultured in vitro to evaluate the bactericidal ability of Au NCs. The degree of damage and mode of action of Au NCs in Shigella were clearly observed in images of scanning electron microscopy (SEM).In vivo experiments were conducted to observe the changes in body weight, clinical disease activity index (DAI) and colon (including length and histopathological sections) of mice treated with Au NCs. The effect of Au NCs was analysed by measuring the content of lipocalin-2 (LCN2) and Shigella in faeces. Next, the changes in Shigella biofilm activity, the release of reactive oxygen species (ROS), the changes in metabolism-related and membranerelated genes, and the effect of Au NCs on the body weight of mice were determined to further analyse the mechanism of action and effect. Results: Au NCs (100 μM) interfered with oxidative metabolism genes, induced a substantial increase in ROS levels, interacted with the cell membrane to destroy it, significantly killed Shigella, and effectively alleviated the intestinal damage caused by Shigella in mice. The activity of the biofilm formed by Shigella was reduced. Conclusion:The effective antibacterial effect and good safety suggest that Au NCs represent a good potential alternative to antibiotics to treat Shigella infections.

show abstract