Chronic Plaque Psoriasis Is Associated with Increased Arterial Stiffness

Gisondi, Paolo; Fantin, Francesco; Giglio, Micol Del; Valbusa, Filippo; Marino, Francesca; Zamboni, Mauro; Girolomoni, Giampiero

doi:10.1159/000182256

Cited by 117 publications

(113 citation statements)

References 41 publications

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“…It is demonstrated that psoriasis and psoriatic arthritis appear to be associated with an increased cardiovascular mortality and morbidity [56]. We and others have demonstrated an increase in the carotid-femoral (aortic) PWV [30,57].…”

Section: Psoriasismentioning

confidence: 86%

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Yıldız¹

2010

TOCMJ

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Abstract:The pulse wave velocity (PWV), as an indicator of arterial distensibility, may play an important role in the stratification of patients based on the cardiovascular risk. PWV inversely correlates with arterial distensibility and relative arterial compliance. Decreased arterial distensibility alters arterial blood pressure and flow dynamics, and disturbes coronary perfusion. Systemic immune and inflammatory diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased morbidity and mortality, predominantly due to adverse cardiovascular events. Systemic inflammation in these disorders may alter arterial compliance and arterial distensibility and, through this effect, lead to accelerated atherosclerosis. We have demonstrated an increase in the carotid-femoral (aortic) PWV that is a technique in which large artery elasticity is assessed from analysis of the peripheral arterial waveform, in patients with chronic inflammatory conditions such as RA, SLE, familial Mediterranean fever (FMF), Wegener's granulomatosis (WG), sarcoidosis, psoriasis and psoriatic arthritis except Behçet's disease (BD). In this review, the issue of arterial stiffness in RA, SLE, as well as WG, psoriasis, FMF, BD, sarcoidosis, systemic sclerosis (SS) and Takayasu's arteritis (TA) is overviewed.

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Section: Psoriasismentioning

confidence: 86%

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Yıldız¹

2010

TOCMJ

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“…Patients with severe psoriasis may have a higher risk of developing ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and NAFLD compared with controls (77)(78)(79)(80)(81)(82)(83)(84)(85). Patients with psoriasis are also more likely to have risk factors for vascular disease (e.g.…”

Section: The Relationship Between Psoriasis and Other Imidsmentioning

confidence: 99%

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

Girolomoni

Griffiths

Krueger

et al. 2014

Journal of Dermatological Treatment

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Psoriasis is an immune-mediated inflammatory disease (IMID) which may have a major impact on a patient's life, especially when the disease is moderate to severe. There is evidence that treatment of psoriasis during the first years is conservative and frequently based on topical agents which rarely clear lesions. Treatment with systemic agents including biologics is often undertaken only when topical agents have proved unsuitable, even in patients with moderate to severe disease. However, there is evidence that in other IMIDs (rheumatoid arthritis and Crohn's disease), targeted systemic treatment given early in the treatment pathway may improve long-term patient outcomes. We hypothesize that a patient-centered therapeutic approach, undertaken early in the psoriasis treatment pathway (''early intervention'') with the goal of complete clearance, may improve control of cutaneous symptoms and may also modify disease course and burden. Critical points to address when designing an early intervention study would include: the definition of psoriasis disease activity; patient selection; intervention selection; and dosing strategies.

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“…It was concluded that moderate to severe chronic plaque psoriasis might be independently associated with increased arterial stiffness. Psoriasis duration was thought to be a risk factor for arterial stiffness and atherosclerosis (26). In another study, the carotid-femoral pulse wave velocity was found significantly higher in psoriasis patients than in controls, even after adjustment for age, gender, and CV risk factors (27).…”

Section: Relationship Between Psoriasis and Cardiovascular Diseasesmentioning

confidence: 96%