Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats

Zanotti, A.; Valzelli, L.; Toffano, G.

doi:10.1007/bf00445550

Cited by 57 publications

(28 citation statements)

References 32 publications

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“…Zanotti et al (16) reported that the intraperitoneal injection of BC-PS restored scopolamine-induced amnesia in rats, which seemed to offer a clue to the anti dementia mechanism of phosphatidylserine. Because scopolamine is an acetyl choline receptor antagonist, the results in Table 4 suggest that SB-tPS affects on brain acetylcholine metabolism.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents.

Sakai

Yamatoya

Kudo

1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummarySoybean transphosphatidylated phosphatidylserine (SB -t PS) was prepared from soybean phosphatidylcholine by transphos phatidylation using phospholipase D, and the fatty acids composition and pharmacological properties were compared with those of bovine brain cortex-derived phosphatidylserine (BC-PS) which was reported to im prove cognitive disorders of senile dementia patients by oral administra tion (300mg/day). The molecular species of SB-tPS are rich in linoleic and palmitic acids whereas those of BC-PS are stearic and oleic acids. Despite the differences in fatty acid composition, SB-tPS displayed signifi cant activities on the increase in brain glucose concentrations in mice (79 mg/kg, i.v.) and the restoration of scopolamine-induced amnesia in rats (60mg/kg, i.p.) as did BC-PS. These results suggest the possibility that SB-tPS may prevent and/or improve senile dementia by oral administra tion.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents.

Sakai

Yamatoya

Kudo

1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…After Toffano and Bruni reported in 1980 that brain cortex phosphatidylserine (B-PS), a pharmacologically active phospholipid, counteracts age-related changes in the central nervous system (CNS) (1), many investigators have observed that exogenous B-PS affects neurotrans mission (2-4) and behavioral performance (5,6) by modifying the composition and function of the neuronal membrane, which is associated with aging (7). Clinical investigations have also shown that B-PS treatment can improve Alzheimer's disease (AD) and related cognitive disorders (8,9).…”

mentioning

confidence: 99%

“…Although there is as yet little direct evidence that SB-tPS involves central cholinergic mechanisms, these results suggest that the anti-amnesia effect of SB-tPS could be attributed to the activation of cholinergic neu ronal systems in the CNS. Indeed, regarding mechanism of B-PS, several investigators have proposed a cholinergic mechanism based on the findings that the acute adminis tration of B-PS antagonizes the amnesic effects of SCP on spontaneous alternation and passive avoidance (5,6).…”

mentioning

confidence: 99%

Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Furushiro

Shishido

Sakai

et al. 1997

Japanese Journal of Pharmacology

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ABSTRACT-Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cyclohex imide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.

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“…Also, other experiments have shown an improvement in memory, learning capacity, and other cognitive parameters in PS-supplemented rodents [7][8][9][10][11]. This is plausible, since PS was found to stimulate neurotransmitter release [7,12], increase brain glucose metabolism [13,14] and reduce oxidative stress in the brain [15].…”

Section: Phosphatidylserine (Ps) and Phosphatidic Acid (Pa) In Memorymentioning

confidence: 88%

Soy Lecithin-Derived Phosphatidylserine Plus Phosphatidic Acid: Effects on Brain Functions in Elderly Patients with Alzheimer's Disease and Dementia

Moré¹,

Rutenberg²

2017

J Aging Sci

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Phosphatidic acid (PA) and phosphatidylserine (PS) and are natural constituents of healthy brain cell membranes, which have been recognized since the 1970s as essential to normal neuronal functioning. PA is a precursor in the formation of other phospholipids, including PS and phosphatidylethanolamine (PE). Also, it has an impact on membrane rigidity/flexibility, which is important in modulating exo-and endocytosis. PS is also an important precursor for PE synthesis. Since PS predominantly occurs in brain cells, but normal diets do not include the consumption of brains, PS is available to our brains mostly via natural "production" in our bodies.Here, we present a tabulated literature survey of clinical studies on PS and/or PA regarding brain function in elderly people. In addition we give a summary on two of our our already published pilot studies performed with a brain-health food supplement containing a proprietary blend of 100 mg PS and 80 mg PA produced from soy lecithin: A three-month double-blind, placebo-controlled study demonstrated the positive influence of three PS+PA capsules/ day, (300 mg PS+240 mg PA per day; n=40)) or placebo (n=32) on memory and mood in functioning, non-depressive elderly people with memory problems. In a two-month randomized, double-blind, placebo-controlled study, three PS+PA capsules/day (300 mg PS+240 mg PA per day; n=56) or placebo (n=40) improved daily functioning, mental health, emotional state, and self-reported general condition in patients with Alzheimer's disease (AD).Altogether there is encouraging clinical data that PS+PA supplementation could be beneficial to AD patients and other elderly people with memory or cognition problems. Long-term studies are, however, still lacking. Keywords: Phosphatidylserine (PS) and Phosphatidic Acid (PA) in MemoryThe membrane phospholipids phosphatidic acid (PA) and phosphatidylserine (PS) are essential to cellular functioning, acting as a biological detergent, keeping fatty substances soluble and cell membranes flexible [1,2]. During the pathogenesis of several age-related neurodegenerative diseases, including Alzheimer's disease, the neuronal membrane lipid composition is altered in the brain [3,4]. Also, the lipid raft composition appears to be altered in neurodegenerative diseases [5]. PS (and PA), produced by enzymatic conversion of soybean lecithin, avoids possible regulatory and safety issues regarding bovine spongiform encephalopathy. Soy lecithin-derived PS is absorbed and metabolized, with elevated serum levels for at least 1.5 hours after an oral dose, as has been shown within a kinetic study on 8 human volunteers. The baseline serum level of PS in relation to the level of total serum phospholipids was around 2%. 30 minutes after ingestion, it started to increase, peaking at 90 minutes after intake at around 4%, and returning to the basal level 180 minutes after intake [23].Recently, oral administration of phosphatidylcholine/phosphatidylethanolamine (PE) -transphosphatidylated PS has been shown to improve memory imp...

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Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats

Cited by 57 publications

References 32 publications

Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents.

Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents.

Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Soy Lecithin-Derived Phosphatidylserine Plus Phosphatidic Acid: Effects on Brain Functions in Elderly Patients with Alzheimer's Disease and Dementia

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