Chronic peritoneal dialysis in children

Madden, Iona; Blaauw, Michelle; Baugh, Natasha; Rees, Lesley; Shroff, Rukshana

doi:10.1016/j.paed.2020.06.005

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Moreover, patients on PD reported a better quality of life when compared with HD [ 7 ]. These features make PD especially suitable for pediatric patients with ESKD, in whom PD may have the potential to allow a relatively normal life [ 8 ]. However, despite these positive aspects, PD is not risk-free.…”

Section: Introductionmentioning

confidence: 99%

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

Trincianti

Meleca

Porta

et al. 2022

IJMS

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Peritoneal dialysis (PD) represents the dialysis modality of choice for pediatric patients with end-stage kidney disease. Indeed, compared with hemodialysis (HD), it offers many advantages, including more flexibility, reduction of the risk of hospital-acquired infections, preservation of residual kidney function, and a better quality of life. However, despite these positive aspects, PD may be associated with several long-term complications that may impair both patient’s general health and PD adequacy. In this view, chronic inflammation, caused by different factors, has a detrimental impact on the structure and function of the peritoneal membrane, leading to sclerosis and consequent PD failure both in adults and children. Although several studies investigated the complex pathogenic pathways underlying peritoneal membrane alterations, these processes remain still to explore. Understanding these mechanisms may provide novel approaches to improve the clinical outcome of pediatric PD patients through the identification of subjects at high risk of complications and the implementation of personalized interventions. In this review, we discuss the main experimental and clinical experiences exploring the potentiality of the proteomic analysis of peritoneal fluids and extracellular vesicles as a source of novel biomarkers in pediatric peritoneal dialysis.

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Section: Introductionmentioning

confidence: 99%

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

Trincianti

Meleca

Porta

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…Continuous ambulatory peritoneal dialysis (CAPD) is a well-known management technique for paediatric Stage 5 chronic kidney disease (CKD-5) used worldwide. 1,2 However, the majority of children in Pakistan are dialysed by haemodialysis (HD), and very few receive successful kidney transplants. CAPD is rarely practiced in Pakistan due to the scarcity of costly dialysis consumables and a lack of education and trained staff.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus terreus Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis: A Case Report from Pakistan

Moin

Moorani

Qureshi

2022

EMJ Microbiol Infect Dis

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Background: Aspergillus peritonitis is a rare, potentially fatal complication of continuous ambulatory peritoneal dialysis (CAPD). Several cases of fungal peritonitis (FP) caused by Aspergillus species have been reported worldwide; however, there is a paucity of data from Pakistan. Here, a case of congenital nephrotic syndrome is reported in a patient who progressed to Stage 5 chronic kidney disease when she was 8 years old, which was managed by CAPD and other supportive therapies. The patient developed FP and later succumbed to death despite appropriate management. Early diagnosis and careful interpretation of culture results are, therefore, important for the treatment of these patients. Case presentation: The patient outlined in this case report had congenital nephrotic syndrome, Stage 5 chronic kidney disease, and was on CAPD. She presented with peritonitis. Initially, broad spectrum antibiotics were started, and peritoneal samples did not yield any growth. Later, consecutive peritoneal samples taken from the patient grew Aspergillus terreus, with septate hyphae seen on a direct smear from the sample. Voriconazole was started immediately, and the patients’ catheter was removed. However, the patient’s condition deteriorated and, after prolonged intensive care and high ventilator support, the patient expired. Conclusion: A. terreus is an uncommon and deadly pathogen that does not respond to the commonly used antifungal treatments such as amphotericin B. The treatment of CAPD-related FP requires early diagnosis and the use of newer drugs such as voriconazole or caspofungin.

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Continuous peritoneal dialysis in pediatric patients with chronic kidney diseases: a case series and literature review

Sibarani,

Soetandar

2023

F1000Res

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Background: Continuous ambulatory peritoneal dialysis (CAPD) is still a viable option for pediatric renal replacement therapy in both acute and chronic conditions. In a country with limited resources, CAPD is still the treatment of choice for pediatric patients with end stage chronic kidney disease (CKD). Case presentation: We present a case series of six children with chronic kidney diseases on continuous ambulatory peritoneal dialysis (CAPD (age range: 10–16 years old). All patients were diagnosed with CKD stage 5. Of the six patients, four were diagnosed with nephrotic syndrome, one with systemic lupus erythematosus with kidney involvement, 1 with primary glomerulopathy, and one was diagnosed with congenital anomaly of a kidney. In this study, most patients experienced infection as the side effect of CAPD (n = 4; 66.67%), while the remainings experienced adhesion (n = 2; 33.33%). CAPD was effective in 4 of 6 patients who received the device. Discussion: Due to the emergence of complications, the lack of long-term efficacy of CAPD is the most significant factor limiting its application. Conclusion: The authors report a case series of successful experience with CAPD in children with CKD in Indonesia. Although CAPD is effective, the majority of patients in this series do not survive.

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Chronic peritoneal dialysis in children

Cited by 3 publications

References 7 publications

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

Aspergillus terreus Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis: A Case Report from Pakistan

Continuous peritoneal dialysis in pediatric patients with chronic kidney diseases: a case series and literature review

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