Chronic Paroxysmal Hemicrania: Continued Remission of Symptoms after Discontinuation of Indomethacin

Abstract

Discontinuation of indomethacin in chronic paroxysmal hemicrania (CPH) usually causes relapse of symptoms within a few days. A patient with characteristic symptoms of CPH is reported. The patient had daily attacks of unilateral headache accompanied by ipsilateral lacrimation and conjunctival injection, a frequency of attacks between four and fourteen per day, and never a headache-free day. He was treated with indomethacin, and all symptoms disappeared within 24 h. After three months indomethacin was discontinued. Six months after that the patient was still symptom-free.

Episodic Paroxysmal Hemicrania: 3 New Cases and a Review of the Literature

“…2,15 Patients with atypical clinical features 16,17 or in whom treatment with indomethacin induced prolonged remission in patients with CPH, were also not included. 18,19 Periods of daily headaches were separated by discrete periods of pain-free remissions. Table 1 summarizes the demographic features of EPH.…”

Trigeminal Otonomik Sefaljilerde Tedavi

“…‹ndomethacin kesildi¤inde ise, ço¤unlukla 12 saat ile birkaç gün aras›nda semptomlar tekrar ortaya ç›kar. Zamanla indomethacin'in terapötik etkinli¤inin azald›¤› vakalar bulunmakla beraber, indomethacin kesildikten sonra uzun süreler remisyonda kalan hastalar da mevcuttur (53).…”

Chronic Paroxysmal Hemicrania (CPH): Nomenclature as Far as The Various Stages are Concerned

“…Around this time, however, another development took place: Stein & Rogado (3) were the first to describe two patients with a clinical picture similar or identical to that of CPH, but observed within a non-chronic stage. Several cases in this category have been observed since then (4,5). Because some of the cases have been stable in the non-chronic stage for a number of years, we may sooner or later be faced with the situation that these cases will never reach the chronic stage.…”