Chronic Pain in Relation to Depressive Disorders and Alcohol Abuse

Maleki, Nasim; Oscar‐Berman, Marlene

doi:10.3390/brainsci10110826

Cited by 11 publications

(9 citation statements)

References 46 publications

(64 reference statements)

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“…However, it is not clear whether psychiatric comorbidities burden on endometriosis or whether they are the consequence of painful symptoms. Nevertheless, it is not difficult to figure out that chronic pain as well as impaired psychological well-being may encourage alcohol misuse 60,61 . Alcohol consumption could be framed as a possible wrong selfmedication to cope with either stressful or painful events.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

Piani

Chiaffarino

Cipriani

et al. 2022

Sci Rep

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Endometriosis is a complex and chronic disease, whose multifactorial nature has encouraged a deep investigation on the role of lifestyle factors. A strong association between alcohol intake and endometriosis risk has already been shown. We aimed to confirm this association, considering the updated literature. 23 eligible studies were identified through comprehensive literature search of PubMed and EMBASE (May 2012–October 2021). A borderline statistical significance was found comparing any alcohol consumption with no consumption (unadjusted OR 1.14; 95% CI: 0.99–1.31, p = 0.06), in contrast with a previous meta-analysis. However, we confirmed the significant association between moderate alcohol intake and endometriosis (unadjusted OR 1.22, 95% CI: 1.03–1.45, p = 0.02), also performing a sensitivity analysis (unadjusted OR 1.27, 95% CI: 1.04–1.54). Our partly divergent evidence reflects the tough challenge of isolating the impact of specific factors on the natural history of multifactorial diseases. Indeed, on one hand alcohol could be adopted by patients as a self-management therapy and on the other, it could favor the disease, promoting positive feedback with inflammatory mediators and oxidative stress. Our study encourages further investigation on the role of modifiable lifestyle factors and highlights the opportunity to adopt them to prevent or at least limit endometriosis progression.

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Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

Piani

Chiaffarino

Cipriani

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Our results also revealed that alcohol intake by males with depressive symptoms did not significantly differ between the non-CP and CP groups. A cohort study by Maleki et al [ 41 ] reported a relationship between depression and CP with or without alcohol abuse. The novel result of the present study is that depression and CP were associated with a low alcohol intake.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Alcohol Intake and Chronic Pain with Depressive Symptoms: A Cross-Sectional Analysis of the Shika Study

Amatsu

Tsujiguchi

Hara

et al. 2022

IJERPH

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Although alcohol intake is associated with chronic pain (CP) and analgesia, epidemiological studies have not yet examined the factors affecting the relationship between alcohol intake and CP in detail. Therefore, the present cross-sectional study investigated the relationship between alcohol intake and CP in community-dwelling middle-aged and elderly individuals with/without depressive symptoms. Participants comprised 2223 inhabitants of Shika town in Ishikawa prefecture, located on the Noto Peninsula facing the Sea of Japan, and included 1007 males and 1216 females. CP, depressive symptoms, and alcohol intake were assessed using a CP questionnaire, the Geriatric Depression Scale-15 and the brief-type self-administered diet history questionnaire, respectively. In males without depressive symptoms, mean alcohol intake was significantly higher at 5.70% energy (27.92 g/day) in the CP group than that of 3.75% energy (20.00 g/day) in the non-CP group. The prevalence of low back/knee pain was also significantly higher in males with than in those without depressive symptoms. The present results suggest that long-term alcohol intake is related to CP by reducing the pain threshold and enhancing nociceptive pain as a possible mechanism. However, even a low alcohol intake was associated with psychogenic pain in participants with depressive symptoms. Further studies to investigate the involvement of depressive symptoms and alcohol intake in CP and its prevention are needed.

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“…In retrospect, this seems a substantial oversight. For example, the neurobiology of both chronic pain and harmful alcohol use (e.g., Alcohol Use Disorder) are interrelated in terms of etiological and neurobiological factors 21,45,46 .…”

Section: Discussionmentioning

confidence: 99%