Objective-The purpose of this analysis is to report the incremental costs and benefits of different doses of spinal manipulative therapy (SMT) in patients with chronic low back pain (LBP).Methods-We randomized 400 patients with chronic LBP to receive a dose of 0, 6, 12, or 18 sessions of SMT. Participants were scheduled for 18 visits over 6 weeks and received SMT or light massage control from a doctor of chiropractic. Societal costs in the year following study enrollment were estimated using patient reports of healthcare utilization and lost productivity. The main health outcomes were the number of pain-free days and disability-free days. Multiple regression was performed on outcomes and log-transformed cost data.Results-Lost productivity accounts for a majority of societal costs of chronic LBP. Cost of treatment and lost productivity ranged from $3398 for 12 SMT sessions to $3815 for 0 SMT sessions with no statistically significant differences between groups. Baseline patient characteristics related to increase in costs were greater age (P=0.03), greater disability (P=0.01), lower QALY scores (P=0.01), and higher costs in the period preceding enrollment (P<0.01). Painfree and disability-free days were greater for all SMT doses compared to control, but only SMT 12 yielded a statistically significant benefit of 22.9 pain-free days (P=0.03) and 19.8 disability-free days (P=0.04). No statistically significant group differences in QALYs were noted. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-A dose of 12 SMT sessions yielded a modest benefit in pain-free and disabilityfree days. Care of chronic LBP with SMT did not increase the costs of treatment plus lost productivity.
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