Chronic Pain and DepressionAmong Primary Care Patients Treated with Buprenorphine

Stein, Michael D.; Herman, Debra S.; Bailey, Genie L.; Straus, John; Anderson, Bradley J.; Uebelacker, Lisa A.; Weisberg, Risa B.

doi:10.1007/s11606-015-3212-y

Cited by 38 publications

(33 citation statements)

References 65 publications

(85 reference statements)

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“…The compound best studied in this context is buprenorphine, which is a partial μ receptor agonist with a weak κ receptor antagonistic profile. Buprenorphine was found to produce antidepressant and anxiolytic effects in mice, which were mediated through the κ receptor (Falcon et al , ), although clinical observations in chronic pain patients treated with buprenorphine failed to detect lasting mood effects (Stein et al , ). Overall, compounds simultaneously targeting μ and κ receptors, either as agonist/agonist or agonist/antagonist, have shown some clinical efficacy, although the main limitations of chronic μ receptor activation, such as abuse liability, constipation and respiratory depression, are still apparent.…”

Section: Rationale For the Development Of Multi‐targeting Opioid Ligandsmentioning

confidence: 99%

Targeting multiple opioid receptors – improved analgesics with reduced side effects?

Günther

Dasgupta

Mann

et al. 2017

British J Pharmacology

142

131

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Section: Rationale For the Development Of Multi‐targeting Opioid Ligandsmentioning

confidence: 99%

Targeting multiple opioid receptors – improved analgesics with reduced side effects?

Günther

Dasgupta

Mann

et al. 2017

British J Pharmacology

142

131

View full text Add to dashboard Cite

show abstract

“…Up to 62% of OMT patients endorse chronic pain (Jamison et al, 2000; Rosenblum et al, 2003; Ilgen et al, 2006; Barry et al, 2008, 2009b; Dunn et al, 2014; Stein et al, 2015; Voon et al, 2015), compared to 30.7% in the general population (Johannes et al, 2010) and there is also growing evidence that OMT patients may have a different experience of pain relative to the general population. Many OMT patients show signs of opioid-induced hyperalgesia, a super-sensitivity to pain that is hypothesized to occur following extended exposure to opioid agonists (Brush, 2012).…”

Section: Introductionmentioning

confidence: 99%

Characterizing pain and associated coping strategies in methadone and buprenorphine-maintained patients

Dunn

Finan

Tompkins

et al. 2015

Drug and Alcohol Dependence

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Background Chronic pain is common among patients receiving opioid maintenance treatment (OMT) for opioid use disorder. To aid development of treatment recommendations for coexisting pain and opioid use disorder, it is necessary to characterize pain treatment needs and assess whether needs differ as a function of OMT medication. Methods A point-prevalence survey assessing pain and engagement in coping strategies was administered to 179 methadone and buprenorphine-maintained patients. Results Forty-two percent of participants were categorized as having chronic pain. Methadone patients had greater severity of pain relative to buprenorphine patients, though both groups reported high levels of interference with daily activities, and participants with pain attended the emergency room more frequently relative to participants without pain. Only 2 coping strategies were being utilized by more than 50% of participants (over-the-counter medication, prayer). Conclusions Results indicate that pain among OMT patients is common, severe, and of significant impairment. Methadone patients reported greater severity pain, particularly worse pain in the past 24 hours, though interference from pain in daily activities did not vary as a function of OMT. Most participants with pain were utilizing few evidenced-based pain coping strategies. Increasing OMT patient access to additional pain treatment strategies is an opportunity for immediate intervention, and similarities across OMT type suggest interventions do not need to be customized to methadone vs. buprenorphine patients.

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“…It has been demonstrated that similar to the MMT patient population, a large proportion of OUD patients with other medication-assisted treatments (e.g., buprenorphine and naloxone) also report chronic pain Mark, Dilonardo, Vandivort, & Miller, 2013;Stein et al, 2015). However, the extent to which findings from our study are generalizable to patients with OUD who receive other forms of medication-assisted treatment is currently unclear.…”

mentioning

confidence: 72%

Pain catastrophizing and pain acceptance are associated with pain severity and interference among methadone‐maintained patients

Mun¹,

Beitel

Oberleitner

et al. 2019

J Clin Psychol

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Objective The present study examined whether pain catastrophizing and pain acceptance, two important targets of psychosocial interventions for chronic pain, are uniquely associated with pain severity and pain interference among patients on methadone maintenance treatment (MMT). Method A total of 133 MMT patients who reported experiencing some pain during the previous week completed a battery of self‐report measures. Multiple regression was used to test whether pain catastrophizing and pain acceptance are related to pain severity and pain interference above and beyond covariates including demographics, emotional distress, and current methadone dose. Results Both pain acceptance and catastrophizing were significantly associated with pain severity and pain interference while controlling for covariates. Conclusions Consistent with previous literature on patients with chronic pain but without opioid use disorder, our findings suggest that both pain catastrophizing and pain acceptance are potentially important intervention targets among MMT patients with co‐occurring opioid use disorder and chronic pain.

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Chronic Pain and DepressionAmong Primary Care Patients Treated with Buprenorphine

Cited by 38 publications

References 65 publications

Targeting multiple opioid receptors – improved analgesics with reduced side effects?

Targeting multiple opioid receptors – improved analgesics with reduced side effects?

Characterizing pain and associated coping strategies in methadone and buprenorphine-maintained patients

Pain catastrophizing and pain acceptance are associated with pain severity and interference among methadone‐maintained patients

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