Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease

Docosahexaenoic Acid (DHA), Vitamin D3, and Probiotics Supplementation Improve Memory, Glial Reactivity, and Oxidative Stress Biomarkers in an Aluminum-Induced Cognitive Impairment Rat Model

“…The study assessed the effects of VD3, probiotics, and DHA, both individually and in combinations, in a rat model with cognitive impairment induced by aluminum chloride. Aluminum exposure is known to induce neuronal degeneration, particularly in the cholinergic system, leading to clinical and pathological characteristics resembling those observed in neurological diseases such as Alzheimer’s disease . Here, MWM and NOR tests were performed to assess the cognitive capacity after Al and treatments administration.…”

“…Aluminum exposure is known to induce neuronal degeneration, particularly in the cholinergic system, leading to clinical and pathological characteristics resembling those observed in neurological diseases such as Alzheimer’s disease. 32 Here, MWM and NOR tests were performed to assess the cognitive capacity after Al and treatments administration. The results indicate that the administration of various treatments had an impact on the parameters assessed in both behavioral tests.…”

A new “turn-on” molecular switch for idiosyncratic detection of Al3+ ion along with its application in live cell imaging

“…11 Abnormal concentration of Al in the human body is related to many neurological disorders including Alzheimer's disease, Parkinson's disease and dementia. 12–14 On the other hand, regular intake of Al beyond permissible limits causes bone disease, damage in the gastrointestinal tract, encephalopathy, microcytic hypochromic anaemia, myopathy, bone softening, impaired lung function, fibrosis and chronic renal failure. 15–18 Therefore, it is imperative to develop probes that can detect and track aluminium ions with high sensitivity using minimal resources and under biological conditions.…”