Chronic Occlusion of the Portal Vein

Simonds, J. P.

doi:10.1001/archsurg.1936.01190030050003

Cited by 27 publications

(6 citation statements)

References 15 publications

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“…(a) Hepatofugal: Found typically in intra-hepatic obstruction e. g. in portal cirrhosis and consist of esophageal and haemorrhoidal varices or collaterals at other sites of porto-systemic proximity and at the site of the obliterated foetal circulation [10].…”

Section: Discussionmentioning

confidence: 99%

“…(2) Recanalization of thrombosed portal veins forming cavernous mass. Simonds [10] reviewing the causes of death in 95 cases of vein obstruction showed that in 55 cases belonging to group (a) the ob struction was intra-hepatic and the main cause of death was gastro intestinal haemorrhage. In the second group of 40 cases (including cases previously reported by Klemperer [5] and others, the obstruc tion was extra-hepatic and the main cause of death was intestinal infarction [2,5,7,10].…”

Section: Discussionmentioning

confidence: 99%

“…The following case, while showing few of the usual features and complications of portal obstruction, falls into the second group de scribed by Pick [8] and Simonds [10] (see below).…”

Section: By a E Idelm Anmentioning

confidence: 95%

“…Neonatal umbilical sepsis and pylephlebi tis [11]. V. Acquired occlusion of portal vein [2,7,9,10,13].…”

Section: By a E Idelm Anmentioning

confidence: 99%

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Cavernous Transformation of the Portal Vein

Eidelman¹

1967

Digestion

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The following case, while showing few of the usual features and complications of portal obstruction, falls into the second group de scribed by Pick [8] and Simonds [10] (see below).…”

Section: By a E Idelm Anmentioning

confidence: 95%

“…Neonatal umbilical sepsis and pylephlebi tis [11]. V. Acquired occlusion of portal vein [2,7,9,10,13].…”

Section: By a E Idelm Anmentioning

confidence: 99%

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Cavernous Transformation of the Portal Vein

Eidelman¹

1967

Digestion

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“…The most marked elastic tissue changes in the media were noted where there was extensive intimal thrombosis, suggesting that the thrombosis too was a result of this same factor, probably prolonged and excessive pressure in the vein. However, the occurrence of thrombosis in a vein depends on so many factors (Rosenthal, 1925;Evans, 1929;Simonds, 1936;Reich, 1942), and the fact that the muscular hypertrophy was sometimes most marked below the greatest intimal thickening, combine to make it difficult to decide the relative importance of these findings. In spite of this, and since in the cases with intimal thrombosis the muscle coats and elastic tissue were also markedly hypertrophied, it seems reasonable to suggest that these changes are the result of prolonged congestion.…”

Section: Relationship Between Changes In Portal and Splenic Veins Andmentioning

confidence: 99%

Changes in the portal and splenic veins in portal hypertension and their relation to splenomegaly

Wilson¹

1961

Gut

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SYNOPSIS This paper is a pathological study on the portal veins demonstrating that the changes in the portal circulation and in the spleen reflect the degree or duration of portal hypertension.Cirrhosis of the liver has been known for many years to be accompanied by changes in the portal venous system and the spleen, and they were thought to be secondary to the congestion brought about by the distortion of the lobular pattern in the liver; somewhat similar changes occur in the absence of cirrhosis of the liver when the portal or splenic veins are blocked. The congestion gives rise to an increase in pressure in the vein (portal hypertension) and the development of a collateral circulation. Banti (1898) described the changes in the portal vein as a phlebosclerosis, and later Pei-Lin Li (1940), studying the pathological changes in the vein wall in greater detail, considered that the medial hypertrophy and intimal thickening were due to an increase in pressure in the vein.In the hope that examination of the portal and splenic veins would give some indication as to the extent or duration of the congestion, portions of these veins were obtained from cases with cirrhosis of the liver and portal congestion with splenomegaly, then carefully studied. The pathological changes in them were noted and correlated with the other lesions, including the size of the spleen. A liver was taken to be cirrhotic if the following changes were seen: 1, Obvious nodularity, 2, an excess of fibrous tissue throughout, and 3, marked distortion of the lobular architecture. MATERIAL AND METHODSSections of the portal and splenic veins were examined from 30 cases of cirrhosis of the liver, and from the splenic vein in seven cases in which splenectomy had been performed for recurrent haematemeses or splenomegaly. One of the latter subsequently came to necropsy so that in it the portal vein also was available for study. The microscopic appearance of the portal and splenic

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