Chronic obstructive pulmonary disease is not a risk factor for polyneuropathy: A prospective controlled study

Visser, Nora A.; Notermans, Nicolette C.; Berkhout, F. Teding van; Berg, Leonard H van den; Vrancken, Alexander F.J.E.

doi:10.1177/1479972316636993

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…Another indirect link between ischemia and CIAP consists of the reports of a higher frequency of polyneuropathy in patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea ( 42 – 46 ). However, in a large case–control study, the prevalence of COPD in CIAP patients was not higher compared to controls ( 47 ).…”

Section: Microangiopathy In Sural Nerve Biopsies From Patients With Omentioning

confidence: 98%

Microangiopathy—A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review

Samuelsson

2018

Front. Neurol.

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Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. In this mini review, we focus on the hypothesis of disturbed microcirculation in the vasa nervorum of peripheral nerves as a pathogenic cause of CIAP. There is an association between CIAP and metabolic risk factors. Furthermore, the phenotype of CIAP resembles diabetic neuropathy both clinically and electrophysiologically. In sural nerve biopsies from patients with diabetes mellitus, structural abnormalities indicating microangiopathy in the endoneurial microvessels are well documented. Similarly, sural microvessel abnormalities have been shown in patients with atherosclerotic non-diabetic peripheral vascular disease. However, the reported histopathological alterations of microvasculature in sural nerves of CIAP patients are inconsistent. Two studies report microangiopathic changes in CIAP sural nerves comparable with those found in patients with diabetic neuropathy. Conversely, another recent study showed no significant differences in the microangiopathic parameters in the endoneurial microvessels in the sural nerve biopsies from CIAP patients compared to controls without polyneuropathy. However, this CIAP patient group was younger compared to the patient groups in the other two studies. A general limitation with the published morphological studies are that different methods have been used in the assessment of microangiopathy, and there is also a risk of subjectivity in the results. Immunohistochemistry studies of sural nerves with verification of microangiopathy using specific biomarkers would be of great interest to develop.

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Section: Microangiopathy In Sural Nerve Biopsies From Patients With Omentioning

confidence: 98%

Microangiopathy—A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review

Samuelsson

2018

Front. Neurol.

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“…In this respect, in stable COPD BE seems to be a marker of long-term distortions of the internal environment that are important for various comorbidities including peripheral neuropathy. Possibly, in this regard BE is superior to spirometric lung function that has not been found to be associated with polyneuropathy if taken as only characteristic of COPD [46]. Metabolic factors, i.e.…”

Section: Discussionmentioning

confidence: 98%

The impact of COPD on polyneuropathy: results from the German COPD cohort COSYCONET

et al. 2020

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Background Peripheral neuropathy is a common comorbidity in COPD. We aimed to investigate associations between alterations commonly found in COPD and peripheral neuropathy, with particular emphasize on the distinction between direct and indirect effects. Methods We used visit 4 data of the COPD cohort COSYCONET, which included indicators of polyneuropathy (repeated tuning fork and monofilament testing), excluding patients with diabetes a/o increased HbA1c. These indicators were analysed for the association with COPD characteristics, including lung function, blood gases, 6-min walk distance (6-MWD), timed-up-and-go-test (TUG), exacerbation risk according to GOLD, C-reactive protein (CRP), and ankle-brachial index (ABI). Based on the results of conventional regression analyses adjusted for age, BMI, packyears and gender, we utilized structural equation modelling (SEM) to quantify the network of direct and indirect relationships between parameters. Results 606 patients were eligible for analysis. The indices of polyneuropathy were highly correlated with each other and related to base excess (BE), ABI and TUG. ABI was linked to neuropathy and 6-MWD, exacerbations depended on FEV1, 6-MWD and CRP. The associations could be summarized into a SEM comprising polyneuropathy as a latent variable (PNP) with three measured indicator variables. Importantly, PNP was directly dependent on ABI and particularly on BE. When also including patients with diabetes and/or elevated values of HbA1c (n = 742) the SEM remained virtually the same. Conclusion We identified BE and ABI as major determinants of peripheral neuropathy in patients with COPD. All other associations, particularly those with lung function and physical capacity, were indirect. These findings underline the importance of alterations of the micromilieu in COPD, in particular the degree of metabolic compensation and vascular status.

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“…However, in addition to the increased incidence of axonal lesions on our sample of early-stage lung cancer patients and the fact that older people are more likely to determine CIAN, it is interesting to consider whether there is any relationship between the axonal type of neuropathy and lung disease in general. The possibility that a chronic obstructive pulmonary disease, based on presumed hypoxia, may lead to the axonal pathology of the peripheral nerves has been refuted so far 26 . In considering the CIAN etiology, special interest is currently focused on disturbed peripheral nerve vasa nervorum microcirculation, which is associated with the metabolic risk factors, but also the diseases of peripheral circulation of the atherosclerotic type 27 .…”

Section: Discussionmentioning

confidence: 99%

Clinical and electrophysiological features of peripheral neuropathy in older patients with lung carcinoma

Tomanovic-Vujadinovic

Jovanović

Ilić

et al. 2020

VOJNOSANIT PREGL

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Background/Aim. Peripheral nervous system affection in people with lung cancer is commonly associated with paraneoplastic neuropathy. However, clinical studies evaluating the frequency, clinical, and electrophysiological characteristics of peripheral neuropathies which are not related to onconeuronal antibodies, in this, on average, older population of patients, are very rare. The aim of this study was to define the frequency, as well as clinical and electrophysiological characteristics of idiopathic neuropathies in patients suffering from lung cancer in early stages of the diseases. Methods. Clinical and electrophysiological data of 105 elderly subjects (age 63.4 ± 7.8 years) suffering from lung carcinoma who underwent extensive neurological and electrophysiological evaluation (nerve conduction studies) between 2013-2018 were estimated. Exclusion criteria were "classical" paraneoplastic neurological syndromes with onconeuronal antibodies present, as well as patients with typical known causes of peripheral neuropathy (e.g. diabetes, alco-kom lečenja bolesnici podrgavaju nizu tretmana sa dodatnim rizikom od razvoj/pogoršanja neuropatija Ključne reči: pluća, neoplazme; plineuropatije; komorbiditet; stare osobe; elektrofiziologija.

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Chronic obstructive pulmonary disease is not a risk factor for polyneuropathy: A prospective controlled study

Cited by 7 publications

References 26 publications

Microangiopathy—A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review

Microangiopathy—A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review

The impact of COPD on polyneuropathy: results from the German COPD cohort COSYCONET

Clinical and electrophysiological features of peripheral neuropathy in older patients with lung carcinoma

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