Chronic Obstructive Pulmonary Disease in Can Tho: Clinical Characteristics and Features of Treatment by Clinical Phenotypes

Abstract

Background: phenotypic approach in the treatment of COPD is lacking in general medical facilities, despite the importance of this data. Objectives: The study aimed to identify divergences in features, pharmacologic regimens of COPD by clinical phenotypes in the real-life context of care units in Can Tho City that manage outpatients with chronic respiratory diseases. Materials and methods: a prospective cohort study was carried out. We enrolled 158 patients who met the sampling criteria for this study. Data collected include (1) biometric characteristics, (2) medical history, (3) characteristics of COPD (including: symptoms, chest radiograph, peripheral blood eosinophil count, pulmonary ventilation parameters, bronchodilator test, and pharmacological regimen). COPD were classified into three phenotypic groups according to the criteria of the 2017 Spanish guideline (GesEPOC) and were also categorized into four groups (ABCD) according to the 2019 GOLD guideline. Results: the clinical AE phenotype was predominant at 41.8%, whereas the NON-AE and ACO was 38.6% and 19.6%. According to the GOLD, classifying as group A, B, C, D is 19%, 34.8%, 10.1%, and 36.1%, respectively. Between the different phenotypic groups, there were a variety of variances in the eosinophil count of the peripheral blood, but there were no changes in some kinds of chest radiograph images. Response-to-bronchodilator-test rate was higher in the ACO phenotype than in the NON-AE and the AE phenotypes. All ACO patients who received LABA/ICS. The proportion of using LABA/ICS accounted for most NON-AE and AE patients. Conclusions: among clinical phenotypes, the AE phenotype accounted for the highest percentage. There were differences in the clinical characteristics among phenotypes. ICS using is popular among COPD patients.