Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis

Parris, Brielle; O’Farrell, Hannah E.; Fong, Kwun M.; Yang, Ian A.

doi:10.21037/jtd.2019.10.54

Cited by 97 publications

(81 citation statements)

References 196 publications

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“…Lung failure is a possible complication of both diseases and it often occurs after surgery (3) Lung cancer and COPD are often associated share the same initial pathogenesis (4) Lung cancer survival has reached partial improvements in the last few decades. Poor outcomes are linked to late clinical presentation, yet early diagnosis can be challenging as lung cancer symptoms are common and non-speci c.…”

Section: Resultsmentioning

confidence: 99%

Postoperative Severe Lung Failure and Functional Variations in Lung Cancer Patients with Different Extent of Resection: A Pilot Study .

Pezzuto

Marinucci

Pagliuca

et al. 2020

Preprint

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BACKGROUND Lung cancer is recognized to be the main cause of cancer death worldwide and it is closely associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). Only about 15% of patients affected by lung cancer are suitable for surgery and the clinical postoperative outcomes are variable.We aim to investigate the variables that affect post-surgery complications .METHODS A sample of 75 patients who underwent surgery for lung cancer was retrospectively studied about respiratory function and arterial gasanalysis .Data were collected before and after surgery. A subgroups comparative analysis was performed between group who underwent lobectomy vs group who underwent sub-lobar resection represented by either wedge or segmentectomy. Lung failure was categorized as severe for PaO2< 50 mmHg or non severe for PaO2 >50 mmHg.RESULTSThe overall data were: mean age 71.5, hospitalization time 7.8 days, pack-year 34, body mass index (BMI) 25.4, chronic obstructive pulmonary disease(COPD) assessment test (CAT) mean value was 16.5, forced expiratory one second volume (FEV1) at baseline 1.6 l corresponding to 73.6% of predicted.The mean age was 71.5, males/females rate 35/30The prevalent stage was IA and prevalent histotype was adenocarcinoma.Among the variables affecting lung failure development only the type of surgery along with presence of COPD showed a significant impact.Comparing the groups about the risk of severe lung failure development the treatment with lobectomy is associated with an increased risk compared with sub-lobar resection (p<0.0005). A CAT questionnaire > 10 was also associated with greater risk of lung failure with oxygen therapy need(p<0.04).The subgroups were comparable for age and pack-year , and for PaO2, FEV 1 and FVC at baseline. A significant difference was observed in terms of hospitalization time (p<0.03) that was longer in group of lobectomy and PaO2 15 days after surgery (p<0.03). The COPD percentage was higher in the group treated by lobectomy (p<0.01). The PaO2 level increased at 3 month check in patients treated with sub-lobar resection that was slightly increased compared with patients treated with lobar resection (p<0.04)post-surgery (p<0.04). The variations of the main functional parameters FEV1 and FVC in terms of a reduction the main functional parameters FEV1 and FVC were more evident in patients who underwent lobectomy compared with group treated with sub-lobar resection(p<0.001).CONCLUSIONSAll patients affected by lung cancer who undergo surgery report lung failure of different intensity depending on the type of surgery.COPD itself could influence the outcome, too. A greater negative variations of functional parameters after surgery is found in group who undergo lobectomy.

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Section: Resultsmentioning

confidence: 99%

Postoperative Severe Lung Failure and Functional Variations in Lung Cancer Patients with Different Extent of Resection: A Pilot Study .

Pezzuto

Marinucci

Pagliuca

et al. 2020

Preprint

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“…Smoking is the top modifiable risk factor for CVD, which is the leading cause of death in America, affecting millions each year [15]. Smoking also leads to chronic obstructive pulmonary disease (COPD) and a number of cancers, including lung cancer-the most deadly form of cancer in the USA [11,16]. The large disease burden associated with smoking contributes to a very substantial financial drain, costing the USA over $300 billion annually for direct medical costs and lost productivity.…”

Section: Tobacco Usementioning

confidence: 99%

Nicotine in Senescence and Atherosclerosis

Centner

Bhide²,

Salazar

2020

Cells

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Cigarette smoke is a known exacerbator of age-related pathologies, such as cardiovascular disease (CVD), atherosclerosis, and cellular aging (senescence). However, the role of nicotine and its major metabolite cotinine is yet to be elucidated. Considering the growing amount of nicotine-containing aerosol use in recent years, the role of nicotine is a relevant public health concern. A number of recent studies and health education sites have focused on nicotine aerosol-induced adverse lung function, and neglected cardiovascular (CV) impairments and diseases. A critical review of the present scientific literature leads to the hypothesis that nicotine mediates the effects of cigarette smoke in the CV system by increasing MAPK signaling, inflammation, and oxidative stress through NADPH oxidase 1 (Nox1), to induce vascular smooth muscle cell (VSMC) senescence. The accumulation of senescent VSMCs in the lesion cap is detrimental as it increases the pathogenesis of atherosclerosis by promoting an unstable plaque phenotype. Therefore, nicotine, and most likely its metabolite cotinine, adversely influence atherosclerosis.

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“…In particular, chronic obstructive pulmonary disease (COPD) is signi cantly associated with increasing morbidity and mortality after surgical resection for early-stage non-small cell lung cancer (NSCLC) [3][4][5]. COPD is a chronic in ammatory lung disease that causes air ow obstruction, which is also a major cause of morbidity and mortality [6]. Some common pathogenic factors and pathways contribute to lung cancer and COPD.…”

Section: Introductionmentioning

confidence: 99%

“…Some common pathogenic factors and pathways contribute to lung cancer and COPD. Tobacco smoking is the most common risk for lung cancer and COPD [6,7]. Besides, occupational exposure, physical activity, radiation, and air pollution are relevant pathogenic factors of lung cancer and COPD [7].…”

Section: Introductionmentioning

confidence: 99%

“…The effect of COPD on the prognosis of NSCLC patients has no de nite conclusion [6,9]. In clinical, treatment prefers chemotherapy to surgery in lung cancer patients complicated with COPD and COPD and some researchers considered that improved treatment should be adopted in lung cancer complicated with COPD compared with lung cancer patients [6]. However, the diagnostic biomarker for lung cancer complicated with COPD remain lacking.…”

Section: Introductionmentioning

confidence: 99%

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CircRNA Expression Profile in Lung Cancer Complicated with Chronic Obstructive Pulmonary Disease Patients

Wen¹,

Li²,

Shen³

et al. 2020

Preprint

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Background: Lung cancer complicated with chronic obstructive pulmonary disease (COPD) are major causes of mortality worldwide, and the incidence of lung cancer and COPD increasing significantly. Circular RNAs (circRNAs), have been reported to participate in various biological processes, whereas the role of circRNAs in lung cancer complicated with COPD remains unclear. We aims to identify differentially expressed circRNAs (DEcircRNAs) between lung cancer complicated with COPD and lung cancer without COPD. Method: The circRNAs expression profiles were identified using a high-throughput circRNA microarray in cancer adjacent tissues from 6 lung cancer without COPD patients and 8 lung cancer complicated with COPD patients. Bioinformatic analyses were conducted to identify the functions of DEcircRNAs. Result: A total of 115 up- and 128 down-regulated circRNAs were screened in lung cancer complicated with COPD patients compared with lung cancer without COPD patients. The myD88-dependent toll-like receptor signaling pathway and positive regulation of nitric oxide biosynthetic process ranked the top 2 enriched biological processes in Gene Ontology analysis. Signaling transduction and infectious diseases were the most significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways in both up- and down-regulated circRNAs. Compared with lung cancer without COPD, circRNAs are dysregulated in the adjacent tissues of lung cancer with COPD. Conclusion: The DEcircRNAs might act as potential targets for the diagnosis of lung cancer with COPD.

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Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis

Cited by 97 publications

References 196 publications

Postoperative Severe Lung Failure and Functional Variations in Lung Cancer Patients with Different Extent of Resection: A Pilot Study .

Postoperative Severe Lung Failure and Functional Variations in Lung Cancer Patients with Different Extent of Resection: A Pilot Study .

Nicotine in Senescence and Atherosclerosis

CircRNA Expression Profile in Lung Cancer Complicated with Chronic Obstructive Pulmonary Disease Patients

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