Chronic obstructive pulmonary disease as a risk factor for ventricular arrhythmias independent of left ventricular function

Konečný, Tomáš; Somers, Krishen; Park, Sun-Hee; John, Alan; Orban, Marek; Doshi, Rahul N.; Scanlon, Paul D.; Asirvatham, Samuel J.; Rihal, Charanjit S.; Brady, Peter A.

doi:10.1016/j.hrthm.2017.09.042

Cited by 31 publications

(30 citation statements)

References 29 publications

(36 reference statements)

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“…In a recent paper, Konecny et al [3] have highlighted the association of ventricular and supraventricular arrhythmic disturbances in COPD patients. Moreover, Men et al [4] also underlined the importance of the association of heart conduction abnormalities (such as sinus bradycardia and supraventricular arrhythmias) and severe-to-moderate sleep apnea.…”

Section: Discussionmentioning

confidence: 99%

A Case of Ventricular Fibrillation in a Frail Patient with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea Syndrome, and Electrolytic Disorder

Marchitto¹,

Mauti

Andreozzi

et al. 2018

Respiration

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Chronic obstructive pulmonary disease (COPD) is associated with an increased cardiovascular risk, although the pathophysiological mechanisms responsible for this interdependence are not completely known. For instance, the increased sympathetic activity may be implied. The severity of COPD correlates with various arrhythmic manifestations such as atrial fibrillation, atrial flutter, and either sustained or nonsustained ventricular tachycardia. COPD and obstructive sleep apnea syndrome may increase the overall cardiovascular risk, especially in elderly patients. Additionally, electrolytic disorders may precipitate cardiac rhythm disturbances and thus cause important arrhythmic consequences such as ventricular fibrillation, as reported in our clinical case. We discuss here the possible treatment of this association of pathological conditions on the basis of a single case we have successfully treated, and provide a brief review of the available literature regarding cardiovascular comorbidities in COPD patients.

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Section: Discussionmentioning

confidence: 99%

A Case of Ventricular Fibrillation in a Frail Patient with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea Syndrome, and Electrolytic Disorder

Marchitto¹,

Mauti

Andreozzi

et al. 2018

Respiration

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“…Theophylline increases the risk of arrhythmias, although it is rarely used in Australia and New Zealand for COPD . Finally, ventricular tachycardia is more frequent in COPD than in non‐COPD controls …”

Section: Copd and Cvd: Shared Pathophysiologymentioning

confidence: 99%

Coexisting chronic obstructive pulmonary disease and cardiovascular disease in clinical practice: a diagnostic and therapeutic challenge

Leong

MacDonald

et al. 2019

Medical Journal of Australia

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C hronic obstructive pulmonary disease (COPD) is the cardinal smoking-related respiratory illness. 1,2 Diagnosis requires exposure to noxious inhalants, respiratory symptoms, and spirometry demonstrating airflow obstruction, defined by a post-bronchodilator forced expiratory volume in one second (FEV 1 ) divided by forced vital capacity ratio < 0.70. 1,2 COPD is the fifth leading cause of disability-adjusted life-years worldwide, affecting about 14% of Australians above the age of 40 years. 2 COPD has a profound impact on the Australian hospital system. In 2015-16, it was the most common cause of potentially preventable hospitalisations related to chronic conditions in Australia; it was followed by heart failure. 3 In Australian general practice, both respiratory presentations and cardiovascular issues are common, so co-occurrence is frequent. 4 Cardiovascular disease (CVD) has compelling links to COPD. Individuals with COPD have a nearly 2.5-fold risk of CVD in comparison with controls. 5 Moreover, patients with comorbid COPD and CVD report more breathlessness and worse quality of life, are more frequently hospitalised and have higher mortality than those with COPD alone. 6 More than a quarter of patients with COPD will die from a cardiovascular event, and 40% of patients with COPD and a cardiovascular history will die following a cardiovascular event. 6Despite this, under-diagnosis of CVD in patients with COPD is frequent. For example, in patients with COPD and electrocardiographic evidence of myocardial infarction, less than one-third had been diagnosed with CVD. 7 COPD and CVD share risk factors and symptoms with significant overlap in clinical presentations. Determining the presence and contributions of the individual diseases can help clinicians prognosticate and manage this complex population.We searched PubMed for COPD and cardiovascular terms. We examined clinically relevant aspects of their relationship, diagnostic challenges and current and future therapeutic strategies. COPD and CVD: shared pathophysiologyDisease processes in COPD and CVD overlap, and salient clinical aspects are outlined below. Shared risk factorsPatients with COPD generally have multiple major risk factors for CVD. They have almost invariably smoked, and tend to be older, male and less physically active (Box 1). Hypertension is highly prevalent and present in up to 77% of some COPD cohorts. 1,5 However, these are insufficient to explain the excess CVD prevalence seen in COPD. 6 1

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“…p < 0,0001) und assoziiert war, sowie mit anhaltender ventrikulärer Tachykardie (sVT; 0,9 % vs. 1,6 %, p < 0,0001) und COPD ein signifikanter Prädiktor für Vorhofflimmern/Vorhofflattern und nsVT (p < 0,0001 bzw. p < 0,0001) nach Anpassung an Alter, Geschlecht, Tabakkonsum, Fettleibigkeit, Bluthochdruck, koronare Herzkrankheit, Herzinsuffizienz, Diabetes, Anämie, Krebs, chronische Nierenerkrankung und Medikamente zur Kontrolle von Herzfrequenz und Rhythmus ist [1].…”

Section: Arrhythmien Bei Patienten Mit Copdunclassified

Arrhythmien bei Lungenerkrankungen

et al. 2019

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ZUSAMMENFASSUNGPatienten mit Lungenerkrankungen haben häufig atriale und ventrikuläre Arrhythmien. Die Pathogenese dieser Arrhythmien ist komplex und kann viele Faktoren betreffen. Unter allen Lungenerkrankungen wird besonderes Augenmerk auf den Zusammenhang zwischen Arrhythmien bei Patienten mit COPD und obstruktivem Schlafapnoe-Syndrom gelegt. Dies sind die häufigsten Lungenerkrankungen, von denen angenommen wird, dass sie in Zukunft zunehmen.

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Chronic obstructive pulmonary disease as a risk factor for ventricular arrhythmias independent of left ventricular function

Cited by 31 publications

References 29 publications

A Case of Ventricular Fibrillation in a Frail Patient with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea Syndrome, and Electrolytic Disorder

A Case of Ventricular Fibrillation in a Frail Patient with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea Syndrome, and Electrolytic Disorder

Coexisting chronic obstructive pulmonary disease and cardiovascular disease in clinical practice: a diagnostic and therapeutic challenge

Arrhythmien bei Lungenerkrankungen

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