Chronic obstructive pulmonary disease and long-term mortality in elderly subjects with chronic heart failure

Abstract

Multivariate analysis indicates that CHF (Hazard risk = 1.67, 95% confidence interval 1.15-3.27, p < 0.031) and COPD (Hazard risk = 1.27, 95% confidence interval = 1.08-1.85, p < 0.042) were predictive of longterm mortality. When CHF and COPD simultaneously occurred, the risk dramatically increased up to 3.73 (95% confidence interval = 1.19-6.93, p < 0.001). Conclusions Long-term follow-up showed higher mortality among elderly subjects affected by CHF or COPD. Simultaneous presence of CHF and COPD significantly increased the risk of death. Therefore, the presence of COPD in CHF patients should be considered a relevant factor in predicting high risk of mortality.

Predictors of Mortality in COPD&nbsp;Exacerbation Cases Presenting to the Respiratory Intensive Care Unit

“…Testa et al found that patients with COPD and CHF had an increased risk of mortality compared with patients with either COPD or CHF alone. [27] The results of the present study were consistent with their study. There are some potential pathophysiological mechanisms that could explain the interaction between COPD and cardiovascular disease.…”

Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study

“…For instance, in a recent systematic review, reduction of left ventricular ejection fraction (LVEF) in patients with COPD was noted in 10–46% of patients depending on estimates [15]. Mortality rates are also higher in patients with concomitant HF and COPD [16].…”

Elderly with COPD: comoborbitidies and systemic consequences

“…A review of studies from different countries reports that 86 to 98% COPD patients have at least 1 other chronic disease with average number of comorbidities per individual ranging from 1.2 to 4.3 9 . Furthermore, the prevalence of comorbidities was found especially high in patients with severe COPD 10 . In addition, a recent meta-analysis highlights that Chronic obstructive pulmonary disease (COPD) represents a complex respiratory disorder characterized by persistent respiratory symptoms due to chronic airflow limitation caused by exposure to noxious particles/gases with an increased inflammatory response of the airways.…”

“…COPD is often accompanied by other concomitant chronic conditions that negatively impact prognosis and health status 6,7 . A large body of literature demonstrates that comorbidities are a widespread problem in COPD patients [8][9][10][11] . A review of studies from different countries reports that 86 to 98% COPD patients have at least 1 other chronic disease with average number of comorbidities per individual ranging from 1.2 to 4.3 9 .…”