Chronic obstructive bronchopulmonary disease

Filley, Giles F.; Beckwitt, Henry J.; Reeves, John Τ.; Mitchell, Roger S.

doi:10.1016/0002-9343(68)90234-9

Cited by 169 publications

(18 citation statements)

References 20 publications

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“…Repeated lung inflammations with episodes of lung hypoxia are an important cause of HPH in patients [23,24,25]. Inhibitors of mast cell degranulation may mitigate the development of HPH in these patients.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia

Baňasová¹,

Maxová

Hampl³

et al. 2008

Respiration

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Background: Chronic hypoxia induces lung vascular remodeling, which results in pulmonary hypertension. Vascular remodeling is associated with collagenolysis and activation of matrix metalloproteinases (MMPs). One of the possible sources of MMPs in hypoxic lung are mast cells. Objective: The role of lung mast cell collagenolytic activity in hypoxic pulmonary hypertension was tested by the inhibitor of mast cell degranulation disodium cromoglycate (DSCG). Methods: Rats were treated with DSCG in an early or later phase of isobaric hypoxia. Control groups were exposed to hypoxia only or to normoxia. Lung hemodynamics, muscularization and collagen metabolism in the walls of peripheral pulmonary vessels in the lungs were measured. Results: DSCG applied at an early phase of exposure to hypoxia reduced the development of pulmonary hypertension, inhibited muscularization in peripheral pulmonary arteries and decreased the amount of collagen cleavage fragments in prealveolar vessels. Conclusions: Mast cell degranulation plays a role in the initiation of hypoxic pulmonary vascular remodeling.

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Section: Discussionmentioning

confidence: 99%

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia

Baňasová¹,

Maxová

Hampl³

et al. 2008

Respiration

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“…Weight loss and skeletal muscle wasting, which are common in patients with COPD, can influence the course and the prognosis of COPD [17, 18]. Decreased caloric intake is often cited as a possible agent in the weight loss in COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Fructose 1,6-Diphosphate Administration in Malnourished Chronic Obstructive Pulmonary Disease Patients with Chronic Respiratory Failure

Marchesani¹,

Valerio

Dardes

et al. 2000

Respiration

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Background: Weight loss and skeletal muscle wasting are common in patients with chronic obstructive pulmonary disease (COPD) and can influence the course and the prognosis of COPD. Hypophosphatemia is a pathologic status often characterized by muscle weakness and is a frequent laboratory finding in these patients. Objective: The aim of the present study was to evaluate the effect of an organic phosphate (fructose 1,6-diphosphate, FDP) administration on respiratory performance in 45 malnourished COPD patients in stable clinical conditions. Methods: Physiologic evaluation including spirometry, maximal voluntary ventilation (MMV), elevated arm test, maximal mouth pressures (PImax and PEmax), respiratory response to CO₂, oxygen (PaO₂) and carbon dioxide (PaCO₂) arterial tension, a visual analogic scale (VAS) to measure dyspnea, and complete blood tests were done at the beginning and again at the end of the study. Results: After FDP administration, there was a significant increase in PImax (43.0 ± 18.3 cm H₂O before treatment vs. 49.8 ± 14.9 cm H₂O after treatment; p < 0.005). This did not occur in the placebo group (40.3 ± 17.4 cm H₂O before treatment vs. 42.6 ± 20.1 cm H₂O after treatment, nonsignificant). There was also a trend of VAS to decrease and of MVV to increase. Conclusions: These results show that FDP administration may be useful in the management of malnourished COPD patients, especially in increasing their respiratory muscle strength.

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“…[8][9][10][11][12] took part in the second phase of the investigation. Dyspnea was similarly provoked by walking on the treadmill.…”

Section: Methodsmentioning

confidence: 99%

“…Pulmonary hypertension could have occurred in these patients as a consequence of the relatively severe exercise, the marked rise in pulmonary artery pressure (8) being brought about by a combination of hypoxia and hyperacidemia (9,10). Reports in the literature have suggested that increased pulmonary artery pressure could cause pulmonary interstitial edema (11,12).…”

Section: Methodsmentioning

confidence: 99%

Alterations in the mechanical properties of the lung during dyspnea in chronic obstructive pulmonary disease

Suero¹,

Woolf²

1970

J. Clin. Invest.

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A B S T R A C T The mechanical properties of the lungs in seven patients with chronic obstructive pulmonary disease (COPD) were measured before and during dyspnea on exertion, as well as when relief with added oxygen was obtained. Mean pulmonary dynamic compliance was 0.091 liters/cm of H20 before dyspnea, 0.057 during dyspnea, and 0.101 liters/cm H20 during relief. During dyspnea there was an increase in the total respiratory work (both elastic and nonelastic work) and this fell during relief with oxygen. Nonelastic resistance and respiratory rate were not significantly different during the three periods. In five similar patients a progressive increase in the instantaneous rate of change of transpulmonary pressure (dP/dt) was observed during exercise and this was markedly increased during dyspnea. These changes in dP/dt during exercise could explain the observed fall of pulmonary dynamic compliance. INTRODUCTIONDyspnea on exertion is a major cause of disability in patients with chronic obstructive pulmonary disease (COPD). Although many pulmonary function abnormalities have been recorded in this disease, there is little information (1) concerning the alterations in the mechanics of breathing when the patients are actually dyspneic. The purpose of this communication is to report the changes in the mechanical properties of the lungs in COPD patients walking on a treadmill. Measurements were made before the patient became dyspneic, during dyspnea, and also when relief was obtained by breathing an added oxygen-inspired gas mixture while walking continued.

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Chronic obstructive bronchopulmonary disease

Cited by 169 publications

References 20 publications

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia

Effect of Intravenous Fructose 1,6-Diphosphate Administration in Malnourished Chronic Obstructive Pulmonary Disease Patients with Chronic Respiratory Failure

Alterations in the mechanical properties of the lung during dyspnea in chronic obstructive pulmonary disease

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