Chronic Non-bacterial Osteomyelitis: A Review

Buch-Larsen, Kristian; Thuesen, Anne Cathrine Baun; Brøns, Charlotte; Schwarz, Peter

doi:10.1007/s00223-018-0495-0

Cited by 81 publications

(106 citation statements)

References 72 publications

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“…Fatty acids are also involved in non‐typical skeletal diseases such as osteomyelitis, a bone inflammatory process initiated by infection of pyogenic organisms that predominantly occurs in long bones of children, and in hips, feet, jaws and spine of adults . This disease is characterized by severe damage to bone tissue and bone marrow, and probably accompanied by high morbidity and mortality . Accumulating evidence has shown that ω‐3 LCPUFAs could effectively combat microbial pathogenesis in osteomyelitis .…”

Section: Implications Of Fatty Acids In Bone Diseasesmentioning

confidence: 99%

“…[98][99][100] This disease is characterized by severe damage to bone tissue and bone marrow, and probably accompanied by high morbidity and mortality. 100 Accumulating evidence has shown that ω-3 LCPUFAs could effectively combat microbial pathogenesis in osteomyelitis. [101][102][103] Furthermore, combination of vancomycin and ω-3 LCPUFAs has been suggested to be a reliable therapeutic strategy against S aureus-induced osteomyelitis, with a mechanism involving inflammation alleviation by reducing TNF-α and interleukin 6 (IL-6) levels as well as antioxidant activity by decreasing SOD activity.…”

Section: Other Bone Disordersmentioning

confidence: 99%

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Therapeutic potentials and modulatory mechanisms of fatty acids in bone

et al. 2019

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Bone metabolism is a lifelong process that includes bone formation and resorption. Osteoblasts and osteoclasts are the predominant cell types associated with bone metabolism, which is facilitated by other cells such as bone marrow mesenchymal stem cells (BMMSCs), osteocytes and chondrocytes. As an important component in our daily diet, fatty acids are mainly categorized as long‐chain fatty acids including polyunsaturated fatty acids (LCPUFAs), monounsaturated fatty acids (LCMUFAs), saturated fatty acids (LCSFAs), medium‐/short‐chain fatty acids (MCFAs/SCFAs) as well as their metabolites. Fatty acids are closely associated with bone metabolism and associated bone disorders. In this review, we summarized the important roles and potential therapeutic implications of fatty acids in multiple bone disorders, reviewed the diverse range of critical effects displayed by fatty acids on bone metabolism, and elucidated their modulatory roles and mechanisms on specific bone cell types. The evidence supporting close implications of fatty acids in bone metabolism and disorders suggests fatty acids as potential therapeutic and nutritional agents for the treatment and prevention of metabolic bone diseases.

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Section: Implications Of Fatty Acids In Bone Diseasesmentioning

confidence: 99%

Section: Other Bone Disordersmentioning

confidence: 99%

Therapeutic potentials and modulatory mechanisms of fatty acids in bone

et al. 2019

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“…This brings pharmacological therapy for CNO into focus, which can also be regarded as consensusable today against the background of other reviews [7,20]. The literature also contains a large number of case reports and case series on conservative therapy for CNO.…”

Section: Pharmacological Therapymentioning

confidence: 99%

“…Patients with CNO show an underproduction of anti-inflammatory cytokines (interleukin-10) and overproduction of proinflammatory cytokines (tumor necrosis factor-α (TNFα) and interleukin-1). Due to the spontaneous hyperproduction of proinflammatory cytokines without autoimmunity features, CNO is classified as an autoinflammatory disease, thus falling into the rheumatic group of diseases [7][8][9][10][11][12][13][14]. The oral and maxillofacial surgery literature also discusses further factors as etiology of CNO.…”

Section: Introductionmentioning

confidence: 99%

Response of Different Treatment Protocols to Treat Chronic Non-Bacterial Osteomyelitis (CNO) of the Mandible in Adult Patients: A Systematic Review

Timme

Bohner

Huss

et al. 2020

IJERPH

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(1) Background: Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone disease of finally unknown etiology, which can occur alone or related with syndromes (chronic recurrent multifocal osteomyelitis—CRMO; synovitis, acne, pustulosis, hyperostosis and osteitis syndrome—SAPHO). The involvement of the mandible is rather rare. (2) Methods: We carried out a systematic literature search on CNO with mandibular involvement, according to the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” (PRISMA) guidelines, considering the different synonyms for CNO, with a special focus on therapy. (3) Results: Finally, only four studies could be included. A total of 36 patients were treated in these studies—therefore, at most, only tendencies could be identified. The therapy in the included works was inconsistent. Various therapies could alleviate the symptoms of the disease. A complete remission could only rarely be observed and is also to be viewed against the background of the fluctuating character of the disease. The success of one-off interventions is unlikely overall, and the need for long-term therapies seems to be indicated. Non-steroidal anti-inflammatory drugs (NSAIDs) were not part of any effective therapy. Surgical therapy should not be the first choice. (4) Conclusions: In summary, no evidence-based therapy recommendation can be given today. For the future, systematic clinical trials on therapy for CNO are desirable.

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“…In addition, the authors provide a fascinating insight into the management of these disorders based on their extensive personal experience. There then follows a comprehensive review by Buch and colleagues of the enigmatic syndrome of chronic non-bacterial osteomyelitis (CNO) [10]. This rare disorder presents with bone pain and deformity secondary to focal abnormalities of increased bone turnover.…”

mentioning

confidence: 99%