Chronic non-allergic rhinitis with neutrophils is associated with higher acid exposure time: A pH-impedance monitoring study

Mandolesi, Daniele; Schiavon, Patrizia; Ioannou, Alexandros; Mancini, Milena; Cimatti, M.; Azzaroli, Francesco; Liverani, Elisa; Pierantoni, Chiara; Pirodda, Antonio; Giorgio, Roberto De; Bazzoli, Franco; Torresan, F.

doi:10.1016/j.dld.2019.11.008

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The incidence of this rhinopathy has increased in recent years, probably due to industrialization and increased smoking habits, since the majority of patients suffering from this form of rhinitis are industrial workers, smokers or people living in industrialized areas [ 19 ]. Gastroesophageal reflux is one of the causes of NARNE, as exhaling hydrochloric acid and its contact with the nasal mucosa attracts neutrophils, first response inflammatory cells, to the mucosal level [ 20 ]. The permanence of these cells and the release of chemical mediators, including neutrophilic elastase, leads to the formation of free radicals and to mucosal damage, which result in "vasomotor" symptoms, such as sneezing, nasal congestion and seromucous rhinorrhea [ 21 ].…”

Section: Vasomotor Rhinitismentioning

confidence: 99%

General classification of rhinopaties: the need for standardization according to etiology and nasal cytology

Gelardi,

Fiore,

Giancaspro

et al. 2023

Eur Arch Otorhinolaryngol

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Background Rhinitis is as an inflammation of the nasal mucosa, characterized by high prevalence, widespread morbidity, and a significant financial burden on health care systems. Nevertheless, it is often considered as no more than a mere annoyance. This point of view has progressively led to underestimate and trivialize the disease. Therefore, there are numerous, mostly overlapping classifications of rhinopaties, but clear and standardized guidelines for diagnosis and treatment are still lacking. In the context of Precision Medicine, the development of a classification system focused on the endotypes of rhinitis to be widely adopted appears of utmost importance, also by virtue of study of the nasal immunophlogosis that, thanks to nasal cytology (NC), has recently allowed to better define the different forms of rhinitis, giving a new nosological dignity to several rhinopaties. Aim We aimed to summarize the current knowledge regarding rhinitis and to propose a systematic classification of rhinitis, based on both etiology and cytological findings

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Section: Vasomotor Rhinitismentioning

confidence: 99%

General classification of rhinopaties: the need for standardization according to etiology and nasal cytology

Gelardi,

Fiore,

Giancaspro

et al. 2023

Eur Arch Otorhinolaryngol

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“…In a population-based Brazilian survey the diagnosis of gastritis/ulcer/gastroesophageal reflux was associated with higher prevalence of rhinosinusitis symptoms in multivariable analysis [18]. An Italian study on a small series undergoing both nasal cytology and esophageal manometry and 24-h pH-impedance monitoring showed that NAR with neutrophils strongly correlated with higher acid exposure time and refluxes number [19]. On the basis of this accumulating evidence, the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis [20] assigned grade B evidence to support the association between chronic rhinosinusitis and GERD, although causation could not be clearly demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders

et al. 2021

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Background Gastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated. Aims To evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis. Methods We investigated 2887 subjects aged 20–84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Subjects were asked if they had doctor-diagnosed “gastritis or stomach ulcer (confirmed by gastroscopy)” or “gastroesophageal reflux disease, hiatal hernia or esophagitis”. The association between NAR/AR/sinusitis and either gastritis or GERD was evaluated through relative risk ratios (RRR) by multinomial logistic regression. Results The prevalence of gastritis/GERD increased from subjects without nasal disturbances (22.8% = 323/1414) to subjects with AR (25.8% = 152/590) and further to subjects with NAR (36.7% = 69/188) or sinusitis (39.9% = 276/691). When adjusting for centre, sex, age, education level, BMI, smoking habits and alcohol intake, the combination of gastritis and GERD was associated with a four-fold increase in the risk of NAR (RRR = 3.80, 95% CI 2.56–5.62) and sinusitis (RRR = 3.70, 2.62–5.23) with respect to controls, and with a much smaller increase in the risk of AR (RRR = 1.79, 1.37–2.35).. Conclusion The study confirmed the association between gastritis/GERD and nasal disturbances, which is stronger for NAR and sinusitis than for AR.

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Chronic non-allergic rhinitis with neutrophils is associated with higher acid exposure time: A pH-impedance monitoring study

Cited by 2 publications

References 32 publications

General classification of rhinopaties: the need for standardization according to etiology and nasal cytology

General classification of rhinopaties: the need for standardization according to etiology and nasal cytology

Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders

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