Chronic nicotine impairs the angiogenic capacity of human induced pluripotent stem cell-derived endothelial cells in a murine model of peripheral arterial disease

Chan, Alex H.P.; Hu, Caroline; Chiang, Gladys C.F.; Ekweume, Chisomaga; Huang, Ngan F.

doi:10.1016/j.jvssci.2023.100115

Cited by 1 publication

(1 citation statement)

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“…For example, emerging research in preclinical models suggests that lifestyle choices such as tobacco exposure can negatively affect the efficacy of stem cell therapy for treatment of PAD. 110,111 Therefore, autologous stem cells from some patients may need preconditioning to reverse or reprogram the cells into a functional state before transplantation. In this regard, biomaterials can become a tool to modulate cellular function.…”

Section: Current Challenges and Future Directionsmentioning

confidence: 99%

Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease

Huang,

Stern,

Oropeza

et al. 2024

ATVB

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Peripheral artery disease is an atherosclerotic disease associated with limb ischemia that necessitates limb amputation in severe cases. Cell therapies comprised of adult mononuclear or stromal cells have been clinically tested and show moderate benefits. Bioengineering strategies can be applied to modify cell behavior and function in a controllable fashion. Using mechanically tunable or spatially controllable biomaterials, we highlight examples in which biomaterials can increase the survival and function of the transplanted cells to improve their revascularization efficacy in preclinical models. Biomaterials can be used in conjunction with soluble factors or genetic approaches to further modulate the behavior of transplanted cells and the locally implanted tissue environment in vivo. We critically assess the advances in bioengineering strategies such as 3-dimensional bioprinting and immunomodulatory biomaterials that can be applied to the treatment of peripheral artery disease and then discuss the current challenges and future directions in the implementation of bioengineering strategies.

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Section: Current Challenges and Future Directionsmentioning

confidence: 99%