Chronic Nicotine Exposure Reduces Antioxidant Function of Simvastatin in Renal Proximal Tubule Cells

Abstract

Antioxidant efficiency of simvastatin might be significantly lessened in smokers/E-cigarette users.

Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease

“…Conversely, in vitro and in vivo investigations describe the toxicity of nicotine in renal cells, mainly by triggering oxidative stress and inflammation. These effects impair the viability and function of renal tubular and endothelial cells, alter renal hemodynamics, and compromise overall kidney function [ 109 , 110 ].…”

“…Directly or indirectly, these xenobiotics can impair glucose metabolism by affecting β islet cell homeostasis [ 85 , 86 , 90 ] and mitochondrial function in an ROS-dependent manner, culminating in insulin resistance and Diabetes Mellitus type II onset [ 95 , 100 , 135 ]. Finally, the kidneys are affected by the systemic inflammatory response, increased blood pressure, and higher levels of ROS, which increase mesangial cell proliferation, activate programmed cell death pathways on tubular cells, and impair mitochondrial function [ 109 , 110 , 111 , 112 , 113 , 114 , 115 , 135 , 136 , 137 ]. Once the kidneys are responsible for filtration, these xenobiotics accumulate on renal structures and cause inflammation and oxidative stress.…”