Chronic Neutropenia

Dale, David C.; GUERRYIV, DuPONT; WEWERKA, JOHN R.; Bull, Joan M C; Chusid, Michael J.

doi:10.1097/00005792-197903000-00002

Cited by 166 publications

(103 citation statements)

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“…Regardless of whether his disorder is classified as atypical cyclic neutropenia (Wright et al, 1981) or chronic idiopathic neutropenia (Dale et al, 1979), he was a candidate for treatment with filgrastim because of chronic infectious symptomatology.…”

Section: Discussionmentioning

confidence: 99%

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Successful treatment of chronic severe neutropenia with weekly recombinant granulcyte‐colony stimulating factor

Fine¹,

Byrd²,

Stone

1997

Br J Haematol

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Summary.Daily treatment for symptomatic chronic neutropenia with recombinant granulocyte-colony stimulating factor (rhG-CSF) filgrastim is costly and sometimes causes neutrophillia. We report the use of weekly filgrastim in a 40-year-old man with life-long symptomatic neutropenia. Baseline neutrophil counts were < 1 × 10 9 /l 60% of the time, and fell below 0 : 5 × 10 9 /l for 7 d periods every 22 d. Following 1 year of weekly filgrastim treatment, the absolute neutrophil count was maintained > 1 × 10 9 /l (averaging 2 × 10 9 /l) and the frequency and severity of symptoms were reduced by 85%. Therefore the benefits of filgrastim for the treatment of at least one form of chronic severe neutropenia can be derived from weekly rather than daily doses.

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Section: Discussionmentioning

confidence: 99%

“…Symptomatic chronic severe neutropenia causes recurrent pyogenic infections with the potential for significant morbidity (Lipton, 1969;Pincus et al, 1976;Dale et al, 1979;Wright et al, 1981;Jonsson & Buchanan, 1991). Until recently, treatment of this disorder mainly included antibiotics, either prophylactically or for documented infections.…”

mentioning

confidence: 99%

Successful treatment of chronic severe neutropenia with weekly recombinant granulcyte‐colony stimulating factor

Fine¹,

Byrd²,

Stone

1997

Br J Haematol

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show abstract

“…The herein presented clinical and laboratory findings are unusual in that they do not reflect the picture of any of the three types of the introduced chronic neutropenias [1,[5][6][7]10]. Homozygous base exchanges were found in the patient's G-CSF gene when compared to the originally described sequence [21,22].…”

mentioning

confidence: 84%

“…Three types of severe chronic neutropenia (SCN) are known: the congenital, the cyclic, and the idiopathic form [1][2][3][4][5][6][7]. All three types can be effectively treated with long-term G-CSF [8].…”

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confidence: 99%

Anti‐G presenting as a blood transfusion error

et al. 2009

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“…Functional tests on patient's neutrophils did not reveal any abnormality. The herein presented clinical and laboratory findings are unusual in that they do not reflect the picture of any of the three types of the introduced chronic neutropenias [1,[5][6][7]10]. Homozygous base exchanges were found in the patient's G-CSF gene when compared to the originally described sequence [21,22].…”

mentioning

confidence: 84%