Chronic Neurological Disease in Two Manganese Steel Workers

Whitlock, Coleman M.; Amuso, S. J.; Bittenbender, J. B.

doi:10.1080/00028896609342453

Cited by 49 publications

(16 citation statements)

References 3 publications

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“…At higher Mn-exposure levels, Flinn et al (1941) observed leucopenia in 7 of 11 intoxicated workers, whereas Rodier (1955) noticed a relative increase in lymphocytes and a decrease in polymorphonuclear leukocytes. Polymorphonuclear leukocytosis was reported in two Mn steel workers with chronic neurological disease (Whitlock et al, 1966).…”

Section: Methodsmentioning

confidence: 99%

Motor Function, Olfactory Threshold, and Hematological Indices in Manganese-Exposed Ferroalloy Workers

Lucchini

Bergamaschi

Smargiassi

et al. 1997

Environmental Research

105

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Section: Methodsmentioning

confidence: 99%

Motor Function, Olfactory Threshold, and Hematological Indices in Manganese-Exposed Ferroalloy Workers

Lucchini

Bergamaschi

Smargiassi

et al. 1997

Environmental Research

105

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“…The nearby presence of industrial point sources of manganiferous emissions can produce pronounced deviations from normal background levels, the main industries implicated being ferroalloy factories, steel mills, ore crushing plants, welding activities, and dry cell battery manufacture. Manganiferous pollution associated with Mn ferroalloy plants can be especially polluting, with many early studies demonstrating atmospheric concentrations of Mn measurable in μg/m 3 or even mg/m 3 within or near such factories (Sabnis et al 1966;Whitlock et al 1966;Itakura and Tajima 1972;Suzuki et al 1973;Saric et al 1977;IPCS 1981;WHO 1987;IPCS 1999). Published data on atmospheric Mn levels around industrial point sources have tended to focus on the areas adjacent to the factories, and have rarely paid attention to the wider issue of raised background levels over a broader urban area.…”

Section: Introductionmentioning

confidence: 97%

Manganese in the urban atmosphere: identifying anomalous concentrations and sources

Moreno

Pandolfi

Querol

et al. 2010

Environ Sci Pollut Res

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We demonstrate the anomalous nature of such concentrations by comparing them with >2,500 PM(10) chemical analyses of ambient PM(10) from other sites in Spain which show how current background Mn levels in urban air typically average only 10 ng/m(3), rising to 20-25 ng/m(3) in city traffic sites. Daily levels of atmospheric Mn PM(10) only rarely exceed 50 ng/m(3), usually during desert dust intrusions which, in extreme cases (such as Canary Islands "calima" events from Africa) can produce Mn concentrations of 100-125 ng/m(3).

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“…34 Those exposed to manganese while working in the steel industry also may develop progressive parkinsonism. [35][36][37] Levodopa responsiveness in these parkinsonian subjects is transient and not associated with motor fluctuations. [39][40][41] Although our patients differ from the classic scenario of manganese exposures, this does not necessarily disprove the association.…”

mentioning

confidence: 99%

“…[34][35][36][37][38] The syndrome, best characterized in Moroccan manganese miners, includes progressive parkinsonism, dystonia, and neuropsychiatric symptoms. 34 Those exposed to manganese while working in the steel industry also may develop progressive parkinsonism.…”

mentioning

confidence: 99%

Welding-related parkinsonism

Racette¹,

McGee‐Minnich²,

Moerlein³

et al. 2001

Neurology

286

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Article abstract-Objective: To determine whether welding-related parkinsonism differs from idiopathic PD. Background: Welding is considered a cause of parkinsonism, but little information is available about the clinical features exhibited by patients or whether this is a distinct disorder. Methods: The authors performed a case-control study that compared the clinical features of 15 career welders, who were ascertained through an academic movement disorders center and compared to two control groups with idiopathic PD. One control group was ascertained sequentially to compare the frequency of clinical features, and the second control group was sex-and age-matched to compare the frequency of motor fluctuations. Results: Welders were exposed to a mean of 47,144 welding hours. Welders had a younger age at onset (46 years) of PD compared with sequentially ascertained controls (63 years; p Ͻ 0.0001). There was no difference in frequency of tremor, bradykinesia, rigidity, asymmetric onset, postural instability, family history, clinical depression, dementia, or drug-induced psychosis between the welders and the two control groups. All treated welders responded to levodopa. Motor fluctuations and dyskinesias occurred at a similar frequency in welders and the two control groups. PET with 6-[18 F]fluorodopa obtained in two of the welders showed findings typical of idiopathic PD, with greatest loss in posterior putamen. Conclusions: Parkinsonism in welders is distinguished clinically only by age at onset, suggesting welding may be a risk factor for PD. These preliminary data cannot exclude a genetic contribution to susceptibility in these exposed individuals.

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Chronic Neurological Disease in Two Manganese Steel Workers

Cited by 49 publications

References 3 publications

Motor Function, Olfactory Threshold, and Hematological Indices in Manganese-Exposed Ferroalloy Workers

Motor Function, Olfactory Threshold, and Hematological Indices in Manganese-Exposed Ferroalloy Workers

Manganese in the urban atmosphere: identifying anomalous concentrations and sources

Welding-related parkinsonism

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