Chronic Neurologic Sequelae to Cholinesterase Inhibition among Agricultural Pesticide Applicators

Ames, Richard; Steenland, Kyle; Jenkins, B S; Chrislip, David W.; Russo, John

doi:10.1080/00039896.1995.9935980

Cited by 96 publications

(74 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of these studies did not exclude individuals with a history of pesticide poisoning. Several studies in which such individuals were excluded found no relationship of chronic exposure to neurobehavioral performance or nerve conduction velocity (Ames et al 1995;Engel et al 1998;Fiedler et al 1997), but other studies of nonpoisoned individuals have found associations (Stephens et al 1995;van Wendel de Joode et al 2001). We found that farm work was related to worse performance even after excluding 19 individuals who had experienced acute toxic reactions to pesticides.…”

Section: Discussioncontrasting

confidence: 53%

Neurobehavioral performance and work experience in Florida farmworkers.

Kamel

Rowland

Park

et al. 2003

Environ Health Perspect

View full text Add to dashboard Cite

Farmworkers experience many work-related hazards, including exposure to neurotoxicants. We compared neurobehavioral performance of 288 farmworkers in central Florida who had done farm work for at least 1 month with 51 controls who had not. Most of the farmworkers had worked in one or more of three types of agriculture: ornamental ferns, nurseries, or citrus fruit. We collected information on farm work history in a structured interview and evaluated neurobehavioral performance using a battery of eight tests. Analyses were adjusted for established confounders including age, sex, education, and acculturation. Ever having done farm work was associated with poor performance on four tests--digit span [odds ratio (OR) = 1.90; 95% confidence interval (CI), 1.02-3.53], tapping (coefficient = 4.13; 95% CI, 0.00-8.27), Santa Ana test (coefficient = 1.34; 95% CI, 0.29-2.39), and postural sway (coefficient = 4.74; 95% CI, -2.20 to 11.7)--but had little effect on four others: symbol digit latency, vibrotactile threshold, visual contrast sensitivity, and grip strength. Associations with farm work were similar in magnitude to associations with personal characteristics such as age and sex. Longer duration of farm work was associated with worse performance. Associations with fern work were more consistent than associations with nursery or citrus work. Deficits related to the duration of work experience were seen in former as well as current farmworkers, and decreased performance was related to chronic exposure even in the absence of a history of pesticide poisoning. We conclude that long-term experience of farm work is associated with measurable deficits in cognitive and psychomotor function.

show abstract

Section: Discussioncontrasting

confidence: 53%

Neurobehavioral performance and work experience in Florida farmworkers.

Kamel

Rowland

Park

et al. 2003

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…Most studies found deficits on one or several tests of cognitive function, but not on other tests, and there was not full agreement among studies in which tests were affected. Further, no deficits in cognitive function were found in other studies of OP exposure (10,76,108,269).…”

Section: Chronic Low-level Exposurementioning

confidence: 55%

Health Effects of Chronic Pesticide Exposure: Cancer and Neurotoxicity

Alavanja

Hoppin

Kamel

2004

Annu. Rev. Public Health

638

369

View full text Add to dashboard Cite

health s Abstract Pesticides are widely used in agricultural and other settings, resulting in continuing human exposure. Epidemiologic studies indicate that, despite premarket animal testing, current exposures are associated with risks to human health. In this review, we describe the routes of pesticide exposures occurring today, and summarize and evaluate the epidemiologic studies of pesticide-related carcinogenicity and neurotoxicity in adults. Better understanding of the patterns of exposure, the underlying variability within the human population, and the links between the animal toxicology data and human health effects will improve the evaluation of the risks to human health posed by pesticides. Improving epidemiology studies and integrating this information with toxicology data will allow the human health risks of pesticide exposure to be more accurately judged by public health policy makers.

show abstract

“…It is suggested in the present study that Delsen may exert their effects by inhibiting cholinesterase enzymes, as in Delsen users median SCV was significantly correlated with serum cholinesterase activities, which was lower than the activities in controls. By contrast, it has been observed that slowing of peripheral nerve conduction velocities were not related to cholinesterase inhibition in organophosphate or carbamate users 41) .…”

Section: Discussionmentioning

confidence: 90%

Effects of Pesticides on the Peripheral and Central Nervous System in Tobacco Farmers in Malaysia: Studies on Peripheral Nerve Conduction, Brain-Evoked Potentials and Computerized Posturography

et al. 2005

View full text Add to dashboard Cite

We examined the effects of pesticides on the central and peripheral nervous system in the setting of a tobacco farm at a developing country. Maximal motor and sensory nerve conduction velocities (MCV and SCV, respectively) in the median, sural and tibial nerves, postural sway, and brain-evoked potentials (auditory event-related and visual-evoked potentials) were measured in 80 male tobacco farmers and age-and sex-matched 40 controls in Kelantan, Malaysia. Median SCV (finger-wrist) in farmers using Delsen (mancozeb, dithiocarbamate fungicide), who showed significant decrease of serum cholinesterase activities, were significantly lower compared with the controls. Sural SCV in farmers using Fastac (α α α α α-cypermethrin, pyrethroid insecticide) and median MCV (elbowwrist) in farmers using Tamex (butralin, dinitroaniline herbicide) were significantly slowed compared with their respective controls. In Delsen (mancozeb, dithiocarbamate) users, the power of postural sway of 0-1 Hz was significantly larger than that in the controls both in the anterior-posterior direction with eyes open and in the right-left direction with eyes closed. The former type of sway was also significantly increased in Tamaron (methamidophos, organophosphorus insecticide) users. In conclusion, nerve conduction velocities and postural sway seem to be sensitive indicators of the effects of pesticides on the central and peripheral nervous system.

show abstract

Chronic Neurologic Sequelae to Cholinesterase Inhibition among Agricultural Pesticide Applicators

Cited by 96 publications

References 12 publications

Neurobehavioral performance and work experience in Florida farmworkers.

Neurobehavioral performance and work experience in Florida farmworkers.

Health Effects of Chronic Pesticide Exposure: Cancer and Neurotoxicity

Effects of Pesticides on the Peripheral and Central Nervous System in Tobacco Farmers in Malaysia: Studies on Peripheral Nerve Conduction, Brain-Evoked Potentials and Computerized Posturography

Contact Info

Product

Resources

About