Chronic Nerve Compression Accelerates the Progression of Diabetic Peripheral Neuropathy in a Rat Model: A Study of Gene Expression Profiling

Tu, Yiji; Chen, Zenggan; Hu, Junda; Ding, Zuoyou; Lineaweaver, William C.; Dellon, A. Lee; Zhang, Feng

doi:10.1055/s-0038-1642023

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…The double crush hypothesis states that a diabetic nerve is more susceptible to compression than a nondiabetic nerve (7). Another study has reported that chronic nerve compression could accelerate the progression of diabetic neuropathy in the rat model (22). Therefore, diabetic nerve entrapment is a complicated process in which 2 factors of diabetic neuropathy and nerve entrapment interact with each other.…”

Section: Discussionmentioning

confidence: 99%

A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats

Zhu

Liu

et al. 2020

Ann Transl Med

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Background: Our study investigates the feasibility of using quantitative evaluation for nerve entrapment visualization by shear wave elastography (SWE) in diabetic rats.Methods: A total of 24 male Sprague-Dawley (SD) rats were included in this study. Before injection of streptozotocin (STZ), the experimental groups were assigned as the diabetic nerve compression (DNC) group (DNC, n=18) and the control group (CON, n=6). The DNC model was created by wrapping a silicone tube around the nerve, and then the DNC group was divided into the DNC 2-week (DNC2W, n=6), 4-week (DNC4W, n=6), and 8-week (DNC8W, n=6) groups according to the different duration time of sciatic nerve compression. The nerve stiffness was detected by SWE. Meanwhile, motor nerve conduction velocity (MNCV) was detected. These 2 indicators and histology of sciatic nerves were compared across the different groups.Results: The stiffness of the nerve depicted by SWE at the compression site increased markedly along with the duration time of compression (P<0.01). The MNCV decreased along with the duration time of nerve compression (P<0.05). The nerve stiffness depicted by SWE was negatively correlated with MNCV (r=−0.926; P<0.01). Myelinated fiber density significantly decreased as the duration time of nerve compression increased (P<0.01). Some differences were found between DNC4W and DNC8W groups, and CON and DNC2W groups (P<0.05) in average axon diameter, myelin sheath thickness, and g ratio. Conclusions:The increased values of SWE, along with the increased duration of nerve compression, could reflect the severity of nerve entrapment in diabetic rats. Therefore, SWE may be used as a noninvasive and effective method to quantitatively evaluate the severity of diabetic nerve entrapment.

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Section: Discussionmentioning

confidence: 99%

A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats

Zhu

Liu

et al. 2020

Ann Transl Med

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“…While processes related to lipid and glucose metabolism, response to insulin, and apoptosis regulation were inhibited after diabetes induction, chronic nerve compression further enhanced these inhibitions." 42 Thus the application of ND to treat DSPN has some scientific basis and support.…”

Section: Other Nerve Decompression Studiesmentioning

confidence: 99%

Acute Improvement in Intraoperative EMG During Common Fibular Nerve Decompression in Patients with Symptomatic Diabetic Sensorimotor Peripheral Neuropathy: EMG and Clinical Attribute Interrelations

Yamasaki¹,

Nickerson²,

Anderson³

2020

J Neurol Surg A Cent Eur Neurosurg

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Study Aims Electromyographic (EMG) recordings of the fibularis longus and tibialis anterior muscles were performed intraoperatively during nerve decompression (ND) of the common fibular nerve (CFN) in patients with symptomatic diabetic sensorimotor peripheral neuropathy. Patient demographics and clinical attributes were compared against changes in EMG after ND and analyzed for possible correlations. Methods Intraoperative changes in CFN EMG were analyzed for correlations against sex, age, body mass index (BMI), hemoglobin A1c (A1c), and type and duration of diabetes. Results Statistically significant changes were found between EMG changes and patient attributes, but no individual correlations were established. Significant EMG improvement was observed for both men and women (p < 0.0001 and p < 0.05, respectively), age groups (4th decade: p < 0.05; 5th decade: p < 0.05; 6th decade: p < 0.01; 7th decade: p < 0.005), diabetes duration (0–9 years: p = 0.002; 10–19 years: p = 0.002; 20–29 years: p = 0.03), and for type 1 and 2 diabetes (type 1: p < 0.005; type 2: p < 0.001). EMG improvement was greater in patients with the highest BMI levels (30–34.9: p = 0.014; 35–39.9: p = 0.013; > 39.9: p = 0.043), and highest A1c levels (> 6.4%; p < 0.0001). Conclusion Although long-term clinical studies are needed, these results provide insight into which patients might benefit most from this surgery. These results also suggest that surgical ND can produce an acute improvement in nerve function for both men and women, for people with type 1 and 2 diabetes, and across a wide range of ages, BMI, A1c levels, and disease duration.

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Chronic Nerve Compression Accelerates the Progression of Diabetic Peripheral Neuropathy in a Rat Model: A Study of Gene Expression Profiling

Cited by 2 publications

References 29 publications

A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats

A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats

Acute Improvement in Intraoperative EMG During Common Fibular Nerve Decompression in Patients with Symptomatic Diabetic Sensorimotor Peripheral Neuropathy: EMG and Clinical Attribute Interrelations

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