Chronic myeloid leukemia in a  pediatric population in the Congo

Ngolet, Lydie Ocini; Ova, Jenny Guelongo Okouango; Dokékias, Alexis Elira

doi:10.17546/msd.299108

Cited by 4 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The two cases seen in our centre were aged 10 years and above. This is similar to previous reports by Ngolet et al [14] in Congo where all and Lalit Rau et al [15] in India where majority (77%) of the CML patients were in the age range of 10-17 years. This supports the fact that CML is a disease more prevalent in adolescence.…”

Section: Discussionsupporting

confidence: 92%

“…This contrasts with the response from case 2, in whom initial HU (from OAUTH Ile-Ife) therapy resulted in reduction in total WBC from above 500 × 10 9 /L to 7.4 × 10 9 /L and also as noted by previous researchers [7,15]. However, commencement of imatinib therapy did not yield good response in this patient, similar to earlier reports by Ngolet et al [14] but differed from reports of Oyekunle et al [4], who reported that 93% of his study population achieved complete haematological response after 90-day therapy on imatinib, while two out of the 14 cases had complete cytogenetic remission. This poor response of our patient could be attributed to the poor prognostic factors seen in our patient, which included older age, massive splenomegaly, hepatomegaly, late presentation and Philadelphia chromosome positivity.…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Paediatric Chronic Myeloid Leukaemia in a Tertiary Hospital in Nigeria: A Report of Two Cases

Patricia¹,

Ukamaka²,

Clifford³

et al. 2019

JPP

View full text Add to dashboard Cite

Background: Chronic myeloid leukaemia (CML) is a myeloproliferative disorder with BCR/ABL mutation characterized by proliferation of granulocytic cell lines at varying stages of development. It is predominantly a disease of the adult population, only accounting for 2-3% of all childhood leukaemia. In our tertiary hospital, we recorded two cases of paediatric CML within three years. Objective: To increase the awareness of physicians on this seemingly rare form of childhood leukaemia. Case reports: We report a 10 year-old boy and a 16 year-old girl who presented to our facility with features suggestive of CML. Both cases had splenomegaly and leucocytosis. Cytogenetic assessment was positive for BCR-ABL in both cases. The first case was in chronic phase (CP) and had an initial therapy of hydroxyurea (HU) before referral for imatinib therapy. The second case received imatinib therapy, however due to blastic transformation to acute myeloid leukaemia (AML), she received treatment comprising of intravenous anthracycline and cytarabine. Conclusion: CML, although one of the rare childhood leukaemia is becoming increasingly noticed, probably due to availability of diagnostic facilities. There is therefore need for increased awareness of the disease among physicians to minimize delays in the diagnosis for improved care and better outcome.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 81%

Paediatric Chronic Myeloid Leukaemia in a Tertiary Hospital in Nigeria: A Report of Two Cases

Patricia¹,

Ukamaka²,

Clifford³

et al. 2019

JPP

View full text Add to dashboard Cite

show abstract

“…Women predominated at 61.7%, with a sex ratio of 0.6. This female predominance was also observed by other authors in Africa who carried out studies among adult SCD patients [ 13 , 17 ]. Less than a quarter of patients (11%) had no professional activity.…”

Section: Discussionsupporting

confidence: 83%

Homozygous Sickle Cell Disease after Age of 40: Follow‐Up of a Cohort of 209 Patients in Senegal, West Africa

Seck,

Dabo,

Bousso

et al. 2024

Advances in Hematology

View full text Add to dashboard Cite

Objectives. The aim of this study was to describe the morbidity and mortality of homozygous sickle cell disease after the age of 40. Methods. This was a cohort study of 209 patients followed from 1994 to 2022. All hemoglobin electrophoresis-confirmed SS sickle cell patients over 40 years were included. A descriptive study of epidemiological, diagnostic, therapeutic, and evolutionary data was used to assess morbidity and mortality. Results. Sex ratio (M/F) was 0.6. Median age was 47 (41–75). According to morbidity, 95.1% had less than 3 vaso-occlusive crises/year. Acute anemia was the most frequent complication (52.63%). Chronic complications were noted in 32.5%. At diagnosis, mean hemoglobin was 8.1 g/dl ± 1.9, HbS was 86.5 ± 10, and HbF was 9.4 ± 7.6. Number of patients transfused was 66%. We noted that 8.1% of patients died, 29.2% were lost to follow-up, and 62.7% were still being followed up. The risk factors identified for death were geographical origin, comorbidity, high HbS, low HbF, and thrombocytosis. Conclusion. This study shows that homozygous SCD is increasingly becoming an adult disease and that it can be carried into old age in Africa. Advanced age over 40 is marked by an upsurge in chronic complications, making it essential to set up a screening program and to organize multidisciplinary follow-up.

show abstract

“…This result is similar to that reported by Ngolet et al where gallbladder lithiasis represented 40.3%. [22] Adolescents with sickle cell disease have normal pubertal development (56.5%). Mandese et al in Italy, report a prevalence of 50% [5].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Pubertal Delay in Adolescents with Homozygous Sickle Cell Disease and Socio-Demographic, Clinical Factors

Mbamognoua,

Edzan,

Mawa

et al. 2023

OJEMD

View full text Add to dashboard Cite

Introduction: Pubertal development is a process leading to the acquisition of reproductive capacities. Among the factors that inhibit pubertal development are chronic diseases including sickle cell anemia, which is a public health problem. Objectives: Describe the sociodemographic and clinical characteristics of adolescents with sickle cell disease. Report the prevalence of abnormalities of pubertal development. Identify associated factors that delay pubertal development. Patients and Methods: This was a multicenter analytical cross-sectional study over 7 months at the National Reference Center for Sickle Cell Disease and, at the Brazzaville University Hospital. It concerned adolescents with sickle cell disease aged between 10 to 19 years. The study focused on the sociodemographic characteristics of adolescents, the natural history of sickle cell anemia and the evaluation of secondary sexual characteristics using the Tanner classification. Nutritional status was assessed by calculating body mass index (BMI) and height/age and weight/age ratios. Results: Of the 347 adolescents included, the average age of the adolescents was 15.1 ± 2.5 years, 56.5% had normal puberty, 42.6% had delayed puberty and 0.9% had impuberty. The associated factors were under-nutrition with less than 3 meals/day (p = 0.0000), social status with more marked pubertal delay in orphans (p = 0.00127), more than 5 hospitalizations per year (p = 0.0013), pubertal delay was statistically significant in adolescents who had more than 3 vaso-occlusive crises (p = 0.0000), and those who had more than 5 blood How to cite this paper: Mbamognoua,

show abstract

Chronic myeloid leukemia in a pediatric population in the Congo

Cited by 4 publications

References 6 publications

Paediatric Chronic Myeloid Leukaemia in a Tertiary Hospital in Nigeria: A Report of Two Cases

Paediatric Chronic Myeloid Leukaemia in a Tertiary Hospital in Nigeria: A Report of Two Cases

Homozygous Sickle Cell Disease after Age of 40: Follow‐Up of a Cohort of 209 Patients in Senegal, West Africa

Correlation between Pubertal Delay in Adolescents with Homozygous Sickle Cell Disease and Socio-Demographic, Clinical Factors

Contact Info

Product

Resources

About