Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma

Alsop, Skylar; Sanger, Warren G.; Elenitoba-Johnson, Kojo S.J.; Lim, Megan S.

doi:10.1016/j.humpath.2007.05.018

Cited by 14 publications

(11 citation statements)

References 7 publications

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“…Three retrospective studies and several individual case reports reviewed cases of secondary CML in a variety of diseases including untreated malignancies, immunosuppression therapies and solid organ transplants without underlying malignancy [3,4,[10][11][12][13]. None of the studies could render an association between chemotherapy and secondary CML.…”

Section: Discussionmentioning

confidence: 99%

Pediatric secondary chronic myeloid leukemia following cardiac transplantation for anthracycline‐induced cardiomyopathy

Menon

Katsanis

Khalpey

et al. 2014

Pediatric Blood & Cancer

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Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cell that is exceptionally rare in the first five years of life, particularly as a secondary malignancy. This report describes a case of secondary CML in a four-year-old female occurring after AML treatment. Interestingly, CML developed while on immunosuppression for a heart transplant due to anthracycline-induced cardiomyopathy.

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Section: Discussionmentioning

confidence: 99%

Pediatric secondary chronic myeloid leukemia following cardiac transplantation for anthracycline‐induced cardiomyopathy

Menon

Katsanis

Khalpey

et al. 2014

Pediatric Blood & Cancer

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“…Theauthorssuggestedthatthetimeintervalforexpansion of the malignant clone was at least 16 months [14]. Our patient developed CML relatively shortly after treatment of DLBCLwithlatencytimeofonly9monthsbetweenthe2dis-eases, suggesting the hypothesis of non-treatment related CML (nTr-CML) occurring as well as a primary de novo disorder.Indeed,nTr-CMLasasecondmalignancyisarare entity [15,16]. 9 case reports of nTr-CML occurring in patients with previous neoplasms, who had not been treated with chemotherapy, are summarized in table 2.…”

Section: Discussionmentioning

confidence: 99%

Chronic Myeloid Leukemia as a Secondary Malignancy after Lymphoma in a Child. A Case Report and Review of the Literature

Zahra

Fredj²,

Youssef³

et al. 2012

Onkologie

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Background: Philadelphia chromosome-positive chronic myeloid leukemia (CML) in children is very rare. CML occurring as a secondary malignancy in individuals treated for diffuse large B-cell lymphoma (DLBCL) is also rare. Case Report: We present the case of a 5-year-old female patient who developed a right orbital mass that was diagnosed as DLBCL. 9 months after receiving treatment for DLBCL, she presented with a white cell count of 250,000/mm³. Peripheral blood and bone marrow (BM) evaluation revealed a myeloproliferative disorder. Cytogenetic and molecular studies demonstrated the presence of t(9;22). CML following DLBCL has not been previously described in the younger population. To our knowledge, this is the first report of a child who developed a CML as a second malignancy after DLBCL. Therapy-related CML and non-therapy-related secondary CML are discussed as potential explanations of this highly unusual clinical presentation. Conclusion: Hematological disorders such as CML may occur after lymphomas. With the increased use of BM cytogenetic studies during staging for lymphoid malignancies, future studies may be able to clarify the question of whether the CML clone in some of these patients existed before treatment for lymphoma.

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“…Philadelphia (Ph) chromosome (t(9; 22)(q34; q11))-positive chronic myeloid leukemia (CML) occurring as a secondary malignancy in patients who were treated for non-Hodgkin lymphoma (NHL) is very rare [1,2]. The association between B-cell–derived lymphoid neoplasias and myeloproliferative disorders is not clear [1].…”

Section: To the Editormentioning

confidence: 99%

“…The association between B-cell–derived lymphoid neoplasias and myeloproliferative disorders is not clear [1]. Until now, CML has been reported after treatment for Hodgkin disease (HD), hairy cell leukemia, or chronic lymphocytic leukemia (CLL).…”

Section: To the Editormentioning

confidence: 99%

Chronic Myeloid Leukemia as a Secondary Malignancy Following Treatment of Diffuse Large B-Cell Lymphoma

Demiriz¹,

Tekgündüz²,

Bozdağ³

et al. 2014

Tjh

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Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma

Cited by 14 publications

References 7 publications

Pediatric secondary chronic myeloid leukemia following cardiac transplantation for anthracycline‐induced cardiomyopathy

Pediatric secondary chronic myeloid leukemia following cardiac transplantation for anthracycline‐induced cardiomyopathy

Chronic Myeloid Leukemia as a Secondary Malignancy after Lymphoma in a Child. A Case Report and Review of the Literature

Chronic Myeloid Leukemia as a Secondary Malignancy Following Treatment of Diffuse Large B-Cell Lymphoma

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