1924
DOI: 10.1001/jama.1924.02650450001001
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Chronic Myelogenous Leukemia

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Cited by 168 publications
(9 citation statements)
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“…In no instance did the haemoglobin level fall more than 1 to 1'5 g/100 ml when hydroxyurea was stopped, which is compatible with a satisfactory clinical state. The cumulative duration of survival of patients submitted to the hydroxyurea-leucopheresis protocol was no different from the survival times of patients treated conventionally with busulphan (Haut et al, 1961;Medical Research Council, 1968) and mitobronitol (Co-operative Study Group, 1972), which were only slightly longer than those obtained by irradiation of the spleen (Medical Research Council, 1968) and therapy with "P (Reinhard et al, 1959), the latter survival time being no different from ithat of untreated patients (Minot et al, 1924).…”
Section: Leucopheresis In Hydroxyurea-treated Patientsmentioning
confidence: 89%
“…In no instance did the haemoglobin level fall more than 1 to 1'5 g/100 ml when hydroxyurea was stopped, which is compatible with a satisfactory clinical state. The cumulative duration of survival of patients submitted to the hydroxyurea-leucopheresis protocol was no different from the survival times of patients treated conventionally with busulphan (Haut et al, 1961;Medical Research Council, 1968) and mitobronitol (Co-operative Study Group, 1972), which were only slightly longer than those obtained by irradiation of the spleen (Medical Research Council, 1968) and therapy with "P (Reinhard et al, 1959), the latter survival time being no different from ithat of untreated patients (Minot et al, 1924).…”
Section: Leucopheresis In Hydroxyurea-treated Patientsmentioning
confidence: 89%
“…20 In 1998, a population-based survey in Norway also described a median survival of 36 months, with an estimated 5-year survival rate of 33%.…”
Section: Survivalmentioning
confidence: 99%
“…The only series of untreated patients for which survival data are available is that of Minot, Buckman, and Isaacs (1924). The survival of 52 untreated patients was compared with that of 78 patients treated by irradiation, chiefly from radium.…”
Section: Comparison With Other Seriesmentioning
confidence: 99%