Chronic Myelogenous Leukemia That Occurred Two Years after the Diagnosis of Adult Still's Disease

Nakagawa, Yoshifumi; Furusyo, Norihiro; Taniai, Hiroaki; Henzan, Hideho; Tsuchihashi, Takuya; Hayashi, Jun

doi:10.2169/internalmedicine.44.994

Cited by 10 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…specimens are nondiagnostic of lymphoma at the time of initial presentation 40,43 to account for a paraneoplastic presentation and a diagnosis of AOSD is rendered. 26,31,40,43 To a lesser degree, leukemias and myelodysplastic syndrome have also been linked to AOSD-like presentations, 23,24,35,36,53 some not presenting until 6 years after the initial diagnosis of AOSD despite a normocellular marrow biopsy specimen at the time of initial presentation. 23 The second strongest association for AOSD-like symptomatology is with breast cancer (6/31; 19%).…”

Section: Anamentioning

confidence: 99%

“…Management of the symptoms of AOSD symptoms in the setting of malignancy required high-dose systemic glucocorticoids in 26 cases [23][24][25][26][27][28][29][30][31][32][33][34][35][38][39][40][41][42][43][44][45]47,[50][51][52] and additional systemic therapies in 6 cases, including cyclosporine, 23,35,41 methotrexate, 24,31 cyclophosphamide, 31,35 and azathioprine. 32 Importantly, multiple reports have reflected the relapse of symptoms while weaning off antiinflammatory therapy in the absence of definitive treatment of the primary malignancy.…”

Section: Anamentioning

confidence: 99%

See 1 more Smart Citation

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Sun

Brezinski

Berliner

et al. 2015

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Anamentioning

confidence: 99%

Section: Anamentioning

confidence: 99%

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Sun

Brezinski

Berliner

et al. 2015

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…About 10 to 20% of MDS/CMML could be associated with various extra hematological features, e.g., neutrophilic dermatoses, systemic vasculitis, inflammatory arthritis, pseudo-Behçet’s disease, and relapsing polychondritis [ 5 , 6 , 7 , 8 ]. For years now, the state of autoinflammatory disorders associated with neoplasia reported in the literature were mainly associated with solid cancer but also MDS/CMML, myeloproliferative disorders, and lymphoma, and identified in the literature as “paraneoplastic AOSD” or “malignant associated AOSD” [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

USAID Associated with Myeloid Neoplasm and VEXAS Syndrome: Two Differential Diagnoses of Suspected Adult Onset Still’s Disease in Elderly Patients

Delplanque

Aouba

Hirsch

et al. 2021

JCM

View full text Add to dashboard Cite

Background: Patients with solid cancers and hematopoietic malignancy can experience systemic symptoms compatible with adult-onset Still’s disease (AOSD). The newly described VEXAS, associated with somatic UBA1 mutations, exhibits an overlap of clinical and/or biological pictures with auto inflammatory signs and myelodysplastic syndrome (MDS). Objectives: To describe a cohort of patients with signs of undifferentiated systemic autoinflammatory disorder (USAID) concordant with AOSD and MDS/chronic myelomonocytic leukemia (CMML) and the prevalence of VEXAS proposed management and outcome. Methods: A French multicenter retrospective study from the MINHEMON study group also used for other published works with the support of multidisciplinary and complementary networks of physicians and a control group of 104 MDS/CMML. Results: Twenty-six patients were included with a median age at first signs of USAID of 70.5 years with male predominance (4:1). Five patients met the criteria for confirmed AOSD. The most frequent subtypes were MDS with a blast excess (31%) and MDS with multilineage dysplasia (18%). Seven patients presented with acute myeloid leukemia and twelve died during a median follow-up of 2.5 years. Six out of 18 tested patients displayed a somatic UBA1 mutation concordant with VEXAS, including one woman. High-dose corticosteroids led to a response in 13/16 cases and targeted biological therapy alone or in association in 10/12 patients (anakinra, tocilizumab, and infliximab). Azacytidine resulted in complete or partial response in systemic symptoms for 10/12 (83%) patients including 3 VEXAS. Conclusion: Systemic form of VEXAS syndrome can mimic AOSD. The suspicion of USAID or AOSD in older males with atypia should prompt an evaluation of underlying MDS and assessment of somatic UBA1 mutation.

show abstract

“…Therefore, to exclude hematological malignancies, the researchers suggest bone marrow aspiration and lymph node biopsy ( 93 ). In addition, a case reported that a patient was diagnosed with chronic myeloid leukemia two years after being diagnosed with AOSD, which also suggests the possibility of the development of complications ( 94 ). The prognosis of AOSD mainly depends on the severity of visceral involvement and the degree of joint erosion ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

Bibliometrics analysis on the research status and trends of adult-onset Still’s disease: 1921-2021

et al. 2022

View full text Add to dashboard Cite

ObjectivesThe aim of this research is to discuss the research status, hotspots, frontiers and development trends in the field of adult-onset Still’s disease (AOSD) based on bibliometrics and visual analysis by CiteSpace software.MethodsThe relevant research articles on AOSD from 1921 to 2021 were retrieved from the Scopus database. CiteSpace software was used to form a visual knowledge map and conduct analysis for the countries/regions, journals, authors, keywords, clusters, research hotspots and frontiers of the included articles.ResultsThere were 2,373 articles included, and the number of articles published during 1921-2021 is increasing. The country with the highest number of articles published was Japan (355, 14.96%), followed by the United States (329, 13.86%) and France (215, 9.06%). The author with the highest number of publications is Ansell, Barbara M. (30, 1.26%), and the author with the highest co-citation frequency is Yamaguchi, Masaya (703). Clinical Rheumatology is the journal with the highest publication frequency. The top five cluster groups were “joint”, “differential diagnosis”, “prednisolone”, “methotrexate” and “macrophage activation syndrome”. The diagnosis, treatment and pathogenesis of AOSD form the main research fields, and prognosis and complications are the research hotspots and trends.ConclusionsThe global research field in AOSD has expanded in the past 100 years. The complications and new pathogenesis of AOSD are hotspots in this field and need further study in the future.

show abstract

Chronic Myelogenous Leukemia That Occurred Two Years after the Diagnosis of Adult Still's Disease

Cited by 10 publications

References 8 publications

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

USAID Associated with Myeloid Neoplasm and VEXAS Syndrome: Two Differential Diagnoses of Suspected Adult Onset Still’s Disease in Elderly Patients

Bibliometrics analysis on the research status and trends of adult-onset Still’s disease: 1921-2021

Contact Info

Product

Resources

About