Chronic muscle stimulation improves ischaemic muscle performance in patients with peripheral vascular disease

Tsang, Gmk; Ma, Genshan; Crow, A.; Smith, Frank C T; Beck, Sandra J.; Hudlická, O; Shearman, CP

doi:10.1016/s0950-821x(05)80960-0

Cited by 38 publications

(50 citation statements)

References 3 publications

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“…Unfortunately, chronic ischemia leads to vasodilatory dysfunction. Ischemic arterioles in the lower leg have impaired functional vasodilation, which could be explained by impaired endothelial-dependent dilation [69,70]. Similar results were found in rat collateral arteries in vitro [71].…”

Section: Aim 2: Future Recommended Modificationssupporting

confidence: 58%

Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery

Struthers¹

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Section: Aim 2: Future Recommended Modificationssupporting

confidence: 58%

Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery

Struthers¹

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“…Clinical trials in humans have shown that TCEMS improves muscle strength and performance in patients with chronic heart failure [9], promotes muscle growth in paraplegic patients [10] and improves the performance of ishaemic muscles in patients with peripheral vascular disease [11]. TCEMS is also an accepted and well-established intervention for COPD patients and is one of the key con- stituents of rehabilitation programme and improves leg muscle strength in patients with advanced COPD [12].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of transcutaneous electrical muscle stimulation in acute exacerbation of COPD

Meglic

Sorli

Košnik

et al. 2011

Wien Klin Wochenschr

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Transcutaneous electrical muscle stimulation is a well-established intervention for rehabilitation of clinically stable patients with chronic obstructive pulmonary disease. This study investigated feasibility and safety of this method during acute exacerbation of chronic obstructive pulmonary disease. We included 19 patients (71 ± 6 years, 76% men) who underwent two sessions/day during hospitalization (15 ± 1 training sessions). They reported good tolerability and excellent safety profile of transcutaneous electrical muscle stimulation. Our results set the stage for future research to determine specific benefit of transcutaneous electrical muscle stimulation, either alone or in combination with nutritional support and pharmacological therapy.

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“…When patients with intermittent claudication, limited to pain-free and maximum walking distance of about 50 and 100 m, respectively, stimulated their calf muscles for 20 min 3 times each day for 4 weeks, their pain-free walking increased by 82% and their maximum walking by 44% [75]. Their calf muscle fatigue during isometric contraction, very much reduced by ischaemia, became similar to age-matched controls [75, 76]. The microvascular benefits of stimulation were evident as a 44% increase in calf blood flow and a significant increase in capillary filtration coefficient [77].…”

Section: Application Of Stimulation Treatment In Peripheral Arterial mentioning

confidence: 99%

Adaptation of Skeletal Muscle Microvasculature to Increased or Decreased Blood Flow: Role of Shear Stress, Nitric Oxide and Vascular Endothelial Growth Factor

Hudlická¹,

Brown

2009

J Vasc Res

119

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This review elucidates the roles of capillary haemodynamics, nitric oxide (NO) and vascular endothelial growth factor (VEGF) in the remodelling of skeletal muscle microcirculation in response to increased (electrical stimulation) or decreased (chronic ischaemia) blood flow. During early stages of stimulation-induced angiogenesis, up-regulation of VEGF and its receptor VEGF receptor 2 is dependent on shear stress and NO release, whereas later, involvement of NO in the expanding capillary bed appears to be VEGF/VEGF receptor 2 independent. Arteriolar growth most likely relies on mechanical wall stresses while growth factor involvement is less clear. By contrast, in muscles with restricted blood flow, increased VEGF/VEGF receptor 2 expression after ischaemia onset is not associated with changes in shear stress or hypoxia, or capillary growth. After several weeks, VEGF protein levels are lower than normal while modest angiogenesis takes place, a temporal mismatch that limits the utility of using growth factor levels during ischaemia to assess angiogenic potential. Chronic stimulation of ischaemic muscles restores their depressed endothelial-dependent arteriolar dilatation, increases capillary shear stress and VEGF receptor 2 and promotes capillary growth. In patients with peripheral vascular disease, electrical stimulation of ischaemic calf muscles increases blood flow, capillary surface area and muscle performance, offering an alternative ‘endogenous’ treatment to gene or cell therapy.

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Chronic muscle stimulation improves ischaemic muscle performance in patients with peripheral vascular disease

Cited by 38 publications

References 3 publications

Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery

Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery

Feasibility of transcutaneous electrical muscle stimulation in acute exacerbation of COPD

Adaptation of Skeletal Muscle Microvasculature to Increased or Decreased Blood Flow: Role of Shear Stress, Nitric Oxide and Vascular Endothelial Growth Factor

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