Chronic mucocutaneous herpes simplex virus and varicella zoster virus infections

Wauters, Odile; Lebas, Eve; Nikkels, Arjen F.

doi:10.1016/j.jaad.2010.07.011

Cited by 52 publications

(49 citation statements)

References 110 publications

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“…Existe reactivación subclínica de VHS en pacientes con infección por VIH; menos de 10% de las reactivaciones presentan síntomas [4]. Se refiere que la infección aguda y las recurrencias por VHS, principalmente el tipo 2, pueden estimular la replicación del VIH [5,6], y se asocian a un aumento de dos a cuatro veces del riesgo de transmisión del VIH.…”

Section: Discussionunclassified

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Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Domínguez¹,

Jara²,

Barboza³

et al. 2017

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Genital herpes is the most common cause of ulcers in sexually transmitted diseases (STDs). It is presented as a single or multiple, painful injury, accompanied by bilateral, also painful, lymphadenopathy. In immunocompromised patients, such as those affected by HIV, Herpes Simplex Virus (HSV) infections have a variety of clinical manifestations; they may be located, scattered or atypical. In addition, lesions may be more extensive and persistent than HIV-negative patients. We present two cases of immunocompromised patients with perianal herpetic ulcers, one HIV carrier, and the other with leukopenia caused by visceral Leishmaniasis.

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Section: Discussionunclassified

“…El cultivo del virus sigue siendo una herramienta esencial para las pruebas de sensibilidad a los medicamentos antivirales. Las alternativas terapéuticas incluyen antivirales no TK-dependientes, tales como el Foscarnet o Cidofovir, que se dirigen directamente a la polimerasa del ADN viral [4].…”

Section: Discussionunclassified

Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Domínguez¹,

Jara²,

Barboza³

et al. 2017

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“…In our patient the presentation was a persistent mucocutaneous wart-like and ulcerative infection, which is one of the commonest atypical presentation of chronic herpes simplex virus infetion associated with HIV. It may occasionally present with other types of immunosuppression as well [3]. Low CD4+ counts also act as a marker of HIV disease progression [10].…”

Section: Discussionmentioning

confidence: 99%

“…On further histopathological work up, Immunohistochemistry for Herpes Simplex virus type 1/2 was positive with reactivity in the nuclei of enlarged and multinucleated keratinocytes. Also a repeat serology for HIV was sent which to our surprise was positive with CD4 count of 39cells/mm 3 . She was then started on Acyclovir 200mg five times a day with improvement after first week of therapy (Fig.…”

Section: Case Reportmentioning

confidence: 99%

Chronic ulcerating genital herpes simplex virus infection: A diagnosis mislead by HIV infection

Parajuli¹,

Acharya²,

Rathi³

et al. 2014

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We report a case of chronic herpes simplex in a 27 year old lady presenting with a history of persistent verrucous ulcer in the natal cleft of nine months duration. The patient was diagnosed and treated initially as a case of Tuberculosis Verrucosa Cutis (TVC) based on the chronicity of the ulcer, negative HIV serological tests and histopathological findings. The diagnosis had to be revised as the lesion was increasing in size and the patient was not responding to treatment even after completing antituberculous treatment for six months. Repeat histopathological examination and immunohistochemistry showed DNA of herpes simplex. Based on this finding a repeat HIV serology was sent which was positive. The ulcer healed after a course of acyclovir. The case is being reported to highlight the importance of considering chronic herpes simplex infection in a case of chronic genital ulcer. In addition this case reminds us the nature of HIV infection to mislead the diagnosis by altering the natural course of the disease process.

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“…Acyclovir-resistant wild-type VZV has been reported among immunocompromised persons, primarily HIVinfected. [26][27][28][29] Vaccine-strain VZV has been shown to have similar susceptibility to antivirals as wild-type virus. 30 Acyclovir-resistant vaccine-strain VZV has been reported in 2 cases among children who were both diagnosed with neuroblastoma and received chemotherapy within 1 week after varicella vaccination.…”

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confidence: 99%