Chronic mucocutaneous candidiasis and congenital susceptibility to Candida

Glocker, Erik; Grimbacher, Bodo

doi:10.1097/aci.0b013e32833fd74f

Cited by 58 publications

(42 citation statements)

References 106 publications

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“…For example, HIV/AIDS patients with low CD4 counts are exquisitely susceptible to OPC but do not experience systemic candidiasis (1,42). Rather, the source of C. albicans in invasive infections is thought to be the GI tract, as two important risk factors for invasive candidiasis are exposure to broad-spectrum antibiotics and GI tract surgery (2).…”

Section: Discussionmentioning

confidence: 99%

The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections

et al. 2014

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d Oropharyngeal candidiasis (OPC [thrush]) is an opportunistic infection caused by the commensal fungus Candida albicans.OPC is common in individuals with HIV/AIDS, infants, patients on chemotherapy, and individuals with congenital immune defects. Immunity to OPC is strongly dependent on the interleukin-23 (IL-23)/IL-17R axis, as mice and humans with defects in IL-17R signaling (IL17F, ACT1, IL-17RA) or in genes that direct Th17 differentiation (STAT3, STAT1, CARD9) are prone to mucocutaneous candidiasis. Conventional Th17 cells are induced in response to C. albicans infection via signals from C-type lectin receptors, which signal through the adaptor CARD9, leading to production of Th17-inducing cytokines such as IL-6, IL-1␤, and IL-23. Recent data indicate that IL-17 can also be made by numerous innate cell subsets. These innate "type 17" cells resemble conventional Th17 cells, but they can be activated without need for prior antigen exposure. Because C. albicans is not a commensal organism in rodents and mice are thus naive to this fungus, we had the opportunity to assess the role of CARD9 in innate versus adaptive responses using an OPC infection model. As expected, CARD9؊/؊ mice failed to mount an adaptive Th17 response following oral Candida infection. Surprisingly, however, CARD9 ؊/؊ mice had preserved innate IL-17-dependent responses to Candida and were almost fully resistant to OPC. Thus, CARD9 is important primarily for adaptive immunity to C. albicans, whereas alternate recognition systems appear to be needed for effective innate responses.

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Section: Discussionmentioning

confidence: 99%

The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections

et al. 2014

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“…Individuals with HIV/ AIDS are particularly prone to this disease, and OPC is considered an AIDS-defining illness (1,2). In addition, OPC is common in patients taking immunodepleting chemotherapy, infants and the elderly, and patients with congenital immunodeficiencies, such as hyper-IgE syndrome (HIES) (3).…”

Section: O Ropharyngeal Candidiasis (Opc; Thrush) Is An Opportunisticmentioning

confidence: 99%

Interleukin-17-Induced Protein Lipocalin 2 Is Dispensable for Immunity to Oral Candidiasis

et al. 2014

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“…Die Messung der Sauerstoffburstreaktion in neutrophilen Granulozyten zeigte eine fehlende Bildung reaktiver Sauerstoffmetaboliten, so dass die Diagnose einer septischen Granulomatose ("chronic granulomatous disease", CGD) gestellt werden konnte. [5,9,12,23].…”

Section: Fall 2 (Fortsetzung)unclassified

Diagnostik primärer Immundefekte

Bernuth

Schwarz

Renner

et al. 2011

Monatsschr Kinderheilkd

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Leitthema Der Beitrag von Baumann u. Niehues[2] vermittelt, wann ein angeborener Immundefekt wahrscheinlich ist. Im vorliegenden Beitrag wird ein abgestuftes Vorgehen zur Diagnostik bei Verdacht auf Immundefekt vorgestellt: Die Basisdiagnostik mit Differenzialblutbild und Immunglobulinspiegeln soll die meisten lebensbedrohlichen und häufige immunologische Erkrankungen erkennen. Erweiterte Diagnostik richtet sich am Infektionsspektrum, an Zeichen einer gestörten Immunregulation, an syndromalen Manifestationen und den Ergebnissen der Basisdiagnostik aus. Sie schließt Lücken derselben und grenzt die molekulare Ursache des Immundefekts auf einen Teilbereich des Immunsystems ein. Die exakte Beschreibung des klinischen und immunologischen Phänotyps ist Voraussetzung für eine gezielte und ökonomische molekulargenetische Dia gnostik.

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Chronic mucocutaneous candidiasis and congenital susceptibility to Candida

Cited by 58 publications

References 106 publications

The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections

The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections

Interleukin-17-Induced Protein Lipocalin 2 Is Dispensable for Immunity to Oral Candidiasis

Diagnostik primärer Immundefekte

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