Chronic Mucocutaneous Candidiasis

Filler, Scott G.; EdwardsJr., John E.

doi:10.1007/978-1-4899-2400-1_5

Cited by 5 publications

(3 citation statements)

References 69 publications

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“…The most common deficiency appears to be one of cell-mediated immune responses against candida antigens, as discussed below, although abnormalities in chemotaxis or phagocytic cell function have also been reported (176,222,235,276,282). Other host defense mechanisms, such as humoral immunity and the complement system, have generally been found to be normal in these patients (76,144,145,147,275).…”

Section: Cutaneous Candidiasismentioning

confidence: 98%

“…In human patients with chronic mucocutaneous candidiasis the most common immunologic abnormalities found are defects in cell-mediated immunity (76,117,145,147,275). These defects fall into three general groups: (i) anergy to all antigens tested, (ii) unresponsiveness to candida antigens only, and (c) normal responses to all antigens, including those from candida.…”

Section: Cutaneous Candidiasismentioning

confidence: 99%

“…A variety of treatments aimed at restoring immune function have been tried in patients with chronic mucocutaneous candidiasis (76,147); these treatments have involved thymic transplantation, thymic hormone replacement, infusion of leukocytes from normal donors, bone marrow transplantation, and administration of transfer factor from candida skin test-positive donors. Of these various therapies, the combination of transfer factor administration with specific antifungal therapy probably has given the best results (147).…”

Section: Cutaneous Candidiasismentioning

confidence: 99%

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Cutaneous defenses against dermatophytes and yeasts

1995

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Predispositions to the superficial mycoses include warmth and moisture, natural or iatrogenic immunosuppression, and perhaps some degree of inherited susceptibility. Some of these infections elicit a greater inflammatory response than others, and the noninflammatory ones are generally more chronic. The immune system is involved in the defense against these infections, and cell-mediated immunity appears to be particularly important. The mechanisms involved in generating immunologic reactions in the skin are complex, with epidermal Langerhans cells, other dendritic cells, lymphocytes, microvascular endothelial cells, and the keratinocytes themselves all participating in one way or another. A variety of defects in the immunologic response to the superficial mycoses have been described. In some cases the defect may be preexistent, whereas in others the infection itself may interfere with protective cell-mediated immune responses against the organisms. A number of different mechanisms may underlie these immunologic defects and lead to the development of chronic superficial fungal infection in individual patients. Although the immunologic defects appear to be involved in the chronicity of certain types of cutaneous fungal infections, treatment of these defects remains experimental at the present time.

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